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There are 386 publications that match the search string
programme => Early Life Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders
Population-Based Study of Rare Coding Variants in /SF-1.
Kouri C, Jia RY, Kentistou KA, Gardner EJ, Perry JRB, Flück CE, Ong KK
Journal of the Endocrine Society Oct 2024
(DOI : 10.1210/jendso/bvae178)
Jia RY, Lockhart S, Lam BYH, Zhao Y, Kentistou KA, Gardner EJ, Farooqi IS, O'Rahilly S, Day FR, Ong KK, Perry JRB, Ong K, Perry JR, Kentistou K
The Journal of clinical endocrinology and metabolism Oct 2024
(DOI : 10.1210/clinem/dgaf132)
QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction.
Maharaj AV, Ishida M, Rybak A, Elfeky R, Andrews A, Joshi A, Elmslie F, Joensuu A, Kantojärvi K, Jia RY, Perry JRB, O'Toole EA, McGuffin LJ, Hwa V, Storr HL
Nature communications Sep 2024
(DOI : 10.1038/s41467-024-52587-w)
Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S
Nature metabolism Sep 2024
(DOI : 10.1038/s42255-024-01126-4)
Chundru VK, Zhang Z, Walter K, Lindsay SJ, Danecek P, Eberhardt RY, Gardner EJ, Malawsky DS, Wigdor EM, Torene R, Retterer K, Wright CF, Ólafsdóttir H, Guillen Sacoto MJ, Ayaz A, Akbeyaz IH, Türkdoğan D, Al Balushi AI, Bertoli-Avella A, Bauer P, Szenker-Ravi E, Reversade B, McWalter K, Sheridan E, Firth HV, Hurles ME, Samocha KE, Ustach VD, Martin HC
Nature genetics Sep 2024
(DOI : 10.1038/s41588-024-01910-8)
High-resolution functional mapping of RAD51C by saturation genome editing.
Olvera-León R, Zhang F, Offord V, Zhao Y, Tan HK, Gupta P, Pal T, Robles-Espinoza CD, Arriaga-González FG, Matsuyama LSAS, Delage E, Dicks E, Ezquina S, Rowlands CF, Turnbull C, Pharoah P, Perry JRB, Jasin M, Waters AJ, Adams DJ
Cell Sep 2024
(DOI : 10.1016/j.cell.2024.08.039)
Genetic links between ovarian ageing, cancer risk and de novo mutation rates.
Stankovic S, Shekari S, Huang QQ, Gardner EJ, Ivarsdottir EV, Owens NDL, Mavaddat N, Azad A, Hawkes G, Kentistou KA, Beaumont RN, Day FR, Zhao Y, Jonsson H, Rafnar T, Tragante V, Sveinbjornsson G, Oddsson A, Styrkarsdottir U, Gudmundsson J, Stacey SN, Gudbjartsson DF, Breast Cancer Association Consortium Breast Cancer Association Consortium, Kennedy K, Wood AR, Weedon MN, Ong KK, Wright CF, Hoffmann ER, Sulem P, Hurles ME, Ruth KS, Martin HC, Stefansson K, Perry JRB, Murray A
Nature Sep 2024
(DOI : 10.1038/s41586-024-07931-x)
Mukhtar TK, Wilcox N, Dennis J, Yang X, Naven M, Mavaddat N, Perry JRB, Gardner E, Easton DF
Journal of medical genetics Aug 2024
(DOI : 10.1136/jmg-2024-110127)
Olwi DI, Kaisinger LR, Kentistou KA, Vaudel M, Stankovic S, Njølstad PR, Johansson S, Perry JRB, Day FR, Ong KK
International journal of obesity (2005) Aug 2024
(DOI : 10.1038/s41366-024-01605-4)
Li C, Bishop TRP, Imamura F, Sharp SJ, Pearce M, Brage S, Ong KK, Ahsan H, Bes-Rastrollo M, Beulens JWJ, den Braver N, Byberg L, Canhada S, Chen Z, Chung HF, Cortes-Valencia A, Djoussé L, Drouin-Chartier JP, Du H, Du S, Duncan BB, Gaziano JM, Gordon-Larsen P, Goto A, Haghighatdoost F, Härkänen T, Hashemian M, Hu FB, Ittermann T, Järvinen R, Kakkoura MG, Neelakantan N, Knekt P, Lajous M, Li Y, Magliano DJ, Malekzadeh R, Le Marchand L, Marques-Vidal P, Martínez-González MÁ, Maskarinec G, Mishra GD, Mohammadifard N, O'Donoghue G, O'Gorman D, Popkin B, Poustchi H, Sarrafzadegan N, Sawada N, Schmidt MI, Shaw JE, Soedamah-Muthu S, Stern D, Tong L, van Dam RM, Völzke H, Willett WC, Wolk A, Yu C, EPIC-InterAct Consortium EPIC-InterAct Consortium, Forouhi NG, Wareham NJ
The lancet. Diabetes & endocrinology Aug 2024
(DOI : 10.1016/S2213-8587(24)00179-7)
Loss of transient receptor potential channel 5 causes obesity and postpartum depression.
Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS
Cell Jul 2024
(DOI : 10.1016/j.cell.2024.06.001)
Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polasek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de González A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernández-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, ABCTB Investigators ABCTB Investigators, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolcic I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widén E, Wilson JF, Lifelines Cohort Study Lifelines Cohort Study, Danish Blood Donor Study Danish Blood Donor Study, Ovarian Cancer Association Consortium Ovarian Cancer Association Consortium, Breast Cancer Association Consortium Breast Cancer Association Consortium, Biobank Japan Project Biobank Japan Project, China Kadoorie Biobank Collaborative Group China Kadoorie Biobank Collaborative Group, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK
Nature genetics Jul 2024
(DOI : 10.1038/s41588-024-01798-4)
Genetic drivers and cellular selection of female mosaic X chromosome loss.
Liu A, Genovese G, Zhao Y, Pirinen M, Zekavat SM, Kentistou KA, Yang Z, Yu K, Vlasschaert C, Liu X, Brown DW, Hudjashov G, Gorman BR, Dennis J, Zhou W, Momozawa Y, Pyarajan S, Tuzov V, Pajuste FD, Aavikko M, Sipilä TP, Ghazal A, Huang WY, Freedman ND, Song L, Gardner EJ, FinnGen FinnGen, Estonian Biobank Research Team Estonian Biobank Research Team, Breast Cancer Association Consortium Breast Cancer Association Consortium, Million Veteran Program Million Veteran Program, Sankaran VG, Palotie A, Ollila HM, Tukiainen T, Chanock SJ, Mägi R, Natarajan P, Daly MJ, Bick A, McCarroll SA, Terao C, Loh PR, Ganna A, Perry JRB, Machiela MJ
Nature Jun 2024
(DOI : 10.1038/s41586-024-07533-7)
Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause.
Yazdanpanah M, Yazdanpanah N, Gamache I, Ong K, Perry JRB, Manousaki D
Genome medicine May 2024
(DOI : 10.1186/s13073-024-01322-7)
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation.
Leeson-Payne A, Iyinikkel J, Malcolm C, Lam BYH, Sommer N, Dowsett GKC, Martinez de Morentin PB, Thompson D, Mackenzie A, Chianese R, Kentistou K, Gardner EJ, Perry JRB, Grassmann F, Speakman JR, Rochford JJ, Yeo GSH, Murray F, Heisler LK
Cell metabolism Apr 2024
(DOI : 10.1016/j.cmet.2024.03.016)
Zhao Y, Chukanova M, Kentistou KA, Fairhurst-Hunter Z, Siegert AM, Jia RY, Dowsett GKC, Gardner EJ, Lawler K, Day FR, Kaisinger LR, Tung YL, Lam BYH, Chen HC, Wang Q, Berumen-Campos J, Kuri-Morales P, Tapia-Conyer R, Alegre-Diaz J, Barroso I, Emberson J, Torres JM, Collins R, Saleheen D, Smith KR, Paul DS, Merkle F, Farooqi IS, Wareham NJ, Petrovski S, O'Rahilly S, Ong KK, Yeo GSH, Perry JRB
Nature genetics Apr 2024
(DOI : 10.1038/s41588-024-01694-x)
Genetic determinants of micronucleus formation in vivo.
Adams DJ, Barlas B, McIntyre RE, Salguero I, van der Weyden L, Barros A, Vicente JR, Karimpour N, Haider A, Ranzani M, Turner G, Thompson NA, Harle V, Olvera-León R, Robles-Espinoza CD, Speak AO, Geisler N, Weninger WJ, Geyer SH, Hewinson J, Karp NA, Sanger Mouse Genetics Project Sanger Mouse Genetics Project, Fu B, Yang F, Kozik Z, Choudhary J, Yu L, van Ruiten MS, Rowland BD, Lelliott CJ, Del Castillo Velasco-Herrera M, Verstraten R, Bruckner L, Henssen AG, Rooimans MA, de Lange J, Mohun TJ, Arends MJ, Kentistou KA, Coelho PA, Zhao Y, Zecchini H, Perry JRB, Jackson SP, Balmus G
Nature Feb 2024
(DOI : 10.1038/s41586-023-07009-0)
