MRC Epidemiology Unit

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page => 16
programme => Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders of Later Life

How much might cardiovascular disease risk be reduced by intensive therapy in people with screen-detected diabetes?

Echouffo-Tcheugui JB, Sargeant LA, Prevost AT, Williams KM, Barling RS, Butler R, Fanshawe T, Kinmonth AL, Wareham NJ, Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association Dec 2008

(DOI : 10.1111/j.1464-5491.2008.02600.x)

How far can we explain the social class differential in respiratory function? A cross-sectional population study of 21,991 men and women from EPIC-Norfolk.

McFadden E, Luben R, Wareham NJ, Bingham S, Khaw KT

European Journal of Epidemiology Nov 2008

(DOI : 10.1007/s10654-009-9326-y)

Association of C-reactive protein with type 2 diabetes: prospective analysis and meta-analysis.

Lee CC, Adler AI, Sandhu MS, Sharp SJ, Forouhi NG, Erqou S, Luben R, Bingham S, Khaw KT, Wareham NJ

Diabetologia Nov 2008

(DOI : 10.1007/s00125-009-1338-3)

Free-living physical activity energy expenditure is strongly related to glucose intolerance in Cameroonian adults independently of obesity.

Assah FK, Ekelund U, Brage S, Mbanya JC, Wareham NJ

Diabetes care Nov 2008

(DOI : 10.2337/dc08-1538)

Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.

Qi Q, Wu Y, Li H, Loos RJ, Hu FB, Sun L, Lu L, Pan A, Liu C, Wu H, Chen L, Yu Z, Lin X

Diabetologia Nov 2008

(DOI : 10.1007/s00125-009-1290-2)

PPARGC1A sequence variation and cardiovascular risk-factor levels: a study of the main genetic effects and gene x environment interactions in children from the European Youth Heart Study.

Brito EC, Vimaleswaran KS, Brage S, Andersen LB, Sardinha LB, Wareham NJ, Ekelund U, Loos RJ, Franks PW

Diabetologia Nov 2008

(DOI : 10.1007/s00125-009-1269-z)

ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk.

Talmud PJ, Smart M, Presswood E, Cooper JA, Nicaud V, Drenos F, Palmen J, Marmot MG, Boekholdt SM, Wareham NJ, Khaw KT, Kumari M, Humphries SE

Arteriosclerosis, thrombosis, and vascular biology Nov 2008

(DOI : 10.1161/ATVBAHA.108.176917)

Genetic variation in LIN28B is associated with the timing of puberty.

Ong KK, Elks CE, Li S, Zhao JH, Luan J, Andersen LB, Bingham SA, Brage S, Smith GD, Ekelund U, Gillson CJ, Glaser B, Golding J, Hardy R, Khaw KT, Kuh D, Luben R, Marcus M, McGeehin MA, Ness AR, Northstone K, Ring SM, Rubin C, Sims MA, Song K, Strachan DP, Vollenweider P, Waeber G, Waterworth DM, Wong A, Deloukas P, Barroso I, Mooser V, Loos RJ, Wareham NJ

Nature genetics Oct 2008

(DOI : 10.1038/ng.382)

Prevention of diabetes and cardiovascular disease in patients with impaired glucose tolerance: rationale and design of the Nateglinide And Valsartan in Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial.

Califf RM, Boolell M, Haffner SM, Bethel M, McMurray J, Duggal A, Holman RR

American heart journal Oct 2008

(DOI : 10.1016/j.ahj.2008.05.017)

Prevalence of diagnosed and undiagnosed diabetes mellitus and its risk factors in a population-based study of Qatar.

Bener A, Zirie M, Janahi IM, Al-Hamaq AO, Musallam M, Wareham NJ

Diabetes Research and Clinical Practice Oct 2008

(DOI : 10.1016/j.diabres.2009.02.003)

Retinol-binding protein 4 and prediction of incident coronary events in healthy men and women.

Mallat Z, Simon T, Benessiano J, Clément K, Taleb S, Wareham NJ, Luben R, Khaw KT, Tedgui A, Boekholdt SM

The Journal of clinical endocrinology and metabolism Oct 2008

(DOI : 10.1210/jc.2008-0253)

Relationship between subdomains of total physical activity and mortality.

Besson H, Ekelund U, Brage S, Luben R, Bingham S, Khaw KT, Wareham NJ

Medicine and Science in Sports and Exercise Oct 2008

(DOI : 10.1249/MSS.0b013e318180bcad)

Estimation of absolute fracture risk among middle-aged and older men and women: the EPIC-Norfolk population cohort study.

