MRC Epidemiology Unit

 

Physical Activity Volume, Intensity and Incident Cardiovascular Disease.

Dempsey PC, Rowlands AV, Strain T, Zaccardi F, Dawkins N, Razieh C, Davies MJ, Khunti KK, Edwardson CL, Wijndaele K, Brage S, Yates T

European heart journal. Oct 2022

(DOI : 10.1093/eurheartj/ehac613)

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Promoting physical activity in a multi-ethnic population at high risk of diabetes: the 48-month PROPELS randomised controlled trial.

Khunti K, Griffin S, Brennan A, Dallosso H, Davies MJ, Eborall HC, Edwardson CL, Gray LJ, Hardeman W, Heathcote L, Henson J, Pollard D, Sharp SJ, Sutton S, Troughton J, Yates T

BMC medicine. Mar 2021

(DOI : 10.1186/s12916-021-01997-4)

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Patterns of multimorbidity and risk of severe SARS-CoV-2 infection: an observational study in the U.K.

Chudasama YV, Zaccardi F, Gillies CL, Razieh C, Yates T, Kloecker DE, Rowlands AV, Davies MJ, Islam N, Seidu S, Forouhi NG, Khunti K

BMC infectious diseases. Sep 2020

(DOI : 10.1186/s12879-021-06600-y)

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Patient-reported outcomes after 10-year follow-up of intensive, multifactorial treatment in individuals with screen-detected type 2 diabetes: the ADDITION-Europe trial.

Dalsgaard EM, Sandbaek A, Griffin SJ, Rutten GEHM, Khunti K, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, Witte DR

Diabetic medicine : a journal of the British Diabetic Association. Jun 2020

(DOI : 10.1111/dme.14342)

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The Lancet Commission on diabetes: using data to transform diabetes care and patient lives.

Chan JCN, Lim LL, Wareham NJ, Shaw JE, Orchard TJ, Zhang P, Lau ESH, Eliasson B, Kong APS, Ezzati M, Aguilar-Salinas CA, McGill M, Levitt NS, Ning G, So WY, Adams J, Bracco P, Forouhi NG, Gregory GA, Guo J, Hua X, Klatman EL, Magliano DJ, Ng BP, Ogilvie D, Panter J, Pavkov M, Shao H, Unwin N, White M, Wou C, Ma RCW, Schmidt MI, Ramachandran A, Seino Y, Bennett PH, Oldenburg B, Gagliardino JJ, Luk AOY, Clarke PM, Ogle GD, Davies MJ, Holman RR, Gregg EW

Lancet (London, England). Nov 2019

(DOI : 10.1016/S0140-6736(20)32374-6)

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Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial.

Griffin SJ, Rutten GEHM, Khunti K, Witte DR, Lauritzen T, Sharp SJ, Dalsgaard EM, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, Sandbæk A

The lancet. Diabetes & endocrinology. Nov 2018

(DOI : 10.1016/S2213-8587(19)30349-3)

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Differences in objectively measured physical activity and sedentary behaviour between white Europeans and south Asians recruited from primary care: cross-sectional analysis of the PROPELS trial.

Biddle GJH, Edwardson CL, Rowlands AV, Davies MJ, Bodicoat DH, Hardeman W, Eborall H, Sutton S, Griffin SJ, Khunti K, Yates T

BMC Public Health. Mar 2018

(DOI : 10.1186/s12889-018-6341-5)

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A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study.

Simmons RK, Borch-Johnsen K, Lauritzen T, Rutten GE, Sandbæk A, van den Donk M, Black JA, Tao L, Wilson EC, Davies MJ, Khunti K, Sharp SJ, Wareham NJ, Griffin SJ

Health technology assessment (Winchester, England). Sep 2016

(DOI : 10.3310/hta20640)

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Cardiovascular risk factors and incident albuminuria in screen-detected type 2 diabetes.

Webb DR, Zaccardi F, Davies MJ, Griffin SJ, Wareham NJ, Simmons RK, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Khunti K

Diabetes/metabolism research and reviews. Aug 2016

(DOI : 10.1002/dmrr.2877)

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PRomotion Of Physical activity through structured Education with differing Levels of ongoing Support for people at high risk of type 2 diabetes (PROPELS): study protocol for a randomized controlled trial.

Yates T, Griffin S, Bodicoat DH, Brierly G, Dallosso H, Davies MJ, Eborall H, Edwardson C, Gillett M, Gray L, Hardeman W, Hill S, Morton KL, Sutton S, Troughton J, Khunti K

Trials. Mar 2015

(DOI : 10.1186/s13063-015-0813-z)

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Cost-effectiveness of intensive multifactorial treatment compared with routine care for individuals with screen-detected Type 2 diabetes: analysis of the ADDITION-UK cluster-randomized controlled trial.

Tao L, Wilson EC, Wareham NJ, Sandbaek A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

Diabetic medicine : a journal of the British Diabetic Association. Feb 2015

(DOI : 10.1111/dme.12711)

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Medication burden in the first 5 years following diagnosis of type 2 diabetes: findings from the ADDITION-UK trial cohort.

Black JA, Simmons RK, Boothby CE, Davies MJ, Webb D, Khunti K, Long GH, Griffin SJ

BMJ open diabetes research & care. Dec 2014

(DOI : 10.1136/bmjdrc-2014-000075)

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Early Detection and Treatment of Type 2 Diabetes Reduce Cardiovascular Morbidity and Mortality: A Simulation of the Results of the Anglo-Danish-Dutch Study of Intensive Treatment in People With Screen-Detected Diabetes in Primary Care (ADDITION-Europe).