Bradfield JP, Kember RL, Ulrich A, Balkiyarova Z, Alyass A, Aris IM, Bell JA, Broadaway KA, Chen Z, Chai JF, Davies NM, Fernandez-Orth D, Bustamante M, Fore R, Ganguli A, Heiskala A, Hottenga JJ, Íñiguez C, Kobes S, Leinonen J, Lowry E, Lyytikäinen LP, Mahajan A, Pitkänen N, Schnurr TM, Have CT, Strachan DP, Thiering E, Vogelezang S, Wade KH, Wang CA, Wong A, Holm LA, Chesi A, Choong C, Cruz M, Elliott P, Franks S, Frithioff-Bøjsøe C, Gauderman WJ, Glessner JT, Gilsanz V, Griesman K, Hanson RL, Kaakinen M, Kalkwarf H, Kelly A, Kindler J, Kähönen M, Lanca C, Lappe J, Lee NR, McCormack S, Mentch FD, Mitchell JA, Mononen N, Niinikoski H, Oken E, Pahkala K, Sim X, Teo YY, Baier LJ, van Beijsterveldt T, Adair LS, Boomsma DI, de Geus E, Guxens M, Eriksson JG, Felix JF, Gilliland FD, Biobank PM, Hansen T, Hardy R, Hivert MF, Holm JC, Jaddoe VWV, Järvelin MR, Lehtimäki T, Mackey DA, Meyre D, Mohlke KL, Mykkänen J, Oberfield S, Pennell CE, Perry JRB, Raitakari O, Rivadeneira F, Saw SM, Sebert S, Shepherd JA, Standl M, Sørensen TIA, Timpson NJ, Torrent M, Willemsen G, Hyppönen E, Power C, Early Growth Genetics Consortium Early Growth Genetics Consortium, McCarthy MI, Freathy RM, Widén E, Hakonarson H, Prokopenko I, Voight BF, Zemel BS, Grant SFA, Cousminer DL
Genome biology Jan 2024
(DOI : 10.1186/s13059-023-03136-z)
Yazdanpanah N, Jumentier B, Yazdanpanah M, Ong KK, Perry JRB, Manousaki D
Communications biology Jan 2024
(DOI : 10.1038/s42003-023-05737-7)
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Fejzo M, Rocha N, Cimino I, Lockhart SM, Petry CJ, Kay RG, Burling K, Barker P, George AL, Yasara N, Premawardhena A, Gong S, Cook E, Rimmington D, Rainbow K, Withers DJ, Cortessis V, Mullin PM, MacGibbon KW, Jin E, Kam A, Campbell A, Polasek O, Tzoneva G, Gribble FM, Yeo GSH, Lam BYH, Saudek V, Hughes IA, Ong KK, Perry JRB, Sutton Cole A, Baumgarten M, Welsh P, Sattar N, Smith GCS, Charnock-Jones DS, Coll AP, Meek CL, Mettananda S, Hayward C, Mancuso N, O'Rahilly S
Nature Dec 2023
(DOI : 10.1038/s41586-023-06921-9)
Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation.
Radford EJ, Tan HK, Andersson MHL, Stephenson JD, Gardner EJ, Ironfield H, Waters AJ, Gitterman D, Lindsay S, Abascal F, Martincorena I, Kolesnik-Taylor A, Ng-Cordell E, Firth HV, Baker K, Perry JRB, Adams DJ, Gerety SS, Hurles ME
Nature communications Dec 2023
(DOI : 10.1038/s41467-023-43041-4)
Mbarek H, Gordon SD, Duffy DL, Hubers N, Mortlock S, Beck JJ, Hottenga JJ, Pool R, Dolan CV, Actkins KV, Gerring ZF, van Dongen J, Ehli EA, Iacono WG, McGue M, Chasman DI, Gallagher CS, Schilit SLP, Morton CC, Pare G, Willemsen G, Whiteman DC, Olsen CM, Derom C, Vlietinck R, Gudbjartsson D, Cannon-Albright L, Krapohl E, Plomin R, Magnusson PKE, Pedersen NL, Hysi P, Mangino M, Spector TD, Palviainen T, Milaneschi Y, Penninnx BW, Campos AI, Ong KK, Perry JRB, Lambalk CB, Kaprio J, Olafsson I, Duroure K, Revenu C, Rentería ME, Yengo L, Davis L, Derks EM, Medland SE, Stefánsson H, Stefansson K, Del Bene F, Reversade B, Montgomery GW, Boomsma DI, Martin NG
Human reproduction (Oxford, England) Dec 2023
(DOI : 10.1093/humrep/dead247)
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra's seminal work.
Anderson GM, Hill JW, Kaiser UB, Navarro VM, Ong KK, Perry JRB, Prevot V, Tena-Sempere M, Elias CF
Nature reviews. Endocrinology Dec 2023
(DOI : 10.1038/s41574-023-00919-z)
Maessen SE, Nichols M, Cutfield W, Norris SA, Beger C, Ong KK
BMJ (Clinical research ed.) Oct 2023
(DOI : 10.1136/bmj-2023-075736)
Associations of appetitive traits with growth velocities from infancy to childhood.
Olwi DI, Day FR, Cheng TS, Olga L, Petry CJ, Hughes IA, Smith AD, Ong KK
Scientific reports Sep 2023
(DOI : 10.1038/s41598-023-42899-0)
A comprehensive spatio-cellular map of the human hypothalamus.
Tadross JA, Steuernagel L, Dowsett GKC, Kentistou KA, Lundh S, Porniece M, Klemm P, Rainbow K, Hvid H, Kania K, Polex-Wolf J, Knudsen LB, Pyke C, Perry JRB, Lam BYH, Brüning JC, Yeo GSH, Kentistou K, Perry JR
Nature Sep 2023
(DOI : 10.1038/s41586-024-08504-8)
Shared and distinct genetic etiologies for different types of clonal hematopoiesis.
