MRC Epidemiology Unit - Publications Database

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study => ADDITION: Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care

Association between weight change and incidence of cardiovascular disease events and mortality among adults with type 2 diabetes: a systematic review of observational studies and behavioural intervention trials.

Strelitz J, Lawlor ER, Wu Y, Estlin A, Nandakumar G, Ahern AL, Griffin SJ

Diabetologia May 2021

(DOI : 10.1007/s00125-021-05605-1)

Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial.

Strelitz J, Sharp SJ, Khunti K, Vos RC, Rutten GEHM, Webb DR, Witte DR, Sandbaek A, Wareham NJ, Griffin SJ

Diabetes, obesity & metabolism Jul 2020

(DOI : 10.1111/dom.14278)

Changes in behaviors after diagnosis of type 2 diabetes and 10-year incidence of cardiovascular disease and mortality.

Strelitz J, Ahern AL, Long GH, Boothby CE, Wareham NJ, Griffin SJ

Cardiovascular diabetology May 2019

(DOI : 10.1186/s12933-019-0902-5)

Moderate weight change following diabetes diagnosis and 10 year incidence of cardiovascular disease and mortality.

Strelitz J, Ahern AL, Long GH, Hare MJL, Irving G, Boothby CE, Wareham NJ, Griffin SJ

Diabetologia Dec 2018

(DOI : 10.1007/s00125-019-4886-1)

Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial.

Griffin SJ, Rutten GEHM, Khunti K, Witte DR, Lauritzen T, Sharp SJ, Dalsgaard EM, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, Sandbæk A

The lancet. Diabetes & endocrinology Nov 2018

(DOI : 10.1016/S2213-8587(19)30349-3)

Association Between Primary Care Practitioner Empathy and Risk of Cardiovascular Events and All-Cause Mortality Among Patients With Type 2 Diabetes: A Population-Based Prospective Cohort Study.

Dambha-Miller H, Feldman AL, Kinmonth AL, Griffin SJ

Annals of family medicine Oct 2018

(DOI : 10.1370/afm.2421)

Incremental Costs and Cost Effectiveness of Intensive Treatment in Individuals with Type 2 Diabetes Detected by Screening in the ADDITION-UK Trial: An Update with Empirical Trial-Based Cost Data.

Laxy M, Wilson ECF, Boothby CE, Griffin SJ

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research Sep 2016

(DOI : 10.1016/j.jval.2017.05.018)

Fruit and vegetable intake and cardiovascular risk factors in people with newly diagnosed type 2 diabetes.

Lamb MJE, Griffin SJ, Sharp SJ, Cooper AJ

European Journal of Clinical Nutrition Feb 2016

(DOI : 10.1038/ejcn.2016.180)

Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed Type 2 diabetes: a prospective cohort analysis.

Guo VY, Brage S, Ekelund U, Griffin SJ, Simmons RK

Diabetic medicine : a journal of the British Diabetic Association Aug 2015

(DOI : 10.1111/dme.12886)

Long-term effect of population screening for diabetes on cardiovascular morbidity, self-rated health, and health behavior.

Echouffo-Tcheugui JB, Simmons RK, Prevost AT, Williams KM, Kinmonth AL, Wareham NJ, Griffin SJ

Annals of family medicine Mar 2015

(DOI : 10.1370/afm.1737)

Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial.

Tao L, Wilson EC, Wareham NJ, Sandbaek A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

Diabetic medicine : a journal of the British Diabetic Association Feb 2015

(DOI : 10.1111/dme.12711)

Medication burden in the first 5 years following diagnosis of type 2 diabetes: findings from the ADDITION-UK trial cohort.

Black JA, Simmons RK, Boothby CE, Davies MJ, Webb D, Khunti K, Long GH, Griffin SJ

BMJ open diabetes research & care Dec 2014

(DOI : 10.1136/bmjdrc-2014-000075)

Change in cardio-protective medication and health-related quality of life after diagnosis of screen-detected diabetes: Results from the ADDITION-Cambridge cohort.

Black JA, Long GH, Sharp SJ, Kuznetsov L, Boothby CE, Griffin SJ, Simmons RK

Diabetes Research and Clinical Practice Nov 2014

(DOI : 10.1016/j.diabres.2015.04.013)

Early Detection and Treatment of Type 2 Diabetes Reduce Cardiovascular Morbidity and Mortality: A Simulation of the Results of the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen-Detected Diabetes in Primary Care (ADDITION-Europe).

Herman WH, Ye W, Griffin SJ, Simmons RK, Davies MJ, Khunti K, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Brown MB, Wareham NJ

Diabetes care Oct 2014

(DOI : 10.2337/dc14-2459)

Variation in prescribing of lipid-lowering medication in primary care is associated with incidence of cardiovascular disease and all-cause mortality in people with screen-detected diabetes: findings from the ADDITION-Denmark trial.

Simmons RK, Carlsen AH, Griffin SJ, Charles M, Christiansen JS, Borch-Johnsen K, Sandbaek A, Lauritzen T

Diabetic medicine : a journal of the British Diabetic Association Apr 2014

(DOI : 10.1111/dme.12574)

Are changes in glycaemic control associated with diabetes-specific quality of life and health status in screen-detected type 2 diabetes patients? Four-year follow up of the ADDITION-Cambridge cohort.

Kuznetsov L, Long GH, Griffin SJ, Simmons RK

Diabetes/metabolism research and reviews Nov 2013

(DOI : 10.1002/dmrr.2559)

Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care.

