MRC Epidemiology Unit

 

Trends in hospitalization for cardio-renal disease and mortality in people with type 1 diabetes in England, 2009-2019.

Holman N, Young B, Gregg EW, Wareham N, Sharp S, Khunti K, Sattar N, Valabhji J

Diabetes, obesity & metabolism. Aug 2024

(DOI : 10.1111/dom.15783)

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Prediabetes, participation in the English National Health Service Diabetes Prevention Programme, and associations with COVID-19-related mortality: A whole population study.

Barron E, Sharp SJ, Khunti K, Bakhai C, Wareham NJ, Valabhji J

Diabetes Research and Clinical Practice. May 2024

(DOI : 10.1016/j.diabres.2024.111692)

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Use of Real-World Data in Population Science to Improve the Prevention and Care of Diabetes-Related Outcomes.

Gregg EW, Patorno E, Karter AJ, Mehta R, Huang ES, White M, Patel CJ, McElvaine AT, Cefalu WT, Selby J, Riddle MC, Khunti K

Diabetes care. Jun 2023

(DOI : 10.2337/dc22-1438)

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Socioeconomic inequalities of Long COVID: a retrospective population-based cohort study in the United Kingdom.

Shabnam S, Razieh C, Dambha-Miller H, Yates T, Gillies C, Chudasama YV, Pareek M, Banerjee A, Kawachi I, Lacey B, Morris EJ, White M, Zaccardi F, Khunti K, Islam N

Journal of the Royal Society of Medicine. May 2023

(DOI : 10.1177/01410768231168377)

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Ethnic disparities in COVID-19 outcomes: a multinational cohort study of 20 million individuals from England and Canada.

Zaccardi F, Tan PS, Shah BR, Everett K, Clift AK, Patone M, Saatci D, Coupland C, Griffin SJ, Khunti K, Dambha-Miller H, Hippisley-Cox J

BMC Public Health. Feb 2023

(DOI : 10.1186/s12889-023-15223-8)

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Effectiveness of digital and remote provision of the Healthier You: NHS Diabetes Prevention Programme during the COVID-19 pandemic.

Barron E, Bradley D, Safazadeh S, McGough B, Bakhai C, Young B, Khunti K, Murray E, Wareham N, Jebb S, Valabhji J

Diabetic medicine : a journal of the British Diabetic Association. Dec 2022

(DOI : 10.1111/dme.15028)

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Ethnicity and risks of severe COVID-19 outcomes associated with glucose-lowering medications: a cohort study.

Zaccardi F, Tan PS, Coupland C, Shah BR, Clift AK, Saatci D, Patone M, Griffin SJ, Dambha-Miller H, Khunti K, Hippisley-Cox J

Diabetes, obesity & metabolism. Aug 2022

(DOI : 10.1111/dom.14872)

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Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England.

Saatci D, Ranger TA, Garriga C, Clift AK, Zaccardi F, Tan PS, Patone M, Coupland C, Harnden A, Griffin SJ, Khunti K, Dambha-Miller H, Hippisley-Cox J

JAMA pediatrics. Jun 2022

(DOI : 10.1001/jamapediatrics.2021.1685)

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Associations between reductions in routine care delivery and non-COVID-19-related mortality in people with diabetes in England during the COVID-19 pandemic: a population-based parallel cohort study.

Valabhji J, Barron E, Gorton T, Bakhai C, Kar P, Young B, Khunti K, Holman N, Sattar N, Wareham NJ

The lancet. Diabetes & endocrinology. May 2022

(DOI : 10.1016/S2213-8587(22)00131-0)

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Associations between socioeconomic position and young people's physical activity and sedentary behaviour in the UK: a scoping review.

Pearson N, Griffiths P, van Sluijs E, Atkin AJ, Khunti K, Sherar LB

BMJ Open. May 2022

(DOI : 10.1136/bmjopen-2021-051736)

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Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length.

Dempsey PC, Musicha C, Rowlands AV, Davies M, Khunti K, Razieh C, Timmins I, Zaccardi F, Codd V, Nelson CP, Yates T, Samani NJ

Communications biology. Apr 2022

(DOI : 10.1038/s42003-022-03323-x)

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Behavioural interventions to promote physical activity in a multiethnic population at high risk of diabetes: PROPELS three-arm RCT.

Khunti K, Griffin S, Brennan A, Dallosso H, Davies M, Eborall H, Edwardson C, Gray L, Hardeman W, Heathcote L, Henson J, Morton K, Pollard D, Sharp S, Sutton S, Troughton J, Yates T

Health technology assessment (Winchester, England). Jan 2022

(DOI : 10.3310/hta25770)

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Effects of covid-19 pandemic on life expectancy and premature mortality in 2020: time series analysis in 37 countries.