Brown DW, Cato LD, Zhao Y, Nandakumar SK, Bao EL, Gardner EJ, Hubbard AK, DePaulis A, Rehling T, Song L, Yu K, Chanock SJ, Perry JRB, Sankaran VG, Machiela MJ
Nature communications Sep 2023
(DOI : 10.1038/s41467-023-41315-5)
Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A, Marullo L, Mägi R, Rujan RM, Ahlqvist E, Thorleifsson G, Gao Η, Εvangelou Ε, Benyamin B, Scott RA, Isaacs A, Zhao JH, Willems SM, Johnson T, Gieger C, Grallert H, Meisinger C, Müller-Nurasyid M, Strawbridge RJ, Goel A, Rybin D, Albrecht E, Jackson AU, Stringham HM, Corrêa IR, Farber-Eger E, Steinthorsdottir V, Uitterlinden AG, Munroe PB, Brown MJ, Schmidberger J, Holmen O, Thorand B, Hveem K, Wilsgaard T, Mohlke KL, Wang Z, GWA-PA Consortium GWA-PA Consortium, Shmeliov A, den Hoed M, Loos RJF, Kratzer W, Haenle M, Koenig W, Boehm BO, Tan TM, Tomas A, Salem V, Barroso I, Tuomilehto J, Boehnke M, Florez JC, Hamsten A, Watkins H, Njølstad I, Wichmann HE, Caulfield MJ, Khaw KT, van Duijn CM, Hofman A, Wareham NJ, Langenberg C, Whitfield JB, Martin NG, Montgomery G, Scapoli C, Tzoulaki I, Elliott P, Thorsteinsdottir U, Stefansson K, Brittain EL, McCarthy MI, Froguel P, Sexton PM, Wootten D, Groop L, Dupuis J, Meigs JB, Deganutti G, Demirkan A, Pers TH, Reynolds CA, Aulchenko YS, Kaakinen MA, Jones B, Prokopenko I, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC) Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)
Nature genetics Sep 2023
(DOI : 10.1038/s41588-023-01462-3)
Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.
Kaisinger LR, Kentistou KA, Stankovic S, Gardner EJ, Day FR, Zhao Y, Mörseburg A, Carnie CJ, Zagnoli-Vieira G, Puddu F, Jackson SP, O'Rahilly S, Farooqi IS, Dearden L, Pantaleão LC, Ozanne SE, Ong KK, Perry JRB
Cell genomics Aug 2023
(DOI : 10.1016/j.xgen.2023.100362)
Wilcox N, Dumont M, González-Neira A, Carvalho S, Joly Beauparlant C, Crotti M, Luccarini C, Soucy P, Dubois S, Nuñez-Torres R, Pita G, Gardner EJ, Dennis J, Alonso MR, Álvarez N, Baynes C, Collin-Deschesnes AC, Desjardins S, Becher H, Behrens S, Bolla MK, Castelao JE, Chang-Claude J, Cornelissen S, Dörk T, Engel C, Gago-Dominguez M, Guénel P, Hadjisavvas A, Hahnen E, Hartman M, Herráez B, SGBCC Investigators SGBCC Investigators, Jung A, Keeman R, Kiechle M, Li J, Loizidou MA, Lush M, Michailidou K, Panayiotidis MI, Sim X, Teo SH, Tyrer JP, van der Kolk LE, Wahlström C, Wang Q, Perry JRB, Benitez J, Schmidt MK, Schmutzler RK, Pharoah PDP, Droit A, Dunning AM, Kvist A, Devilee P, Easton DF, Simard J
Nature genetics Aug 2023
(DOI : 10.1038/s41588-023-01466-z)
Genetic impacts on DNA methylation help elucidate regulatory genomic processes.
Villicaña S, Castillo-Fernandez J, Hannon E, Christiansen C, Tsai PC, Maddock J, Kuh D, Suderman M, Power C, Relton C, Ploubidis G, Wong A, Hardy R, Goodman A, Ong KK, Bell JT
Genome biology Jul 2023
(DOI : 10.1186/s13059-023-03011-x)
Causal associations between cardiorespiratory fitness and type 2 diabetes.
Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S, Wareham NJ
Nature communications Jul 2023
(DOI : 10.1038/s41467-023-38234-w)
Canton APM, Tinano FR, Guasti L, Montenegro LR, Ryan F, Shears D, de Melo ME, Gomes LG, Piana MP, Brauner R, Espino-Aguilar R, Escribano-Muñoz A, Paganoni A, Read JE, Korbonits M, Seraphim CE, Costa SS, Krepischi AC, Jorge AAL, David A, Kaisinger LR, Ong KK, Perry JRB, Abreu AP, Kaiser UB, Argente J, Mendonca BB, Brito VN, Howard SR, Latronico AC
The lancet. Diabetes & endocrinology Jun 2023
(DOI : 10.1016/S2213-8587(23)00131-6)
Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency.
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, Day FR, Baptista J, Wright CF, Weedon MN, Hoffmann ER, Ruth KS, Ong KK, Perry JRB, Murray A
Nature medicine Jun 2023
(DOI : 10.1038/s41591-023-02405-5)
Duckett K, Williamson A, Kincaid JWR, Rainbow K, Corbin LJ, Martin HC, Eberhardt RY, Huang QQ, Hurles ME, He W, Brauner R, Delaney A, Dunkel L, Grinspon RP, Hall JE, Hirschhorn JN, Howard SR, Latronico AC, Jorge AAL, McElreavey K, Mericq V, Merino PM, Palmert MR, Plummer L, Rey RA, Rezende RC, Seminara SB, Salnikov K, Banerjee I, Lam BYH, Perry JRB, Timpson NJ, Clayton P, Chan YM, Ong KK, O'Rahilly S
The Journal of clinical endocrinology and metabolism Jun 2023
(DOI : 10.1210/clinem/dgad373)
Nyati LH, Pettifor JM, Ong KK, Norris SA
European Journal of Clinical Nutrition Jun 2023
(DOI : 10.1038/s41430-023-01293-9)
Cheng TS, Brage S, van Sluijs EMF, Ong KK
International Journal of Epidemiology May 2023
(DOI : 10.1093/ije/dyad063)
Eleftheriou A, Ong KK, Hughes IA, Petry CJ
The Journal of clinical endocrinology and metabolism May 2023
(DOI : 10.1210/clinem/dgad263)
Effect of Growth Hormone Therapy on Pubertal Timing: Systematic Review and Meta-analysis.