Moayyeri A, Kaptoge S, Luben RN, Wareham NJ, Bingham S, Reeve J, Khaw KT

European Journal of Epidemiology Oct 2008

(DOI : 10.1007/s10654-009-9337-8)

Effect of age and sex on the relationship between different socioeconomic indices and self-reported functional health in the EPIC-Norfolk population-based study.

Myint PK, Luben RN, Surtees PG, Wainwright NW, Bingham SA, Wareham NJ, Khaw KT

Annals of Epidemiology Oct 2008

(DOI : 10.1016/j.annepidem.2009.02.003)

Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Britton JA, Khan AE, Rohrmann S, Becker N, Linseisen J, Nieters A, Kaaks R, Tjønneland A, Halkjaer J, Severinsen MT, Overvad K, Pischon T, Boeing H, Trichopoulou A, Kalapothaki V, Trichopoulos D, Mattiello A, Tagliabue G, Sacerdote C, Peeters PH, Bueno-de-Mesquita HB, Ardanaz E, Navarro C, Jakszyn P, Altzibar JM, Hallmans G, Malmer B, Berglund G, Manjer J, Allen N, Key T, Bingham S, Besson H, Ferrari P, Jenab M, Boffetta P, Vineis P, Riboli E

Haematologica Oct 2008

(DOI : 10.3324/haematol.13078)

Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses.

Souren NY, Zeegers MP, Janssen RG, Steyls A, Gielen M, Loos RJ, Beunen G, Fagard R, Stassen AP, Aerssens J, Derom C, Vlietinck R, Paulussen AD

Twin research and human genetics : the official journal of the International Society for Twin Studies Oct 2008

(DOI : 10.1375/twin.11.5.505)

Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Rana JS, Visser ME, Arsenault BJ, Després JP, Stroes ES, Kastelein JJ, Wareham NJ, Boekholdt SM, Khaw KT

International journal of cardiology Sep 2008

(DOI : 10.1016/j.ijcard.2009.03.123)

Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P

PLoS genetics Sep 2008

(DOI : 10.1371/journal.pgen.1000445)

Decrease in activity from childhood to adolescence: potential causes and consequences.

Wareham NJ, Corder KL, Van Sluijs EM

American Journal of Preventive Medicine Sep 2008

(DOI : 10.1016/j.amepre.2008.09.014)

Time spent being sedentary and weight gain in healthy adults: reverse or bidirectional causality?

Ekelund U, Brage S, Besson H, Sharp SJ, Wareham NJ

The American Journal of Clinical Nutrition Sep 2008

(DOI : 10.1093/ajcn/88.3.612)

Risk factors for first-ever stroke in the EPIC-Norfolk prospective population-based study.

Myint PK, Sinha S, Luben RN, Bingham SA, Wareham NJ, Khaw KT

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Sep 2008

(DOI : 10.1097/HJR.0b013e32830fe465)

Major depression, C-reactive protein, and incident ischemic heart disease in healthy men and women.

Surtees PG, Wainwright NW, Boekholdt SM, Luben RN, Wareham NJ, Khaw KT

Psychosomatic medicine Aug 2008

(DOI : 10.1097/PSY.0b013e318183acd5)

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S, Venkatesh R, Frayling TM, Delgado M, Neuman RJ, Zhao J, Sherva R, Glaser B, Walker M, Hitman G, McCarthy MI, Hattersley AT, Permutt MA, Wareham NJ, Deloukas P

Diabetes Aug 2008

(DOI : 10.2337/db08-0719)

Power for genetic association study of human longevity using the case-control design.

Tan Q, Zhao JH, Zhang D, Kruse TA, Christensen K

American Journal of Epidemiology Aug 2008

(DOI : 10.1093/aje/kwn205)

No association between APOE and major depressive disorder in a community sample of 17,507 adults.

Surtees PG, Wainwright NW, Bowman R, Luben RN, Wareham NJ, Khaw KT, Bingham SA

Journal of psychiatric research Aug 2008

(DOI : 10.1016/j.jpsychires.2008.12.001)

HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Arsenault BJ, Lemieux I, Després JP, Gagnon P, Wareham NJ, Stroes ES, Kastelein JJ, Khaw KT, Boekholdt SM

Atherosclerosis Aug 2008

(DOI : 10.1016/j.atherosclerosis.2009.01.044)

The effect of including quantitative heel ultrasound in models for estimation of 10-year absolute risk of fracture.

