MRC Epidemiology Unit

 

Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk

Wareham NJ, Bingham SA, Day NE, Dunning AM, Khaw KT, Low YL, Luben RN, Mulligan AA, Welch AA, Taylor JI, Grace PB

Nutrition and cancer. Nov 2009

(DOI : 10.1207/s15327914nc5601_5)

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Association of ESR1 gene tagging SNPs with breast cancer risk.

Dunning AM, Healey CS, Baynes C, Maia AT, Scollen S, Vega A, Rodríguez R, Barbosa-Morais NL, Ponder BA, SEARCH SEARCH, Low YL, Bingham S, EPIC EPIC, Haiman CA, Le Marchand L, MEC MEC, Broeks A, Schmidt MK, ABCS ABCS, Hopper J, Southey M, ABCFS ABCFS, Beckmann MW, Fasching PA, BBCC BBCC, Peto J, Johnson N, BBCS BBCS, Bojesen SE, Nordestgaard B, CGPS CGPS, Milne RL, Benitez J, CNIO-BCS CNIO-BCS, Hamann U, Ko Y, GENICA GENICA, Schmutzler RK, Burwinkel B, GC-HBOC GC-HBOC, Schürmann P, Dörk T, HABCS HABCS, Heikkinen T, Nevanlinna H, HEBCS HEBCS, Lindblom A, Margolin S, KARBAC KARBAC, Mannermaa A, Kosma VM, KBCS KBCS, Chen X, Spurdle A, kConFab and the AOCS Management Group, Change-Claude J, Flesch-Janys D, MARIE MARIE, Couch FJ, Olson JE, for MCBCS for MCBCS, Severi G, Baglietto L, MCCS MCCS, Børresen-Dale AL, Kristensen V, NBCS NBCS, Hunter DJ, Hankinson SE, NHS NHS, Devilee P, Vreeswijk M, ORIGO ORIGO, Lissowska J, Brinton L, PBCS PBCS, Liu J, Hall P, SASBAC SASBAC, Kang D, Yoo KY, SEBCS SEBCS, Shen CY, Yu JC, TWBCS TWBCS, Anton-Culver H, Ziogoas A, UCIBCS UCIBCS, Sigurdson A, Struewing J, USRTS USRTS, Easton DF, García-Closas M, Humphreys MK, Morrison J, Pharoah PD, Pooley KA, Chenevix-Trench G, BCAC BCAC

Human Molecular Genetics. Jan 2009

(DOI : 10.1093/hmg/ddn429)

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Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study.

Bingham S, Luben R, Welch A, Low YL, Khaw KT, Wareham NJ, Day N

International Journal of Epidemiology. Jun 2008

(DOI : 10.1093/ije/dyn111)

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Extraction and quantification of phytoestrogens in foods using automated solid-phase extraction and LC/MS/MS.

Kuhnle GG, Dell'aquila C, Low YL, Kussmaul M, Bingham SA

Analytical chemistry. Nov 2007

(DOI : 10.1021/ac701732r)

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Phytoestrogen exposure is associated with circulating sex hormone levels in postmenopausal women and interact with ESR1 and NR1I2 gene variants.

Low YL, Dunning AM, Dowsett M, Folkerd E, Doody D, Taylor J, Bhaniani A, Luben R, Khaw KT, Wareham NJ, Bingham SA

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. May 2007

(DOI : 10.1158/1055-9965.EPI-06-0899)

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Genome-wide association study identifies novel breast cancer susceptibility loci.

Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham NJ, Ahmed S, Healey CS, Bowman R, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, Fletcher O, Johnson N, Seal S, Stratton MR, Rahman N, Chenevix-Trench G, Bojesen SE, Nordestgaard BG, Axelsson CK, García-Closas M, Brinton L, Chanock S, Lissowska J, Peplonska B, Nevanlinna H, Fagerholm R, Eerola H, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P, Wedren S, Liu J, Low YL, Bogdanova N, Schürmann P, Dörk T, Tollenaar RA, Jacobi CE, Devilee P, Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J, Cox A, Brock IW, MacPherson G, Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H, van den Ouweland A, Uitterlinden A, Rivadeneira F, Milne RL, Ribas G, González-Neira A, Benitez J, Hopper JL, McCredie M, Southey M, Giles GG, Schroen C, Justenhoven C, Brauch H, Hamann U, Ko YD, Spurdle AB, Beesley J, Chen X, Mannermaa A, Kosma VM, Kataja V, Hartikainen J, Day NE, Cox DR, Ponder BA

Nature. Feb 2007

(DOI : 10.1038/nature05887)

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Implications of gene-environment interaction in studies of gene variants in breast cancer: an example of dietary isoflavones and the D356N polymorphism in the sex hormone-binding globulin gene.

Low YL, Dunning AM, Dowsett M, Luben RN, Khaw KT, Wareham NJ, Bingham SA

Cancer research. Sep 2006

(DOI : 10.1158/0008-5472.CAN-06-2432)

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Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.

Low YL, Taylor JI, Grace PB, Dowsett M, Folkerd E, Doody D, Dunning AM, Scollen S, Mulligan AA, Welch AA, Luben RN, Khaw KT, Day NE, Wareham NJ, Bingham SA

The Journal of nutrition. Oct 2005

(DOI : 10.1093/jn/135.11.2680)

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Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions.

Low YL, Taylor JI, Grace PB, Dowsett M, Scollen S, Dunning AM, Mulligan AA, Welch AA, Luben RN, Khaw KT, Day NE, Wareham NJ, Bingham SA

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Jan 2005

(DOI : 14/1/213)

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Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk.

Grace PB, Taylor JI, Low YL, Luben RN, Mulligan AA, Botting NP, Dowsett M, Welch AA, Khaw KT, Wareham NJ, Day NE, Bingham SA

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. May 2004

(DOI : 13/5/698)

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