Islam N, Jdanov DA, Shkolnikov VM, Khunti K, Kawachi I, White M, Lewington S, Lacey B

BMJ (Clinical research ed.). Nov 2021

(DOI : 10.1136/bmj-2021-066768)

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Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Hippisley-Cox J, Patone M, Mei XW, Saatci D, Dixon S, Khunti K, Zaccardi F, Watkinson P, Shankar-Hari M, Doidge J, Harrison DA, Griffin SJ, Sheikh A, Coupland CAC

BMJ (Clinical research ed.). Aug 2021

(DOI : 10.1136/bmj.n1931)

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Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries.

Islam N, Shkolnikov VM, Acosta RJ, Klimkin I, Kawachi I, Irizarry RA, Alicandro G, Khunti K, Yates T, Jdanov DA, White M, Lewington S, Lacey B

BMJ (Clinical research ed.). May 2021

(DOI : 10.1136/bmj.n1137)

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Quantifying the association between ethnicity and COVID-19 mortality: a national cohort study protocol.

Dambha-Miller H, Tan PS, Saatci D, Clift AK, Zaccardi F, Coupland C, Locufier P, Davies F, Khunti K, Griffin SJ, Hippisley-Cox J

BMJ Open. Apr 2021

(DOI : 10.1136/bmjopen-2020-045286)

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Promoting physical activity in a multi-ethnic population at high risk of diabetes: the 48-month PROPELS randomised controlled trial.

Khunti K, Griffin S, Brennan A, Dallosso H, Davies MJ, Eborall HC, Edwardson CL, Gray LJ, Hardeman W, Heathcote L, Henson J, Pollard D, Sharp SJ, Sutton S, Troughton J, Yates T

BMC medicine. Mar 2021

(DOI : 10.1186/s12916-021-01997-4)

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Vitamin D and covid-19.

Vimaleswaran KS, Forouhi NG, Khunti K

BMJ (Clinical research ed.). Mar 2021

(DOI : 10.1136/bmj.n544)

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Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England.

Khunti K, Knighton P, Zaccardi F, Bakhai C, Barron E, Holman N, Kar P, Meace C, Sattar N, Sharp S, Wareham NJ, Weaver A, Woch E, Young B, Valabhji J

The lancet. Diabetes & endocrinology. Nov 2020

(DOI : 10.1016/S2213-8587(21)00050-4)

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Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.

Chudasama YV, Zaccardi F, Gillies CL, Razieh C, Yates T, Kloecker DE, Rowlands AV, Davies MJ, Islam N, Seidu S, Forouhi NG, Khunti K

BMC infectious diseases. Sep 2020

(DOI : 10.1186/s12879-021-06600-y)

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Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial.

Strelitz J, Sharp SJ, Khunti K, Vos RC, Rutten GEHM, Webb DR, Witte DR, Sandbaek A, Wareham NJ, Griffin SJ

Diabetes, obesity & metabolism. Jul 2020

(DOI : 10.1111/dom.14278)

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Experience of point-of-care HbA1c testing in the English National Health Service Diabetes Prevention Programme: an observational study.

Barron E, Misra S, English E, John WG, Sampson M, Bachmann MO, Barth J, Oliver N, Alberti KGMM, Bakhai C, O'Neill S, Young B, Wareham NJ, Khunti K, Jebb S, Smith J, Valabhji J

BMJ open diabetes research & care. Jun 2020

(DOI : 10.1136/bmjdrc-2020-001703)

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Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes: the ADDITION-Europe trial.

Dalsgaard EM, Sandbaek A, Griffin SJ, Rutten GEHM, Khunti K, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, Witte DR

Diabetic medicine : a journal of the British Diabetic Association. Jun 2020

(DOI : 10.1111/dme.14342)

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Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study.

Barron E, Bakhai C, Kar P, Weaver A, Bradley D, Ismail H, Knighton P, Holman N, Khunti K, Sattar N, Wareham NJ, Young B, Valabhji J

The lancet. Diabetes & endocrinology. May 2020

(DOI : 10.1016/S2213-8587(20)30272-2)

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Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study.

Holman N, Knighton P, Kar P, O'Keefe J, Curley M, Weaver A, Barron E, Bakhai C, Khunti K, Wareham NJ, Sattar N, Young B, Valabhji J

The lancet. Diabetes & endocrinology. May 2020

(DOI : 10.1016/S2213-8587(20)30271-0)

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Early Outcomes From the English National Health Service Diabetes Prevention Programme.

