MRC Epidemiology Unit

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study => EPIC-Norfolk: The European Prospective Investigation into Cancer Norfolk Cohort

Plasma proteomic profiles identify biomarkers predicting Crohn's disease up to 16 years before onset.

Feng J, Chen S, Li Q, Long Y, Ma Y, Zhang L, Zeng R, Luo D, Meng M, Yu S, Chen C, Wu Y, Huang W, Zhang H, Li L, Leung FW, Duan C, Sha W, Chen H

Nature communications Dec 2025

(DOI : 10.1038/s41467-025-66483-4)

Association of neuroticism with incident dementia and cognitive function: 26-year follow-up of EPIC-Norfolk study.

Gao Y, Luben RN, Hayat S, Brayne C, Amin N, van Duijn C, Hunter D, Littlejohns T

Age and ageing Nov 2025

(DOI : 10.1093/ageing/afaf339)

Genetic Evidence Linking Lipoprotein(a) to Cardiovascular Disease and the Potential Role of Aspirin: A Mendelian Randomization Study.

Tan J, Xu W, Hu S, Wang J, Wang L, Zhu J, Yang Y

Reviews in cardiovascular medicine Nov 2025

(DOI : 10.31083/RCM39322)

Prospective evaluation of circulating plasma thyroid hormones concentrations and breast cancer risk in the EPIC cohort.

His M, Fournier A, Truong T, Gelot A, Navionis AS, Biessy C, Ferrari P, Tjønneland A, Kaaks R, Fortner RT, Schulze MB, Masala G, Sieri S, Tumino R, Catalano A, Gram IT, Olsen KS, Castro-Espin C, Guevara M, Aizpurua Atxega A, Chilarque MD, Tin Tin S, Heath A, Christakoudi S, Aglago EK, Gunter MJ, Rinaldi S

EBioMedicine Nov 2025

(DOI : 10.1016/j.ebiom.2025.106011)

Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition.

Vasson F, Matta K, Biessy C, S Antoniussen C, Fournier A, Marques C, Cadeau C, Le Cornet C, T Fortner R, Schulze MB, Sieri S, Panico S, Tumino R, Ricceri F, Masala G, Hiensch AE, Monninkhof EM, Agudo A, Guevara M, Colorado-Yohar SM, Sánchez MJ, Llorente A, Tin Tin S, Jackson IG, Gunter MJ, Botteri E, Ferrari P, Dossus L

Breast cancer research : BCR Oct 2025

(DOI : 10.1186/s13058-025-02148-w)

Differences in long-term impact of traditional risk factors for atherosclerosis on different arterial territories Insights from over 20 years of follow up in the EPIC-Norfolk prospective population study.

van den Bogaart M, Snaterse M, van Trier TJ, Peters RJG, Martens FMAC, Boekholdt SM, Jørstad HT

European Journal of Preventive Cardiology Oct 2025

(DOI : 10.1093/eurjpc/zwaf664)

Effect of the gut microbiota-derived tryptophan metabolite indole-3-acetic acid in pneumonia.

Kullberg RFJ, van Linge CCA, Haak BW, Paul PS, Butler JM, Wolff N, van Engelen TSR, Sikkens JJ, Bomers MK, Lefèvre A, Cremer OL, Roelofs JJTH, Sovran B, van den Wijngaard R, de Vos AF, de Jonge WJ, van der Poll T, Wiersinga WJ

Nature communications Sep 2025

(DOI : 10.1038/s41467-025-63611-y)

Circulating fatty acid binding protein 4 (FABP-4) concentrations and mortality in individuals with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study.

Pham TT, Nimptsch K, Aleksandrova K, Jenab M, Fedirko V, Olsen A, Tjønneland A, Cadeau C, Severi G, Schulze MB, Fortner RT, Katzke V, Agnoli C, Sacerdote C, Tumino R, Signoriello S, Trobajo-Sanmartín C, Gómez JH, Chirlaque MD, Sánchez MJ, Crous-Bou M, May A, Heath A, Aune D, Weiderpass E, Pischon T

International journal of cancer Aug 2025

(DOI : 10.1002/ijc.70090)

Plant-based dietary patterns and breast cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study.