Herman WH, Ye W, Griffin SJ, Simmons RK, Davies MJ, Khunti K, Rutten GE, Sandbaek A, Lauritzen T, Borch-Johnsen K, Brown MB, Wareham NJ

Diabetes care. Oct 2014

(DOI : 10.2337/dc14-2459)

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Effect of early multifactorial therapy compared with routine care on microvascular outcomes at 5 years in people with screen-detected diabetes: a randomized controlled trial: the ADDITION-Europe Study.

Sandbæk A, Griffin SJ, Sharp SJ, Simmons RK, Borch-Johnsen K, Rutten GE, van den Donk M, Wareham NJ, Lauritzen T, Davies MJ, Khunti K

Diabetes care. May 2014

(DOI : 10.2337/dc13-1544)

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Change in cardiovascular risk factors following early diagnosis of type 2 diabetes: a cohort analysis of a cluster-randomised trial.

Black JA, Sharp SJ, Wareham NJ, Sandbæk A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

The British journal of general practice : the journal of the Royal College of General Practitioners. Apr 2014

(DOI : 10.3399/bjgp14X677833)

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Does early intensive multifactorial therapy reduce modelled cardiovascular risk in individuals with screen-detected diabetes? Results from the ADDITION-Europe cluster randomized trial.

Black JA, Sharp SJ, Wareham NJ, Sandbaek A, Rutten GE, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Griffin SJ, Simmons RK

Diabetic medicine : a journal of the British Diabetic Association. Sep 2013

(DOI : 10.1111/dme.12410)

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Diabetes-specific quality of life but not health status is independently associated with glycaemic control among patients with type 2 diabetes: a cross-sectional analysis of the ADDITION-Europe trial cohort.

Kuznetsov L, Griffin SJ, Davies MJ, Lauritzen T, Khunti K, Rutten GE, Simmons RK

Diabetes Research and Clinical Practice. Jun 2013

(DOI : 10.1016/j.diabres.2013.12.029)

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Effect of early intensive multifactorial therapy compared with routine care on self-reported health status, general well-being, diabetes-specific quality of life and treatment satisfaction in screen-detected type 2 diabetes mellitus patients (ADDITION-Europe): a cluster-randomised trial.

van den Donk M, Griffin SJ, Stellato RK, Simmons RK, Sandbæk A, Lauritzen T, Khunti K, Davies MJ, Borch-Johnsen K, Wareham NJ, Rutten GE

Diabetologia. Apr 2013

(DOI : 10.1007/s00125-013-3011-0)

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Does early intensive multifactorial treatment reduce total cardiovascular burden in individuals with screen-detected diabetes? Findings from the ADDITION-Europe cluster-randomized trial.

Simmons RK, Sharp SJ, Sandbæk A, Borch-Johnsen K, Davies MJ, Khunti K, Lauritzen T, Rutten GE, van den Donk M, Wareham NJ, Griffin SJ

Diabetic medicine : a journal of the British Diabetic Association. Jul 2012

(DOI : 10.1111/j.1464-5491.2012.03759.x)

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Validity of self-assessed waist circumference in a multi-ethnic UK population.

Khunti K, Taub N, Webb D, Srinivasan B, Stockman J, Griffin SJ, Simmons RK, Davies MJ

Diabetic medicine : a journal of the British Diabetic Association. Oct 2011

(DOI : 10.1111/j.1464-5491.2011.03478.x)

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Intensive multifactorial intervention improves modelled coronary heart disease risk in screen-detected Type 2 diabetes mellitus: a cluster randomized controlled trial.

Webb DR, Khunti K, Gray LJ, Srinivasan BT, Farooqi A, Wareham NJ, Griffin SC, Davies MJ

Diabetic medicine : a journal of the British Diabetic Association. Sep 2011

(DOI : 10.1111/j.1464-5491.2011.03441.x)

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Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trial.

Griffin SJ, Borch-Johnsen K, Davies MJ, Khunti K, Rutten GE, Sandbæk A, Sharp SJ, Simmons RK, van den Donk M, Wareham NJ, Lauritzen T

Lancet (London, England). Jun 2011

(DOI : 10.1016/S0140-6736(11)60698-3)

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Screening for type 2 diabetes. Lessons from the ADDITION-Europe study.

van den Donk M, Sandbaek A, Borch-Johnsen K, Lauritzen T, Simmons RK, Wareham NJ, Griffin SJ, Davies MJ, Khunti K, Rutten GE

Diabetic medicine : a journal of the British Diabetic Association. Jun 2011

(DOI : 10.1111/j.1464-5491.2011.03365.x)

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Screening for diabetes using an oral glucose tolerance test within a western multi-ethnic population identifies modifiable cardiovascular risk: the ADDITION-Leicester study.

Webb DR, Gray LJ, Khunti K, Srinivasan B, Taub N, Campbell S, Barnett J, Farooqi A, Echouffo-Tcheugui JB, Griffin SJ, Wareham NJ, Davies MJ

Diabetologia. Oct 2010

(DOI : 10.1007/s00125-011-2189-2)

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Rationale and design of the ADDITION-Leicester study, a systematic screening programme and randomised controlled trial of multi-factorial cardiovascular risk intervention in people with type 2 diabetes mellitus detected by screening.

Webb DR, Khunti K, Srinivasan B, Gray LJ, Taub N, Campbell S, Barnett J, Henson J, Hiles S, Farooqi A, Griffin SJ, Wareham NJ, Davies MJ

Trials. Nov 2009

(DOI : 10.1186/1745-6215-11-16)

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