Valabhji J, Barron E, Bradley D, Bakhai C, Fagg J, O'Neill S, Young B, Wareham N, Khunti K, Jebb S, Smith J

Diabetes care. Jul 2019

(DOI : 10.2337/dc19-1425)

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Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial.

Griffin SJ, Rutten GEHM, Khunti K, Witte DR, Lauritzen T, Sharp SJ, Dalsgaard EM, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, Sandbæk A

The lancet. Diabetes & endocrinology. Nov 2018

(DOI : 10.1016/S2213-8587(19)30349-3)

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Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5-year and longer-term modelled outcomes of the ADDITION-Leicester study.

Webb D, Dales J, Zaccardi F, Hill S, Moore C, Farooqi A, Griffin SJ, Davies M, Khunti K

Diabetes/metabolism research and reviews. Jul 2018

(DOI : 10.1002/dmrr.3111)

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Metformin in non-diabetic hyperglycaemia: the GLINT feasibility RCT.

Griffin SJ, Bethel MA, Holman RR, Khunti K, Wareham N, Brierley G, Davies M, Dymond A, Eichenberger R, Evans P, Gray A, Greaves C, Harrington K, Hitman G, Irving G, Lessels S, Millward A, Petrie JR, Rutter M, Sampson M, Sattar N, Sharp S

Health technology assessment (Winchester, England). Apr 2018

(DOI : 10.3310/hta22180)

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Differences in objectively measured physical activity and sedentary behaviour between white Europeans and south Asians recruited from primary care: cross-sectional analysis of the PROPELS trial.

Biddle GJH, Edwardson CL, Rowlands AV, Davies MJ, Bodicoat DH, Hardeman W, Eborall H, Sutton S, Griffin SJ, Khunti K, Yates T

BMC Public Health. Mar 2018

(DOI : 10.1186/s12889-018-6341-5)

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A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study.

Simmons RK, Borch-Johnsen K, Lauritzen T, Rutten GE, Sandbæk A, van den Donk M, Black JA, Tao L, Wilson EC, Davies MJ, Khunti K, Sharp SJ, Wareham NJ, Griffin SJ

Health technology assessment (Winchester, England). Sep 2016

(DOI : 10.3310/hta20640)

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Cardiovascular risk factors and incident albuminuria in screen-detected type 2 diabetes.

Webb DR, Zaccardi F, Davies MJ, Griffin SJ, Wareham NJ, Simmons RK, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Khunti K

Diabetes/metabolism research and reviews. Aug 2016

(DOI : 10.1002/dmrr.2877)

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A Text-Messaging and Pedometer Program to Promote Physical Activity in People at High Risk of Type 2 Diabetes: The Development of the PROPELS Follow-On Support Program.

Morton KL, Sutton S, Hardeman W, Troughton J, Yates T, Griffin SJ, Davies M, Khunti K, Eborall H

JMIR mHealth and uHealth. Aug 2015

(DOI : 10.2196/mhealth.5026)

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PRomotion Of Physical activity through structured Education with differing Levels of ongoing Support for people at high risk of type 2 diabetes (PROPELS): study protocol for a randomized controlled trial.

Yates T, Griffin S, Bodicoat DH, Brierly G, Dallosso H, Davies MJ, Eborall H, Edwardson C, Gillett M, Gray L, Hardeman W, Hill S, Morton KL, Sutton S, Troughton J, Khunti K

Trials. Mar 2015

(DOI : 10.1186/s13063-015-0813-z)

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Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial.

Tao L, Wilson EC, Wareham NJ, Sandbaek A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

Diabetic medicine : a journal of the British Diabetic Association. Feb 2015

(DOI : 10.1111/dme.12711)

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Medication burden in the first 5 years following diagnosis of type 2 diabetes: findings from the ADDITION-UK trial cohort.

Black JA, Simmons RK, Boothby CE, Davies MJ, Webb D, Khunti K, Long GH, Griffin SJ

BMJ open diabetes research & care. Dec 2014

(DOI : 10.1136/bmjdrc-2014-000075)

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Early Detection and Treatment of Type 2 Diabetes Reduce Cardiovascular Morbidity and Mortality: A Simulation of the Results of the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen-Detected Diabetes in Primary Care (ADDITION-Europe).

Herman WH, Ye W, Griffin SJ, Simmons RK, Davies MJ, Khunti K, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Brown MB, Wareham NJ

Diabetes care. Oct 2014

(DOI : 10.2337/dc14-2459)

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Effect of early multifactorial therapy compared with routine care on microvascular outcomes at 5 years in people with screen-detected diabetes: a randomized controlled trial: the ADDITION-Europe Study.

