MRC Epidemiology Unit

 

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.

Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S

Nature metabolism. Sep 2024

(DOI : 10.1038/s42255-024-01126-4)

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Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause.

Yazdanpanah M, Yazdanpanah N, Gamache I, Ong K, Perry JRB, Manousaki D

Genome medicine. May 2024

(DOI : 10.1186/s13073-024-01322-7)

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Effect of Growth Hormone Therapy on Pubertal Timing: Systematic Review and Meta-analysis.

Olwi D, Day F, Ong K

Hormone research in paediatrics. Apr 2023

(DOI : 10.1159/000530578)

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Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

Day F, Karaderi T, Jones MR, Meun C, He C, Drong A, Kraft P, Lin N, Huang H, Broer L, Mägi R, Saxena R, Laisk T, Urbanek M, Hayes MG, Thorleifsson G, Fernandez-Tajes J, Mahajan A, Mullin BH, Stuckey BGA, Spector TD, Wilson SG, Goodarzi MO, Davis L, Obermayer-Pietsch B, Uitterlinden AG, Anttila V, Neale BM, Järvelin MR, Fauser B, Kowalska I, Visser JA, Andersen M, Ong K, Stener-Victorin E, Ehrmann D, Legro RS, Salumets A, McCarthy MI, Morin-Papunen L, Thorsteinsdottir U, Stefansson K, 23andMe Research Team, Styrkarsdottir U, Perry JRB, Dunaif A, Laven J, Franks S, Lindgren CM, Welt CK

PLoS genetics. Apr 2018

(DOI : 10.1371/journal.pgen.1007813)

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Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children.

Mäntyselkä A, Jääskeläinen J, Eloranta AM, Väistö J, Voutilainen R, Ong K, Brage S, Lakka TA, Lindi V

Clinical endocrinology. May 2017

(DOI : 10.1111/cen.13511)

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The translation of lipid profiles to nutritional biomarkers in the study of infant metabolism.

Acharjee A, Prentice P, Acerini C, Smith J, Hughes IA, Ong K, Griffin JL, Dunger D, Koulman A

Metabolomics : Official journal of the Metabolomic Society. Nov 2016

(DOI : 10.1007/s11306-017-1166-2)

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Clustering of cardio-metabolic risk factors in parents of adolescents with type 1 diabetes and microalbuminuria.

Marcovecchio ML, Tossavainen PH, Owen K, Fullah C, Benitez-Aguirre P, Masi S, Ong K, Nguyen H, Chiesa ST, Dalton RN, Deanfield J, Dunger DB

Pediatric diabetes. Sep 2016

(DOI : 10.1111/pedi.12515)

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Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.

Beaney KE, Smith AJP, Folkersen L, Palmen J, Wannamethee SG, Jefferis BJ, Whincup P, Gaunt TR, Casas JP, Ben-Shlomo Y, Price JF, Kumari M, Wong A, Ong K, Hardy R, Kuh D, Wareham N, Kivimaki M, Eriksson P, Humphries SE, Consortium U

Disease markers. Aug 2016

(DOI : 10.1155/2017/1096916)

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Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, Shah S, Kruger FA, Giambartolomei C, Swerdlow DI, Palmer T, McLachlan S, Langenberg C, Zabaneh D, Lovering R, Cavadino A, Jefferis B, Finan C, Wong A, Amuzu A, Ong K, Gaunt TR, Warren H, Davies TL, Drenos F, Cooper J, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hyppönen E, Richards M, Hardy R, Kuh D, Wareham N, Ben-Shlomo Y, Day IN, Whincup P, Morris R, Strachan MW, Price J, Kumari M, Kivimaki M, Plagnol V, Whittaker JC, International Consortium for Blood Pressure (ICBP), Smith GD, Dudbridge F, Casas JP, Holmes MV, Hingorani AD, UCLEB (University College London-London School of Hygiene & Tropical Medicine-Edinburgh-Bristol Consortium

The lancet. Diabetes & endocrinology. Apr 2015

(DOI : 10.1016/S2213-8587(15)00386-1)

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Population genomics of cardiometabolic traits: design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D, Cavadino A, Finan C, Wong A, Amuzu A, Ong K, Gaunt T, Holmes MV, Warren H, Swerdlow DI, Davies TL, Drenos F, Cooper J, Sofat R, Caulfield M, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hyppönen E, Richards M, Hardy R, Kuh D, Wareham NJ, Langenberg C, Ben-Shlomo Y, Day IN, Whincup P, Morris R, Strachan MW, Price J, Kumari M, Kivimaki M, Plagnol V, Dudbridge F, Whittaker JC, Casas JP, Hingorani AD

PLoS ONE. Feb 2013

(DOI : 10.1371/journal.pone.0071345)

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Protocol for systematic reviews of determinants/correlates of obesity-related dietary and physical activity behaviors in young children (preschool 0 to 6 years): evidence mapping and syntheses.