Hormone research in paediatrics Apr 2023
(DOI : 10.1159/000530578)
Chichlowski M, van Diepen JA, Prodan A, Olga L, Ong KK, Kortman GAM, Dunger DB, Gross G
Frontiers in nutrition Mar 2023
(DOI : 10.3389/fnut.2023.1003032)
Ku CW, Cheng TS, Ku CO, Zhou KX, Cheung YB, Godfrey KM, Han WM, Yap F, Chan JKY, Loy SL
Scientific reports Mar 2023
(DOI : 10.1038/s41598-023-31954-5)
Andrews A, Cottrell E, Maharaj A, Ladha T, Williams J, Schilbach K, Kaisinger LR, Perry JRB, Metherell LA, McCormick PJ, Storr HL
European journal of endocrinology Mar 2023
(DOI : 10.1093/ejendo/lvad039)
Mathieson I, Day FR, Barban N, Tropf FC, Brazel DM, eQTLGen Consortium eQTLGen Consortium, BIOS consortium BIOS consortium, Vaez A, van Zuydam N, Bitarello BD, Gardner EJ, Akimova ET, Azad A, Bergmann S, Bielak LF, Boomsma DI, Bosak K, Brumat M, Buring JE, Cesarini D, Chasman DI, Chavarro JE, Cocca M, Concas MP, Davey Smith G, Davies G, Deary IJ, Esko T, Faul JD, FinnGen Study FinnGen Study, Franco O, Ganna A, Gaskins AJ, Gelemanovic A, de Geus EJC, Gieger C, Girotto G, Gopinath B, Grabe HJ, Gunderson EP, Hayward C, He C, van Heemst D, Hill WD, Hoffmann ER, Homuth G, Hottenga JJ, Huang H, Hyppӧnen E, Ikram MA, Jansen R, Johannesson M, Kamali Z, Kardia SLR, Kavousi M, Kifley A, Kiiskinen T, Kraft P, Kühnel B, Langenberg C, Liew G, Lifelines Cohort Study Lifelines Cohort Study, Lind PA, Luan J, Mägi R, Magnusson PKE, Mahajan A, Martin NG, Mbarek H, McCarthy MI, McMahon G, Medland SE, Meitinger T, Metspalu A, Mihailov E, Milani L, Missmer SA, Mitchell P, Møllegaard S, Mook-Kanamori DO, Morgan A, van der Most PJ, de Mutsert R, Nauck M, Nolte IM, Noordam R, Penninx BWJH, Peters A, Peyser PA, Polasek O, Power C, Pribisalic A, Redmond P, Rich-Edwards JW, Ridker PM, Rietveld CA, Ring SM, Rose LM, Rueedi R, Shukla V, Smith JA, Stankovic S, Stefansson K, Stöckl D, Strauch K, Swertz MA, Teumer A, Thorleifsson G, Thorsteinsdottir U, Thurik AR, Timpson NJ, Turman C, Uitterlinden AG, Waldenberger M, Wareham NJ, Weir DR, Willemsen G, Zhao JH, Zhao W, Zhao Y, Snieder H, den Hoed M, Ong KK, Mills MC, Perry JRB
Nature Human Behaviour Mar 2023
(DOI : 10.1038/s41562-023-01528-6)
Butyrate in Human Milk: Associations with Milk Microbiota, Milk Intake Volume, and Infant Growth.
Olga L, van Diepen JA, Chichlowski M, Petry CJ, Vervoort J, Dunger DB, Kortman GAM, Gross G, Ong KK
Nutrients Feb 2023
(DOI : 10.3390/nu15040916)
Kentistou KA, Luan J, Wittemans LBL, Hambly C, Klaric L, Kutalik Z, Speakman JR, Wareham NJ, Kendall TJ, Langenberg C, Wilson JF, Joshi PK, Morton NM
Nature communications Jan 2023
(DOI : 10.1038/s41467-022-35563-0)
Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ, Langenberg C, O'Rahilly S, Ong KK, Perry JRB
Cell genomics Dec 2022
(DOI : 10.1016/j.xgen.2022.100208)
Variants in CLDN5 cause a syndrome characterized by seizures, microcephaly and brain calcifications.