Johansen NB, Hansen AL, Jensen TM, Philipsen A, Rasmussen SS, Jørgensen ME, Simmons RK, Lauritzen T, Sandbæk A, Witte DR

BMC Public Health Nov 2012

(DOI : 10.1186/1471-2458-12-1078)

Screening for type 2 diabetes and population mortality over 10 years (ADDITION-Cambridge): a cluster-randomised controlled trial.

Simmons RK, Echouffo-Tcheugui JB, Sharp SJ, Sargeant LA, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ

Lancet (London, England) Oct 2012

(DOI : 10.1016/S0140-6736(12)61422-6)

Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial.

Simmons RK, Sharp SJ, Sandbæk A, Borch-Johnsen K, Davies MJ, Khunti K, Lauritzen T, Rutten GE, van den Donk M, Wareham NJ, Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association Jul 2012

(DOI : 10.1111/j.1464-5491.2012.03759.x)

Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial.

Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, Lauritzen T

Lancet (London, England) Jun 2011

(DOI : 10.1016/S0140-6736(11)60698-3)

Screening for type 2 diabetes. Lessons from the ADDITION-Europe study.

van den Donk M, Sandbaek A, Borch-Johnsen K, Lauritzen T, Simmons RK, Wareham NJ, Griffin SJ, Davies MJ, Khunti K, Rutten GE

Diabetic medicine : a journal of the British Diabetic Association Jun 2011

(DOI : 10.1111/j.1464-5491.2011.03365.x)

Predictors of anxiety and depression among people attending diabetes screening: a prospective cohort study embedded in the ADDITION (Cambridge) randomized control trial.

Paddison CA, Eborall HC, French DP, Kinmonth AL, Prevost AT, Griffin SJ, Sutton S

British journal of health psychology Jan 2011

(DOI : 10.1348/135910710X495366)

Screening for diabetes using an oral glucose tolerance test within a western multi-ethnic population identifies modifiable cardiovascular risk: the ADDITION-Leicester study.

Webb DR, Gray LJ, Khunti K, Srinivasan B, Taub N, Campbell S, Barnett J, Farooqi A, Echouffo-Tcheugui JB, Griffin SJ, Wareham NJ, Davies MJ

Diabetologia Oct 2010

(DOI : 10.1007/s00125-011-2189-2)

Who attends a UK diabetes screening programme? Findings from the ADDITION-Cambridge study.

Sargeant LA, Simmons RK, Barling RS, Butler R, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association Aug 2010

(DOI : 10.1111/j.1464-5491.2010.03056.x)

More than measurement: practice team experiences of screening for type 2 diabetes.

Graffy J, Grant J, Williams K, Cohn S, Macbay S, Griffin SJ, Kinmonth AL

Family practice Apr 2010

(DOI : 10.1093/fampra/cmq022)

Are people with negative diabetes screening tests falsely reassured? Parallel group cohort study embedded in the ADDITION (Cambridge) randomised controlled trial.

Paddison CA, Eborall HC, Sutton S, French DP, Vasconcelos J, Prevost AT, Kinmonth AL, Griffin SJ

BMJ (Clinical research ed.) Dec 2009

(DOI : 10.1136/bmj.b4535)

Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening.

Webb DR, Khunti K, Srinivasan B, Gray LJ, Taub N, Campbell S, Barnett J, Henson J, Hiles S, Farooqi A, Griffin SJ, Wareham NJ, Davies MJ

Trials Nov 2009

(DOI : 10.1186/1745-6215-11-16)

The ADDITION-Cambridge trial protocol: a cluster -- randomised controlled trial of screening for type 2 diabetes and intensive treatment for screen-detected patients.

Echouffo-Tcheugui JB, Simmons RK, Williams KM, Barling RS, Prevost AT, Kinmonth AL, Wareham NJ, Griffin SJ

BMC Public Health Mar 2009

(DOI : 10.1186/1471-2458-9-136)

How much might cardiovascular disease risk be reduced by intensive therapy in people with screen-detected diabetes?

Echouffo-Tcheugui JB, Sargeant LA, Prevost AT, Williams KM, Barling RS, Butler R, Fanshawe T, Kinmonth AL, Wareham NJ, Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association Dec 2008

(DOI : 10.1111/j.1464-5491.2008.02600.x)

Screening for type 2 diabetes is feasible, acceptable, but associated with increased short-term anxiety: a randomised controlled trial in British general practice.

Park P, Simmons RK, Prevost AT, Griffin SJ

BMC Public Health Apr 2008

(DOI : 10.1186/1471-2458-8-350)

Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study.

Sandbaek A, Griffin SJ, Rutten G, Davies M, Stolk R, Khunti K, Borch-Johnsen K, Wareham NJ, Lauritzen T

Diabetologia Oct 2007

(DOI : 10.1007/s00125-008-1013-0)

Patients' experiences of screening for type 2 diabetes: prospective qualitative study embedded in the ADDITION (Cambridge) randomised controlled trial.

Eborall H, Davies R, Kinmonth AL, Griffin SJ, Lawton J

BMJ (Clinical research ed.) Sep 2007

(DOI : 10.1136/bmj.39308.392176.BE)

Psychological impact of screening for type 2 diabetes: controlled trial and comparative study embedded in the ADDITION (Cambridge) randomised controlled trial.

Eborall HC, Griffin SJ, Prevost AT, Kinmonth AL, French DP, Sutton S

BMJ (Clinical research ed.) Sep 2007

(DOI : 10.1136/bmj.39303.723449.55)