Shah S, Laouali N, Mahamat-Saleh Y, Biessy C, Nicolas G, Rinaldi S, Zamora-Ros R, Papadimitriou N, Morales-Berstein F, Dahm CC, Christensen AKL, Mellemkjaer L, Nielsen AMO, Mancini FR, Ren X, Marques C, Katzke V, Le Cornet C, El-Khoury C, Schulze MB, Agnoli C, Simeon V, Tumino R, Milani L, Castro-Espin C, Sánchez MJ, Aizpurua A, Colorado-Yohar SM, Guevara M, Heath A, Aune D, Freisling H, Huybrechts I, Dossus L

European Journal of Epidemiology Jul 2025

(DOI : 10.1007/s10654-025-01277-y)

Changes in anticholinergic cognitive burden and risk of single and recurrent falls: population-based cohort study.

Xu XJ, Myint PK, Wong MC, Mat S, Lee SWH, Sami S, Tan MP

Age and ageing Jun 2025

(DOI : 10.1093/ageing/afaf177)

Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition.

Park JY, Van Puyvelde H, Regazzetti L, Clasen JL, Heath AK, Eussen S, Ueland PM, Johansson M, Biessy C, Zamora-Ros R, Huerta JM, Sánchez MJ, Ocke M, Schulze MB, Schiborn C, Braaten TB, Skeie G, Sacerdote C, Castilla J, Karlsson T, Johansson I, Kyrø C, Tjønneland A, Tong TYN, Katzke V, Bajracharya R, Lasheras C, Midttun Ø, Vollset SE, Vineis P, Masala G, Amiano P, Tumino R, Baldassari I, Weiderpass E, Riboli E, Gunter MJ, Freisling H, Rinaldi S, Muller DC, Huybrechts I, Ferrari P

Nutrients Jun 2025

(DOI : 10.3390/nu17121970)

The Association of Muscle-Related Factors With Glaucoma and Related Traits in a Large United Kingdom Population.

Madjedi KM, Stuart KV, Yin GS, Luben RN, Sun Z, Biradar M, Hu R, Foster PJ, Khaw PT, Bell KC, Crowston JG, Khawaja AP, UK Biobank Eye and Vision Consortium UK Biobank Eye and Vision Consortium

Investigative ophthalmology & visual science Jun 2025

(DOI : 10.1167/iovs.66.6.66)

Applying multimodal AI to physiological waveforms improves genetic prediction of cardiovascular traits.

Zhou Y, Khasentino J, Yun T, Biradar MI, Shreibati J, Lai D, Schwantes-An TH, Luben R, McCaw ZR, Engmann J, Providencia R, Schmidt AF, Munroe PB, Yang H, Carroll A, Khawaja AP, McLean CY, Behsaz B, Hormozdiari F

American journal of human genetics Jun 2025

(DOI : 10.1016/j.ajhg.2025.05.015)

Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?

Matta K, Viallon V, Chatziioannou AC, Robinot N, Wedekind R, Dahm CC, Rostgaard-Hansen AL, Tjønneland A, Truong T, Marques C, Frenoy P, Kaaks R, Fortner RT, Schulze MB, Sieri S, Fordellone M, Tumino R, Ricceri F, Braaten T, Nøst TH, Sánchez MJ, Mokoroa-Carollo O, Colorado-Yohar S, Trobajo-Sanmartín C, Papier K, Harewood R, Tsilidis K, Vaccarella S, Johansson M, Weiderpass E, Delpierre C, Lamy S, Borch KB, Keski-Rahkonen P, Riboli E, Freisling H, Gunter M, Ferrari P

Cancer & metabolism Jun 2025

(DOI : 10.1186/s40170-025-00388-0)

The Association of the Planetary Health Diet With Type 2 Diabetes Incidence: Findings From the EPIC-Norfolk Study

Forouhi NG, Forouhi N, Wareham NJ, Wareham N, Sowah SA, Imamura F, Ibsen DB

Current developments in nutrition May 2025

(DOI : 10.1016/j.cdnut.2025.106490)

Causal Relationship Between Blood Metabolites and Prostate Cancer Risk: A Two-Sample Mendelian Randomization Study.