Deshwar AR, Cytrynbaum C, Murthy H, Zon J, Chitayat D, Volpatti J, Newbury-Ecob R, Ellard S, Lango Allen H, Yu EP, Noche R, Walker S, Scherer SW, Mahida S, Elitt CM, Nicolas G, Goldenberg A, Saugier-Veber P, Lecoquierre F, Dabaj I, Meddaugh H, Marble M, Keppler-Noreuil KM, Drayson L, Barañano KW, Chassevent A, Agre K, Létard P, Bilan F, Le Guyader G, Laquerrière A, Ramsey K, Henderson L, Brady L, Tarnopolsky M, Bainbridge M, Friedman J, Capri Y, Athayde L, Kok F, Gurgel-Giannetti J, Ramos LLP, Blaser S, Dowling JJ, Weksberg R
Brain : a journal of neurology Dec 2022
(DOI : 10.1093/brain/awac461)
Olga L, Vervoort J, van Diepen JA, Gross G, Petry CJ, Prentice PM, Chichlowski M, van Tol EA, Hughes IA, Dunger DB, Ong KK
The British journal of nutrition Oct 2022
(DOI : 10.1017/S0007114522003178)
Buhmeida A, Assidi M, Alyazidi O, Olwi DI, Althuwaylimi A, Yahya FM, Arfaoui L, Merdad L, Abuzenadah AM
International Journal of Environmental Research and Public Health Oct 2022
(DOI : 10.3390/ijerph191911872)
Lipid profiling analyses from mouse models and human infants.
Olga L, Bobeldijk-Pastorova I, Bas RC, Seidel F, Snowden SG, Furse S, Ong KK, Kleemann R, Koulman A
STAR protocols Sep 2022
(DOI : 10.1016/j.xpro.2022.101679)
Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with mutations.
Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC
Science immunology Aug 2022
(DOI : 10.1126/sciimmunol.abn3800)
Ong YY, Tint MT, Aris IM, Yuan WL, Chen LW, Fortier MV, Choo J, Ling LH, Shek L, Tan KH, Gluckman PD, Yap F, Chong YS, Godfrey KM, Chong MF, Chan SY, Eriksson JG, Wlodek ME, De Lucia Rolfe E, Ong KK, Michael N, Lee YS
International Journal of Epidemiology Jul 2022
(DOI : 10.1093/ije/dyac154)
Early weight gain influences duration of breast feeding: prospective cohort study.
Olga L, van Diepen JA, Gross G, Dunger DB, Ong KK
Archives of Disease in Childhood Jul 2022
(DOI : 10.1136/archdischild-2022-323999)
Mauschitz MM, Verzijden T, Schuster AK, Elbaz H, Pfeiffer N, Khawaja A, Luben RN, Foster PJ, Rauscher FG, Wirkner K, Kirsten T, Jonas JB, Bikbov MM, Hogg R, Peto T, Cougnard-Gregoire A, Bertelsen G, Erke MG, Topouzis F, Giannoulis DA, Brandl C, Heid IM, Creuzot-Garcher CP, Gabrielle PH, Hense HW, Pauleikhoff D, Barreto P, Coimbra R, Piermarocchi S, Daien V, Holz FG, Delcourt C, Finger RP, European Eye Epidemiology (E3) Consortium European Eye Epidemiology (E3) Consortium
The British journal of ophthalmology Jun 2022
(DOI : 10.1136/bjo-2022-321985)
Detection and characterization of male sex chromosome abnormalities in the UK Biobank study.
Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Lango Allen H, Day FR, Langenberg C, Frayling TM, Weedon MN, Perry JRB, Ong KK, Murray A
Genetics in medicine : official journal of the American College of Medical Genetics Jun 2022
(DOI : 10.1016/j.gim.2022.05.011)
Pirastu N, McDonnell C, Grzeszkowiak EJ, Mounier N, Imamura F, Merino J, Day FR, Zheng J, Taba N, Concas MP, Repetto L, Kentistou KA, Robino A, Esko T, Joshi PK, Fischer K, Ong KK, Gaunt TR, Kutalik Z, Perry JRB, Wilson JF
PLoS genetics Jun 2022
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Petry CJ, Olga L, Hughes IA, Ong KK
PLoS ONE May 2022
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Adverse Effects of Early Puberty Timing in Girls and Potential Solutions.
Journal of pediatric and adolescent gynecology May 2022
(DOI : 10.1016/j.jpag.2022.05.005)
Prioreschi A, Ong KK, Rolfe EL, Westgate K, Micklesfield LK, Brage S
Maternal and Child Health Journal May 2022
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Maternal Paracetamol Intake During Pregnancy-Impacts on Offspring Reproductive Development.
Tadokoro-Cuccaro R, Fisher BG, Thankamony A, Ong KK, Hughes IA
Frontiers in toxicology Feb 2022
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Biology of sex differences Feb 2022
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Trends towards earlier puberty timing in girls and its likely mechanisms.