Moayyeri A, Kaptoge S, Dalzell N, Luben RN, Wareham NJ, Bingham S, Reeve J, Khaw KT

Bone Aug 2008

(DOI : 10.1016/j.bone.2009.05.001)

Blood pressure and interactions between the angiotensin polymorphism AGT M235T and sodium intake: a cross-sectional population study.

Norat T, Bowman R, Luben R, Welch A, Khaw KT, Wareham NJ, Bingham S

The American Journal of Clinical Nutrition Aug 2008

(DOI : 10.1093/ajcn/88.2.392)

Dietary energy density predicts the risk of incident type 2 diabetes: the European Prospective Investigation of Cancer (EPIC)-Norfolk Study.

Wang J, Luben R, Khaw KT, Bingham S, Wareham NJ, Forouhi NG

Diabetes care Aug 2008

(DOI : 10.2337/dc08-1085)

Genome-wide association study identifies eight loci associated with blood pressure.

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS, Subirana I, Freimer NB, Hartikainen AL, McCarthy MI, O'Reilly PF, Peltonen L, Pouta A, de Jong PE, Snieder H, van Gilst WH, Clarke R, Goel A, Hamsten A, Peden JF, Seedorf U, Syvänen AC, Tognoni G, Lakatta EG, Sanna S, Scheet P, Schlessinger D, Scuteri A, Dörr M, Ernst F, Felix SB, Homuth G, Lorbeer R, Reffelmann T, Rettig R, Völker U, Galan P, Gut IG, Hercberg S, Lathrop GM, Zelenika D, Deloukas P, Soranzo N, Williams FM, Zhai G, Salomaa V, Laakso M, Elosua R, Forouhi NG, Völzke H, Uiterwaal CS, van der Schouw YT, Numans ME, Matullo G, Navis G, Berglund G, Bingham SA, Kooner JS, Connell JM, Bandinelli S, Ferrucci L, Watkins H, Spector TD, Tuomilehto J, Altshuler D, Strachan DP, Laan M, Meneton P, Wareham NJ, Uda M, Järvelin MR, Mooser V, Melander O, Loos RJ, Elliott P, Abecasis GR, Caulfield M, Munroe PB

Nature genetics Aug 2008

(DOI : 10.1038/ng.361)

Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer--Norfolk prospective study.

Harding AH, Wareham NJ, Bingham SA, Khaw K, Luben R, Welch A, Forouhi NG

Archives of internal medicine Jul 2008

(DOI : 10.1001/archinte.168.14.1493)

Back to the future--do IGT and IFG have value as clinical entities?

Colagiuri S, Borch-Johnsen K, Wareham NJ

Diabetes Research and Clinical Practice Jul 2008

(DOI : 10.1016/j.diabres.2008.07.001)

Ghrelin receptor gene polymorphisms and body size in children and adults.

Garcia EA, Heude B, Petry CJ, Gueorguiev M, Hassan-Smith ZK, Spanou A, Ring SM, Dunger DB, Wareham NJ, Sandhu MS, Ong KK, Korbonits M

The Journal of clinical endocrinology and metabolism Jul 2008

(DOI : 10.1210/jc.2008-0366)

Assessment of physical activity in youth.

Corder KL, Ekelund U, Steele RM, Wareham NJ, Brage S

Journal of applied physiology (Bethesda, Md. : 1985) Jul 2008

(DOI : 10.1152/japplphysiol.00094.2008)

Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

Wu Y, Li H, Loos RJ, Yu Z, Ye X, Chen L, Pan A, Hu FB, Lin X

Diabetes Jul 2008

(DOI : 10.2337/db08-0047)

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Järvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN

Nature genetics Jul 2008

(DOI : 10.1038/ng.287)

Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.

Fawcett KA, Grimsey N, Loos RJ, Wheeler E, Daly A, Soos M, Semple R, Syddall H, Cooper C, Siniossoglou S, O'Rahilly S, Wareham NJ, Barroso I

Diabetes Jul 2008

(DOI : 10.2337/db08-0422)

Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000.

Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ

Diabetes Jul 2008

(DOI : 10.2337/db08-0593)

Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study.

Bingham S, Luben R, Welch A, Low YL, Khaw KT, Wareham NJ, Day N

International Journal of Epidemiology Jun 2008

(DOI : 10.1093/ije/dyn111)

Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies.