Liu S, Zhu J, Zhang H, Zhong H, Wong HTH, Wang L, Wu L

Molecular carcinogenesis May 2025

(DOI : 10.1002/mc.23929)

Allelic effects on KLHL17 expression underlie a pancreatic cancer genome-wide association signal at chr1p36.33.

Connelly KE, Hullin K, Abdolalizadeh E, Zhong J, Eiser D, O'Brien A, Collins I, Das S, Duncan G, Pancreatic Cancer Cohort Consortium Pancreatic Cancer Cohort Consortium, Pancreatic Cancer Case-Control Consortium Pancreatic Cancer Case-Control Consortium, Chanock SJ, Stolzenberg-Solomon RZ, Klein AP, Wolpin BM, Hoskins JW, Andresson T, Smith JP, Amundadottir LT

Nature communications Apr 2025

(DOI : 10.1038/s41467-025-59109-2)

Combined associations of physical activity, diet quality and their trajectories with incidence of diabetes and cardiovascular diseases in the EPIC-Norfolk Study.

Aryannezhad S, Imamura F, Mok A, Wareham NJ, Forouhi NG, Brage S, Wareham N, Forouhi N

Scientific reports Apr 2025

(DOI : 10.1038/s41598-025-93679-x)

A Prospective Study Consortium for the Discovery and Validation of Early Detection Markers for Ovarian Cancer - Baseline Findings for CA125.

Kaaks R, Cooley V, Mukama T, Teras LR, Patel AV, Masala G, Crous-Bou M, Harris HR, Langseth H, Surcel HM, Wentzensen N, Terry K, Sasamoto N, Tworoger S, Fortner RT

Clinical cancer research : an official journal of the American Association for Cancer Research Apr 2025

(DOI : 10.1158/1078-0432.CCR-24-1845)

Low-density lipoprotein cholesterol, C-reactive protein, and lipoprotein(a) universal one-time screening in primary prevention: the EPIC-Norfolk study.

Kraaijenhof JM, Nurmohamed NS, Nordestgaard AT, Reeskamp LF, Stroes ESG, Hovingh GK, Boekholdt SM, Ridker PM

European heart journal Apr 2025

(DOI : 10.1093/eurheartj/ehaf209)

Assessing the influence of plasma metabolites on chronic skin ulcer risk: a two-sample Mendelian randomization study.

Ye Z, Hong D, Yuan J, Xu P, Liu W

Scientific reports Mar 2025

(DOI : 10.1038/s41598-025-94311-8)

The role of systemic inflammation in remnant cholesterol associated cardiovascular risk: insights from the EPIC-Norfolk study.

Kraaijenhof JM, Kerkvliet MJ, Nurmohamed NS, Grefhorst A, Kroon J, Wareham NJ, Hovingh GK, Stroes ESG, Boekholdt SM, Reeskamp LF

European Journal of Preventive Cardiology Feb 2025

(DOI : 10.1093/eurjpc/zwaf037)

Revealing the limitations of 10-year MACE observations: 20-year observed total cardiovascular burden in the EPIC-Norfolk study.

van Trier TJ, Snaterse M, Dorresteijn JA, van den Bogaart M, Scholte Op Reimer WJ, Visseren FL, Peters RJ, Jørstad HT, Boekholdt SM

Open heart Feb 2025

(DOI : 10.1136/openhrt-2024-002981)

Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort.