Journal of pediatric and adolescent gynecology Feb 2022
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Hunter KE, Johnson BJ, Askie L, Golley RK, Baur LA, Marschner IC, Taylor RW, Wolfenden L, Wood CT, Mihrshahi S, Hayes AJ, Rissel C, Robledo KP, O'Connor DA, Espinoza D, Staub LP, Chadwick P, Taki S, Barba A, Libesman S, Aberoumand M, Smith WA, Sue-See M, Hesketh KD, Thomson JL, Bryant M, Paul IM, Verbestel V, Stough CO, Wen LM, Larsen JK, O'Reilly SL, Wasser HM, Savage JS, Ong KK, Salvy SJ, Messito MJ, Gross RS, Karssen LT, Rasmussen FE, Campbell K, Linares AM, Øverby NC, Palacios C, Joshipura KJ, González Acero C, Lakshman R, Thompson AL, Maffeis C, Oken E, Ghaderi A, Campos Rivera M, Pérez-Expósito AB, Banna JC, de la Haye K, Goran M, Røed M, Anzman-Frasca S, Taylor BJ, Seidler AL, Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration
BMJ Open Jan 2022
(DOI : 10.1136/bmjopen-2020-048166)
van Beijsterveldt IALP, Myers PN, Snowden SG, Ong KK, Brix S, Hokken-Koelega ACS, Koulman A
Clinical nutrition (Edinburgh, Scotland) Jan 2022
(DOI : 10.1016/j.clnu.2022.04.015)
Ochoa E, Lee S, Lan-Leung B, Dias RP, Ong KK, Radley JA, Pérez de Nanclares G, Martinez R, Clark G, Martin E, Castaño L, Bottolo L, Maher ER
Genetics in medicine : official journal of the American College of Medical Genetics Oct 2021
(DOI : 10.1016/j.gim.2021.10.011)
Metabolomics in early life and the association with body composition at age 2 years.
van Beijsterveldt IALP, Snowden SG, Myers PN, de Fluiter KS, van de Heijning B, Brix S, Ong KK, Dunger DB, Hokken-Koelega ACS, Koulman A
Pediatric Obesity Aug 2021
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Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study.
Larsson SC, Kar S, Perry JRB, Carter P, Vithayathil M, Mason AM, Easton DF, Burgess S
The Journal of clinical endocrinology and metabolism Jul 2021
(DOI : 10.1210/clinem/dgab713)
Olga L, Petry CJ, van Diepen JA, Prentice PM, Hughes IA, Vervoort J, Boekhorst J, Chichlowski M, Gross G, Dunger DB, Ong KK
Nutrients Jul 2021
(DOI : 10.3390/nu13082879)
Wielscher M, Mandaviya PR, Kuehnel B, Joehanes R, Mustafa R, Robinson O, Zhang Y, Bodinier B, Walton E, Mishra PP, Schlosser P, Wilson R, Tsai PC, Palaniswamy S, Marioni RE, Fiorito G, Cugliari G, Karhunen V, Ghanbari M, Psaty BM, Loh M, Bis JC, Lehne B, Sotoodehnia N, Deary IJ, Chadeau-Hyam M, Brody JA, Cardona A, Selvin E, Smith AK, Miller AH, Torres MA, Marouli E, Gào X, van Meurs JBJ, Graf-Schindler J, Rathmann W, Koenig W, Peters A, Weninger W, Farlik M, Zhang T, Chen W, Xia Y, Teumer A, Nauck M, Grabe HJ, Doerr M, Lehtimäki T, Guan W, Milani L, Tanaka T, Fisher K, Waite LL, Kasela S, Vineis P, Verweij N, van der Harst P, Iacoviello L, Sacerdote C, Panico S, Krogh V, Tumino R, Tzala E, Matullo G, Hurme MA, Raitakari OT, Colicino E, Baccarelli AA, Kähönen M, Herzig KH, Li S, BIOS consortium BIOS consortium, Conneely KN, Kooner JS, Köttgen A, Heijmans BT, Deloukas P, Relton C, Ong KK, Bell JT, Boerwinkle E, Elliott P, Brenner H, Beekman M, Levy D, Waldenberger M, Chambers JC, Dehghan A, Järvelin MR
Nature communications Jul 2021
(DOI : 10.1038/s41467-022-29792-6)
Petry CJ, Ong KK, Hughes IA, Dunger DB
Nutrients May 2021
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Lin SH, Brown DW, Rose B, Day F, Lee OW, Khan SM, Hislop J, Chanock SJ, Perry JRB, Machiela MJ
Cell & bioscience Apr 2021
(DOI : 10.1186/s13578-021-00651-z)
Cheng TS, Day FR, Perry JRB, Luan J, Langenberg C, Forouhi NG, Wareham NJ, Ong KK
Nutrients Apr 2021
(DOI : 10.3390/nu13061868)
Olga L, van Beijsterveldt IALP, Hughes IA, Dunger DB, Ong KK, Hokken-Koelega ACS, De Lucia Rolfe E
Pediatric Obesity Apr 2021
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Durham SD, Robinson RC, Olga L, Ong KK, Chichlowski M, Dunger DB, Barile D
Glycobiology Mar 2021
(DOI : 10.1093/glycob/cwab057)
Guivarch C, Charles MA, Forhan A, Ong KK, Heude B, de Lauzon-Guillain B
Nutrients Mar 2021
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Norris T, Mansukoski L, Gilthorpe MS, Hamer M, Hardy R, Howe LD, Hughes AD, Li L, O'Donnell E, Ong KK, Ploubidis GB, Silverwood RJ, Viner RM, Johnson W
Arteriosclerosis, thrombosis, and vascular biology Mar 2021
(DOI : 10.1161/ATVBAHA.120.315782)
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health.
Zhao Y, Stankovic S, Koprulu M, Wheeler E, Day FR, Lango Allen H, Kerrison ND, Pietzner M, Loh PR, Wareham NJ, Langenberg C, Ong KK, Perry JRB
Nature communications Feb 2021
(DOI : 10.1038/s41467-021-24504-y)
A Polygenic Risk Score to Predict Future Adult Short Stature Among Children.