Ruchat SM, Elks CE, Loos RJ, Vohl MC, Weisnagel SJ, Rankinen T, Bouchard C, Pérusse L

Acta diabetologica Jun 2008

(DOI : 10.1007/s00592-008-0080-5)

The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals.

Kurokawa N, Young EH, Oka Y, Satoh H, Wareham NJ, Sandhu MS, Loos RJ

International Journal of Obesity Jun 2008

(DOI : 10.1038/ijo.2008.90)

Evaluation of the Framingham risk score in the European Prospective Investigation of Cancer-Norfolk cohort: does adding glycated hemoglobin improve the prediction of coronary heart disease events?

Simmons RK, Sharp SJ, Boekholdt SM, Sargeant LA, Khaw KT, Wareham NJ, Griffin SJ

Archives of internal medicine Jun 2008

(DOI : 10.1001/archinte.168.11.1209)

Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: environmental Determinants in Young people).

Van Sluijs EM, Skidmore PM, Mwanza K, Jones AP, Callaghan AM, Ekelund U, Harrison F, Harvey I, Panter J, Wareham NJ, Cassidy A, Griffin SJ

BMC Public Health Jun 2008

(DOI : 10.1186/1471-2458-8-388)

Variants in MTNR1B influence fasting glucose levels.

Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp SJ, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Järvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR

Nature genetics Jun 2008

(DOI : 10.1038/ng.290)

A simple risk score identifies individuals at high risk of developing Type 2 diabetes: a prospective cohort study.

Rahman M, Simmons RK, Harding AH, Wareham NJ, Griffin SJ

Family practice Jun 2008

(DOI : 10.1093/fampra/cmn024)

Does the association between self-rated health and mortality vary by social class?

McFadden E, Luben R, Bingham S, Wareham NJ, Kinmonth AL, Khaw KT

Social science & medicine (1982) Jun 2008

(DOI : 10.1016/j.socscimed.2008.10.012)

Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites.

Franks PW, Scheele C, Loos RJ, Nielsen AR, Finucane FM, Wahlestedt C, Pedersen BK, Wareham NJ, Timmons JA

FASEB journal : official publication of the Federation of American Societies for Experimental Biology May 2008

(DOI : 10.1096/fj.08-107086)

Common SNPs in LEP and LEPR associated with birth weight and type 2 diabetes-related metabolic risk factors in twins.

Souren NY, Paulussen AD, Steyls A, Loos RJ, Stassen AP, Gielen M, Smeets HJ, Beunen G, Fagard R, Derom C, Vlietinck R, Geraedts JP, Zeegers MP

International Journal of Obesity May 2008

(DOI : 10.1038/ijo.2008.68)

Mining gene networks with application to GAW15 Problem 1.

Zhao JH, Luan J, Baksh MF, Tan Q

BMC proceedings May 2008

(DOI : 10.1186/1753-6561-1-s1-s52)

The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals.

Vimaleswaran KS, Luan J, Andersen G, Muller YL, Wheeler E, Brito EC, O'Rahilly S, Pedersen O, Baier LJ, Knowler WC, Barroso I, Wareham NJ, Loos RJ, Franks PW

Journal of applied physiology (Bethesda, Md. : 1985) May 2008

(DOI : 10.1152/japplphysiol.90423.2008)

Use of accelerometers in a large field-based study of children: protocols, design issues, and effects on precision.

Mattocks C, Ness A, Leary S, Tilling K, Blair SN, Shield J, Deere K, Saunders J, Kirkby J, Smith GD, Wells J, Wareham NJ, Reilly J, Riddoch C

Journal of Physical Activity and Health Apr 2008

Factor VII, blood lipids and fat intake: gene-nutrient interaction and risk of coronary heart disease with the factor VII R353Q polymorphism.

Bowman R, Joosen AM, Welch AA, Luben RN, Khaw KT, Wareham NJ, Bingham SA

European Journal of Clinical Nutrition Apr 2008

(DOI : 10.1038/ejcn.2008.28)

Progress in the genetics of common obesity: size matters.

Li S, Loos RJ

Current opinion in lipidology Apr 2008

(DOI : 10.1097/MOL.0b013e3282f6a7f3)

FTO: the first gene contributing to common forms of human obesity.