Sandbæk A, Griffin SJ, Sharp SJ, Simmons RK, Borch-Johnsen K, Rutten GE, van den Donk M, Wareham NJ, Lauritzen T, Davies MJ, Khunti K

Diabetes care. May 2014

(DOI : 10.2337/dc13-1544)

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Change in cardiovascular risk factors following early diagnosis of type 2 diabetes: a cohort analysis of a cluster-randomised trial.

Black JA, Sharp SJ, Wareham NJ, Sandbæk A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

The British journal of general practice : the journal of the Royal College of General Practitioners. Apr 2014

(DOI : 10.3399/bjgp14X677833)

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Does early intensive multifactorial therapy reduce modelled cardiovascular risk in individuals with screen-detected diabetes? Results from the ADDITION-Europe cluster randomized trial.

Black JA, Sharp SJ, Wareham NJ, Sandbaek A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

Diabetic medicine : a journal of the British Diabetic Association. Sep 2013

(DOI : 10.1111/dme.12410)

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Diabetes-specific quality of life but not health status is independently associated with glycaemic control among patients with type 2 diabetes: a cross-sectional analysis of the ADDITION-Europe trial cohort.

Kuznetsov L, Griffin SJ, Davies MJ, Lauritzen T, Khunti K, Rutten GE, Simmons RK

Diabetes Research and Clinical Practice. Jun 2013

(DOI : 10.1016/j.diabres.2013.12.029)

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Effect of early intensive multifactorial therapy compared with routine care on self-reported health status, general well-being, diabetes-specific quality of life and treatment satisfaction in screen-detected type 2 diabetes mellitus patients (ADDITION-Europe): a cluster-randomised trial.

van den Donk M, Griffin SJ, Stellato RK, Simmons RK, Sandbæk A, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Wareham NJ, Rutten GE

Diabetologia. Apr 2013

(DOI : 10.1007/s00125-013-3011-0)

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Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial.

Simmons RK, Sharp SJ, Sandbæk A, Borch-Johnsen K, Davies MJ, Khunti K, Lauritzen T, Rutten GE, van den Donk M, Wareham NJ, Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association. Jul 2012

(DOI : 10.1111/j.1464-5491.2012.03759.x)

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Validity of self-assessed waist circumference in a multi-ethnic UK population.

Khunti K, Taub N, Webb D, Srinivasan B, Stockman J, Griffin SJ, Simmons RK, Davies MJ

Diabetic medicine : a journal of the British Diabetic Association. Oct 2011

(DOI : 10.1111/j.1464-5491.2011.03478.x)

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Intensive multifactorial intervention improves modelled coronary heart disease risk in screen-detected Type 2 diabetes mellitus: a cluster randomized controlled trial.

Webb DR, Khunti K, Gray LJ, Srinivasan BT, Farooqi A, Wareham NJ, Griffin SC, Davies MJ

Diabetic medicine : a journal of the British Diabetic Association. Sep 2011

(DOI : 10.1111/j.1464-5491.2011.03441.x)

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Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial.

Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, Lauritzen T

Lancet (London, England). Jun 2011

(DOI : 10.1016/S0140-6736(11)60698-3)

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Screening for type 2 diabetes. Lessons from the ADDITION-Europe study.

van den Donk M, Sandbaek A, Borch-Johnsen K, Lauritzen T, Simmons RK, Wareham NJ, Griffin SJ, Davies MJ, Khunti K, Rutten GE

Diabetic medicine : a journal of the British Diabetic Association. Jun 2011

(DOI : 10.1111/j.1464-5491.2011.03365.x)

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Screening for diabetes using an oral glucose tolerance test within a western multi-ethnic population identifies modifiable cardiovascular risk: the ADDITION-Leicester study.

Webb DR, Gray LJ, Khunti K, Srinivasan B, Taub N, Campbell S, Barnett J, Farooqi A, Echouffo-Tcheugui JB, Griffin SJ, Wareham NJ, Davies MJ

Diabetologia. Oct 2010

(DOI : 10.1007/s00125-011-2189-2)

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Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening.

Webb DR, Khunti K, Srinivasan B, Gray LJ, Taub N, Campbell S, Barnett J, Henson J, Hiles S, Farooqi A, Griffin SJ, Wareham NJ, Davies MJ

Trials. Nov 2009

(DOI : 10.1186/1745-6215-11-16)

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Stepwise screening for diabetes identifies people with high but modifiable coronary heart disease risk. The ADDITION study.

Sandbaek A, Griffin SJ, Rutten G, Davies M, Stolk R, Khunti K, Borch-Johnsen K, Wareham NJ, Lauritzen T

Diabetologia. Oct 2007

(DOI : 10.1007/s00125-008-1013-0)

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