Lu T, Forgetta V, Wu H, Perry JRB, Ong KK, Greenwood CMT, Timpson NJ, Manousaki D, Richards JB
The Journal of clinical endocrinology and metabolism Feb 2021
(DOI : 10.1210/clinem/dgab215)
Jones D, De Lucia Rolfe E, Rennie KL, Griep LMO, Kusinski LC, Hughes DJ, Brage S, Ong KK, Beardsall K, Meek CL
Nutrients Jan 2021
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An investigation of the diet, exercise, sleep, BMI, and health outcomes of autistic adults.
Weir E, Allison C, Ong KK, Baron-Cohen S
Molecular autism Jan 2021
(DOI : 10.1186/s13229-021-00441-x)
Norris T, Hamer M, Hardy R, Li L, Ong KK, Ploubidis GB, Viner R, Johnson W
BMC medicine Dec 2020
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MC3R links nutritional state to childhood growth and the timing of puberty.
Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Genes & Health Research Team, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O'Rahilly S
Nature Dec 2020
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Fraszczyk E, Spijkerman AMW, Zhang Y, Brandmaier S, Day FR, Zhou L, Wackers P, Dollé MET, Bloks VW, Gào X, Gieger C, Kooner J, Kriebel J, Picavet HSJ, Rathmann W, Schöttker B, Loh M, Verschuren WMM, Van Vliet-Ostaptchouk JV, Wareham NJ, Chambers JC, Ong KK, Grallert H, Brenner H, Luijten M, Snieder H
Diabetologia Dec 2020
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Early childhood weight gain: Latent patterns and body composition outcomes.
Norris T, Mansukoski L, Gilthorpe MS, Hamer M, Hardy R, Howe LD, Li L, Ong KK, Ploubidis GB, Viner RM, Johnson W
Paediatric and perinatal epidemiology Nov 2020
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Cheng TS, Sharp SJ, Brage S, Emmett PM, Forouhi NG, Ong KK
European journal of nutrition Nov 2020
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Eleftheriou A, Petry CJ, Hughes IA, Ong KK, Dunger DB
Diabetes care Nov 2020
(DOI : 10.2337/dc20-2820)
Petry CJ, Ong KK, Hughes IA, Dunger DB
BMC research notes Nov 2020
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A Novel method for the identification and quantification of weight faltering.
Naumenko DJ, Dykes J, O'Connor GK, Stanley Z, Affara N, Doel AM, Drammeh S, Dunger DB, Faal A, Ong KK, Sosseh F, Prentice AM, Moore SE, Bernstein RM
American journal of physical anthropology Nov 2020
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GLP-1 agonists for obesity and type 2 diabetes in children: Systematic review and meta-analysis.
Obesity reviews : an official journal of the International Association for the Study of Obesity Nov 2020
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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression.
Dumanski JP, Halvardson J, Davies H, Rychlicka-Buniowska E, Mattisson J, Moghadam BT, Nagy N, Węglarczyk K, Bukowska-Strakova K, Danielsson M, Olszewski P, Piotrowski A, Oerton E, Ambicka A, Przewoźnik M, Bełch Ł, Grodzicki T, Chłosta PL, Imreh S, Giedraitis V, Kilander L, Nordlund J, Ameur A, Gyllensten U, Johansson Å, Józkowicz A, Siedlar M, Klich-Rączka A, Jaszczyński J, Enroth S, Baran J, Ingelsson M, Perry JRB, Ryś J, Forsberg LA
Cellular and molecular life sciences : CMLS Oct 2020
(DOI : 10.1007/s00018-021-03822-w)
Quilter CR, Harvey KM, Bauer J, Skinner BM, Gomez M, Shrivastava M, Doel AM, Drammeh S, Dunger DB, Moore SE, Ong KK, Prentice AM, Bernstein RM, Sargent CA, Affara NA
FASEB bioAdvances Oct 2020
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Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.
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Nature genetics Oct 2020
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Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.
Portilla-Fernandez E, Hwang SJ, Wilson R, Maddock J, Hill WD, Teumer A, Mishra PP, Brody JA, Joehanes R, Ligthart S, Ghanbari M, Kavousi M, Roks AJM, Danser AHJ, Levy D, Peters A, Ghasemi S, Schminke U, Dörr M, Grabe HJ, Lehtimäki T, Kähönen M, Hurme MA, Bartz TM, Sotoodehnia N, Bis JC, Thiery J, Koenig W, Ong KK, Bell JT, Meisinger C, Wardlaw JM, Starr JM, Seissler J, Then C, Rathmann W, Ikram MA, Psaty BM, Raitakari OT, Völzke H, Deary IJ, Wong A, Waldenberger M, O'Donnell CJ, Dehghan A
European Journal of Epidemiology Oct 2020
(DOI : 10.1007/s10654-021-00759-z)
Petry CJ, Ong KK, Hughes IA, Dunger DB
Nutrients Sep 2020
(DOI : 10.3390/nu12113466)
Olga L, van Diepen JA, Bobeldijk-Pastorova I, Gross G, Prentice PM, Snowden SG, Furse S, Kooistra T, Hughes IA, Schoemaker MH, van Tol EAF, van Duyvenvoorde W, Wielinga PY, Ong KK, Dunger DB, Kleemann R, Koulman A
EBioMedicine Sep 2020
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