Loos RJ, Bouchard C

Obesity reviews : an official journal of the International Association for the Study of Obesity Apr 2008

(DOI : 10.1111/j.1467-789X.2008.00481.x)

Whole genome-amplified DNA: insights and imputation.

Teo YY, Inouye M, Small KS, Fry AE, Potter SC, Dunstan SJ, Seielstad M, Barroso I, Wareham NJ, Rockett KA, Kwiatkowski DP, Deloukas P

Nature methods Apr 2008

(DOI : 10.1038/nmeth0408-279)

Physical activity, cardiorespiratory fitness, and the metabolic syndrome in youth.

Steele RM, Brage S, Corder KL, Wareham NJ, Ekelund U

Journal of applied physiology (Bethesda, Md. : 1985) Mar 2008

(DOI : 10.1152/japplphysiol.00072.2008)

Twin-specific intrauterine 'growth' charts based on cross-sectional birthweight data.

Gielen M, Lindsey PJ, Derom C, Loos RJ, Souren NY, Paulussen AD, Zeegers MP, Derom R, Vlietinck R, Nijhuis JG

Twin research and human genetics : the official journal of the International Society for Twin Studies Mar 2008

(DOI : 10.1375/twin.11.2.224)

Prevalence of angina in women versus men: a systematic review and meta-analysis of international variations across 31 countries.

Hemingway H, Langenberg C, Damant J, Frost C, Pyörälä K, Barrett-Connor E

Circulation Mar 2008

(DOI : 10.1161/CIRCULATIONAHA.107.720953)

Psychological distress, major depressive disorder, and risk of stroke.

Surtees PG, Wainwright NW, Luben RN, Wareham NJ, Bingham SA, Khaw KT

Neurology Mar 2008

(DOI : 10.1212/01.wnl.0000304109.18563.81)

Double-strand break DNA repair genotype predictive of later mortality and cancer incidence in a cohort of non-smokers.

Neasham D, Gallo V, Guarrera S, Dunning A, Overvad K, Tjonneland A, Clavel-Chapelon F, Linseisen JP, Malaveille C, Ferrari P, Boeing H, Benetou V, Trichopoulou A, Palli D, Crosignani P, Tumino R, Panico S, Bueno-de-Mesquita HB, Peeters PH, van Gib CH, Lund E, González CA, Martínez C, Dorronsoro M, Barricarte A, Navarro C, Quirós JR, Berglund G, Järvholm B, Khaw KT, Key TJ, Bingham S, Diaz TM, Riboli E, Matullo G, Vineis P

DNA repair Mar 2008

(DOI : 10.1016/j.dnarep.2008.08.012)

Social inequalities in self-rated health by age: cross-sectional study of 22,457 middle-aged men and women.

McFadden E, Luben R, Bingham S, Wareham NJ, Kinmonth AL, Khaw KT

BMC Public Health Mar 2008

(DOI : 10.1186/1471-2458-8-230)

Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study.

Ruchat SM, Loos RJ, Rankinen T, Vohl MC, Weisnagel SJ, Després JP, Bouchard C, Pérusse L

Diabetic medicine : a journal of the British Diabetic Association Feb 2008

(DOI : 10.1111/j.1464-5491.2008.02396.x)

LDL-cholesterol concentrations: a genome-wide association study.

Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X, Johnson T, Ashford S, Inouye M, Luben R, Sims M, Hadley D, McArdle W, Barter P, Kesaniemi YA, Mahley RW, McPherson R, Grundy SM, Bingham SA, Khaw KT, Loos RJ, Waeber G, Barroso I, Strachan DP, Deloukas P, Vollenweider P, Wareham NJ, Mooser V

Lancet (London, England) Feb 2008

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Depression and ischemic heart disease mortality: evidence from the EPIC-Norfolk United Kingdom prospective cohort study.

Surtees PG, Wainwright NW, Luben RN, Wareham NJ, Bingham SA, Khaw KT

The American journal of psychiatry Feb 2008

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Habitual energy expenditure modifies the association between NOS3 gene polymorphisms and blood pressure.

Vimaleswaran KS, Franks PW, Barroso I, Brage S, Ekelund U, Wareham NJ, Loos RJ

American journal of hypertension Feb 2008

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The association of intensity and overall level of physical activity energy expenditure with a marker of insulin resistance.

Assah FK, Brage S, Ekelund U, Wareham NJ

Diabetologia Feb 2008

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Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the European Prospective into Cancer-Norfolk cohort study.