Lakshman R, Mazarello Paes V, Hesketh KR, O'Malley C, Moore H, Ong K, Griffin S, van Sluijs E, Summerbell C

Systematic Reviews. Feb 2013

(DOI : 10.1186/2046-4053-2-28)

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Assessment of childhood obesity in secondary care: OSCA consensus statement.

Viner RM, White B, Barrett T, Candy DC, Gibson P, Gregory JW, Matyka K, Ong K, Roche E, Rudolf MC, Shaikh G, Shield JP, Wales JK

Archives of disease in childhood. Education and practice edition. May 2012

(DOI : 10.1136/edpract-2011-301426)

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Piecing together the FTO jigsaw.

Frayling TM, Ong K

Genome biology. Feb 2011

(DOI : 10.1186/gb-2011-12-2-104)

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Child health, developmental plasticity, and epigenetic programming.

Hochberg Z, Feil R, Constância M, Fraga M, Junien C, Carel JC, Boileau P, Le Bouc Y, Deal CL, Lillycrop K, Scharfmann R, Sheppard A, Skinner M, Szyf M, Waterland RA, Waxman DJ, Whitelaw E, Ong K, Albertsson-Wikland K

Endocrine reviews. Oct 2010

(DOI : 10.1210/er.2009-0039)

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Prevalence and determinants of hyperglycemia in very low birth weight infants: cohort analyses of the NIRTURE study.

Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, Vanhole C, Palmer CR, Ong K, vanWeissenbruch M, Midgley P, Thompson M, Thio M, Cornette L, Ossuetta I, Iglesias I, Theyskens C, de Jong M, Gill B, Ahluwalia JS, de Zegher F, Dunger DB

The Journal of pediatrics. Aug 2009

(DOI : 10.1016/j.jpeds.2010.04.032)

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Adult stature and diabetes complications in patients with type 1 diabetes: the FinnDiane Study and the diabetes control and complications trial.

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Hietala K, Ong K, Wareham NJ, Groop PH

Diabetes. Jun 2009

(DOI : 10.2337/db08-1767)

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Metabolic syndrome in children: comparison of the International Diabetes Federation 2007 consensus with an adapted National Cholesterol Education Program definition in 300 overweight and obese French children.

Druet C, Ong K, Levy Marchal C

Hormone research in paediatrics. Jul 2008

(DOI : 10.1159/000284359)

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The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes.

Amin R, Frystyk J, Ong K, Dalton RN, Flyvbjerg A, Dunger DB

Diabetologia. Feb 2008

(DOI : 10.1007/s00125-008-1081-1)

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Elevated blood pressure in overweight and obese Irish children.

Finucane FM, Pittock S, Fallon M, Hatunic M, Ong K, Burns N, Costigan C, Murphy N, Nolan JJ

Irish journal of medical science. Dec 2007

(DOI : 10.1007/s11845-008-0228-x)

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Persisting benefits 12-18 months after discontinuation of pubertal metformin therapy in low birthweight girls.

Ong K, de Zegher F, Valls C, Dunger DB, Ibáñez L

Clinical endocrinology. Jul 2007

(DOI : 10.1111/j.1365-2265.2007.02952.x)

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Longitudinal changes in insulin-like growth factor-I, insulin sensitivity, and secretion from birth to age three years in small-for-gestational-age children.

Iñiguez G, Ong K, Bazaes R, Avila A, Salazar T, Dunger D, Mericq V

The Journal of clinical endocrinology and metabolism. Aug 2006

(DOI : 10.1210/jc.2006-0844)

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Metformin treatment to prevent early puberty in girls with precocious pubarche.

Ibáñez L, Ong K, Valls C, Marcos MV, Dunger DB, de Zegher F

The Journal of clinical endocrinology and metabolism. May 2006

(DOI : 10.1210/jc.2006-0336)

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Effects of growth hormone treatment on neutrophil count in children born small for gestational age.

Ibáñez L, Ong K, Dunger DB, Zegher Fd

Pediatrics. May 2006

(DOI : 10.1542/peds.2006-0022)

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Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children.

Ibáñez L, Ong K, Dunger DB, de Zegher F

The Journal of clinical endocrinology and metabolism. Mar 2006

(DOI : 10.1210/jc.2005-2778)

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Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty.

Ibáñez L, Valls C, Ong K, Dunger DB, de Zegher F

The Journal of clinical endocrinology and metabolism. Feb 2006

(DOI : 10.1210/jc.2005-2329)

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Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES).

Ekelund U, Ong K, Linné Y, Neovius M, Brage S, Dunger DB, Wareham NJ, Rössner S

The American Journal of Clinical Nutrition. Feb 2006

(DOI : 10.1093/ajcn/83.2.324)

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