Gil-Lespinard M, Almanza-Aguilera E, Castañeda J, Guiñón-Fort D, Eriksen AK, Tjønneland A, Rothwell JA, Shah S, Cadeau C, Katzke V, Johnson T, Schulze MB, Oliverio A, Pasanisi F, Tumino R, Manfredi L, Masala G, Skeie G, Lundblad MW, Brustad M, Lasheras C, Crous-Bou M, Molina-Montes E, Colorado-Yohar S, Guevara M, Amiano P, Johansson I, Hultdin J, Forouhi NG, Freisling H, Merdas M, Debras C, Heath AK, Aglago EK, Aune D, Zamora-Ros R

Annals of nutrition & metabolism Jan 2025

(DOI : 10.1159/000535803)

The Cognitive Footprint of Medication Use.

Pinilla MS, Stoner CR, Knapp M, Nachev P, Rossor M

Brain and behavior Jan 2025

(DOI : 10.1002/brb3.70200)

Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology.

Rajesh AE, Olvera-Barrios A, Warwick AN, Wu Y, Stuart KV, Biradar MI, Ung CY, Khawaja AP, Luben R, Foster PJ, Cleland CR, Makupa WU, Denniston AK, Burton MJ, Bastawrous A, Keane PA, Chia MA, Turner AW, Lee CS, Tufail A, Lee AY, Egan C, UK Biobank Eye and Vision Consortium UK Biobank Eye and Vision Consortium

Nature communications Jan 2025

(DOI : 10.1038/s41467-024-55198-7)

Role of age and exposure duration in the association between metabolic syndrome and risk of incident dementia: a prospective cohort study.

Qureshi D, Luben R, Hayat S, Talarico R, Allen NE, Kuźma E, Littlejohns TJ

The lancet. Healthy longevity Nov 2024

(DOI : 10.1016/j.lanhl.2024.100652)

Role of age and exposure duration in the association between metabolic syndrome and risk of incident dementia: a prospective cohort study

Qureshi D, Luben R, Hayat S, Talarico R, Allen NE, Kuźma E, Littlejohns TJ

The Lancet Health Longevity Nov 2024

(DOI : 10.1016/j.lanhl.2024.100652)

The association of the planetary health diet with type 2 diabetes incidence and greenhouse gas emissions: Findings from the EPIC-Norfolk prospective cohort study.

Sowah SA, Imamura F, Ibsen DB, Monsivais P, Wareham NJ, Forouhi NG, Forouhi N

PLoS Medicine Nov 2024

(DOI : 10.1371/journal.pmed.1004633)

Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort.

Reichmann R, Nimptsch K, Pischon T, Gunter MJ, Jenab M, Eriksen AK, Tjonneland A, Janke J, Katzke V, Kaaks R, Schulze MB, Eichelmann F, Masala G, Sieri S, Pasanisi F, Tumino R, Giraudo MT, Rothwell J, Severi G, Jakszyn P, Sánchez-Pérez MJ, Amiano P, Colorado-Yohar SM, Guevara M, Van Guelpen B, Aglago EK, Heath AK, Smith-Byrne K, Weiderpass E, Aleksandrova K

International journal of cancer Nov 2024

(DOI : 10.1002/ijc.35205)

GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.

Luben RN, Luben R

Nature communications Nov 2024

(DOI : 10.1038/s41467-025-64949-z)

Prospective association of the Mediterranean diet with the onset of cardiometabolic multimorbidity in a UK-based cohort: the EPIC-Norfolk study.

Wang Q, Schmidt AF, Wannamethee SG

The Journal of nutrition Oct 2024

(DOI : 10.1016/j.tjnut.2024.10.027)

Combined associations of physical activity, diet quality and their changes over time with mortality: findings from the EPIC-Norfolk study, United Kingdom.

Aryannezhad S, Mok A, Imamura F, Wareham NJ, Brage S, Forouhi NG

BMC medicine Oct 2024

(DOI : 10.1186/s12916-024-03668-6)

Genetic Variance in Heparan Sulfation Is Associated With Salt Sensitivity.

Oppelaar JJ, Ferwerda B, Romman MA, Sahebdin GN, Zwinderman AH, Galenkamp H, Boekholdt SM, van den Born BH, Olde Engberink RHG, Vogt L

Hypertension (Dallas, Tex. : 1979) Sep 2024

(DOI : 10.1161/HYPERTENSIONAHA.124.23421)

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.