Ward H, Chapelais G, Kuhnle GG, Luben R, Khaw KT, Bingham S, European Prospective into Cancer-Norfolk cohort

Breast cancer research : BCR Jan 2008

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An ensemble learning approach jointly modeling main and interaction effects in genetic association studies.

Zhang Z, Zhang S, Wong MY, Wareham NJ, Sha Q

Genetic epidemiology Jan 2008

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Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort.

McFadden E, Luben R, Wareham NJ, Bingham S, Khaw KT

European Journal of Epidemiology Jan 2008

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The evaluation of the diet/disease relation in the EPIC study: considerations for the calibration and the disease models.

Ferrari P, Day NE, Boshuizen HC, Roddam A, Hoffmann K, Thiebaut A, Pera G, Overvad K, Lund E, Trichopoulou A, Tumino R, Gullberg B, Norat T, Slimani N, Kaaks R, Riboli E

International Journal of Epidemiology Jan 2008

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Plasma vitamin C concentrations predict risk of incident stroke over 10 y in 20 649 participants of the European Prospective Investigation into Cancer Norfolk prospective population study.

Myint PK, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT

The American Journal of Clinical Nutrition Jan 2008

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Efficacy of a theory-based behavioural intervention to increase physical activity in an at-risk group in primary care (ProActive UK): a randomised trial.

Kinmonth AL, Wareham NJ, Hardeman W, Sutton S, Prevost AT, Fanshawe T, Williams KM, Ekelund U, Spiegelhalter D, Griffin SJ

Lancet (London, England) Jan 2008

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Physical activity and mammographic breast density in the EPIC-Norfolk cohort study.

Peters TM, Ekelund U, Leitzmann M, Easton D, Warren R, Luben R, Bingham S, Khaw KT, Wareham NJ

American Journal of Epidemiology Dec 2007

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Mendelian randomisation studies of type 2 diabetes: future prospects.

Sandhu MS, Debenham SL, Barroso I, Loos RJ

Diabetologia Dec 2007

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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

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Nature genetics Dec 2007

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Energy intake at breakfast and weight change: prospective study of 6,764 middle-aged men and women.

Purslow LR, Sandhu MS, Forouhi N, Young EH, Luben RN, Welch AA, Khaw KT, Bingham SA, Wareham NJ

American Journal of Epidemiology Dec 2007

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Physical health-related quality of life predicts stroke in the EPIC-Norfolk.

Myint PK, Surtees PG, Wainwright NW, Luben RN, Welch AA, Bingham SA, Wareham NJ, Khaw KT

Neurology Dec 2007

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Body fat distribution and risk of coronary heart disease in men and women in the European Prospective Investigation Into Cancer and Nutrition in Norfolk cohort: a population-based prospective study.

Canoy D, Boekholdt SM, Wareham N, Luben R, Welch A, Bingham S, Buchan I, Day N, Khaw KT

Circulation Dec 2007

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Association between age at menarche and risk of diabetes in adults: results from the EPIC-Norfolk cohort study.

Lakshman R, Forouhi N, Luben R, Bingham S, Khaw K, Wareham NJ, Ong KK

Diabetologia Dec 2007

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Cross-sectional association between fish consumption and albuminuria: the European Prospective Investigation of Cancer-Norfolk Study.

Lee CT, Adler AI, Forouhi NG, Luben R, Welch A, Khaw KT, Bingham S, Wareham NJ

American journal of kidney diseases : the official journal of the National Kidney Foundation Dec 2007

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Comparison of two methods to assess PAEE during six activities in children.

Corder KL, Brage S, Mattocks C, Ness A, Riddoch C, Wareham NJ, Ekelund U

Medicine and Science in Sports and Exercise Nov 2007

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Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study.

Khaw KT, Dowsett M, Folkerd E, Bingham S, Wareham NJ, Luben R, Welch A, Day N

Circulation Nov 2007

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Genome-wide association analysis identifies 20 loci that influence adult height.

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JR, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CN, Morris AD, Ouwehand WH, Zhao JH, Li S, Loos RJ, Barroso I, Deloukas P, Sandhu MS, Wheeler E, Soranzo N, Inouye M, Wareham NJ, Caulfield M, Munroe PB, Hattersley AT, McCarthy MI, Frayling TM

Nature genetics Nov 2007

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The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.

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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Nov 2007

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Common variants near MC4R are associated with fat mass, weight and risk of obesity.

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