Willis TW, Gkrania-Klotsas E, Wareham NJ, McKinney EF, Lyons PA, Smith KGC, Wallace C

Clinical immunology (Orlando, Fla.) Sep 2024

(DOI : 10.1016/j.clim.2024.110356)

The Dietary Inflammatory Index and Its Associations with Biomarkers of Nutrients with Antioxidant Potential, a Biomarker of Inflammation and Multiple Long-Term Conditions.

Mulligan AA, Lentjes MAH, Skinner J, Welch AA

Antioxidants (Basel, Switzerland) Aug 2024

(DOI : 10.3390/antiox13080962)

Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization.

Alwan H, Luan J, Williamson A, Carrasco-Zanini J, Stewart ID, Wareham NJ, Langenberg C, Pietzner M

EBioMedicine Aug 2024

(DOI : 10.1016/j.ebiom.2024.105306)

Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries.

Li C, Bishop TRP, Imamura F, Sharp SJ, Pearce M, Brage S, Ong KK, Ahsan H, Bes-Rastrollo M, Beulens JWJ, den Braver N, Byberg L, Canhada S, Chen Z, Chung HF, Cortes-Valencia A, Djoussé L, Drouin-Chartier JP, Du H, Du S, Duncan BB, Gaziano JM, Gordon-Larsen P, Goto A, Haghighatdoost F, Härkänen T, Hashemian M, Hu FB, Ittermann T, Järvinen R, Kakkoura MG, Neelakantan N, Knekt P, Lajous M, Li Y, Magliano DJ, Malekzadeh R, Le Marchand L, Marques-Vidal P, Martínez-González MÁ, Maskarinec G, Mishra GD, Mohammadifard N, O'Donoghue G, O'Gorman D, Popkin B, Poustchi H, Sarrafzadegan N, Sawada N, Schmidt MI, Shaw JE, Soedamah-Muthu S, Stern D, Tong L, van Dam RM, Völzke H, Willett WC, Wolk A, Yu C, EPIC-InterAct Consortium EPIC-InterAct Consortium, Forouhi NG, Wareham NJ

The lancet. Diabetes & endocrinology Aug 2024

(DOI : 10.1016/S2213-8587(24)00179-7)

Proteomic signatures improve risk prediction for common and rare diseases.

Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C, Grünschläger F, Fitzpatrick N, Ytsma C, Kanno T, Gade S, Freitag D, Ziebell F, Haas S, Denaxas S, Betts JC, Wareham NJ, Hemingway H, Scott RA, Langenberg C

Nature medicine Jul 2024

(DOI : 10.1038/s41591-024-03142-z)

How many future dementia cases would be missed by a high-risk screening program? A retrospective cohort study in a population-based cohort.

Walsh S, Wallace L, Merrick R, Hayat S, Luben R, Mytton O, Lafortune L, Brayne C

Alzheimer's & dementia : the journal of the Alzheimer's Association Jul 2024

(DOI : 10.1002/alz.14113)

Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study.

Carrasco-Zanini J, Pietzner M, Koprulu M, Wheeler E, Kerrison ND, Wareham NJ, Langenberg C

The Lancet. Digital health Jun 2024

(DOI : 10.1016/S2589-7500(24)00087-6)

An increasing proportion of the population is not covered by the current RDA for vitamin C - interrogation of EPIC-Norfolk and NHANES 2017/2018 cohorts.

Carr AC, Myint PK, Vijewardane SC, Johnstone AM, Crook J, Lykkesfeldt J

Critical reviews in food science and nutrition Jun 2024

(DOI : 10.1080/10408398.2024.2356760)

Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study.

Mayén AL, Sabra M, Aglago EK, Perlemuter G, Voican C, Ramos I, Debras C, Blanco J, Viallon V, Ferrari P, Olsen A, Tjønneland A, Langmann F, Dahm CC, Rothwell J, Laouali N, Marques C, Schulze MB, Katzke V, Kaaks R, Palli D, Macciotta A, Panico S, Tumino R, Agnoli C, Farràs M, Molina-Montes E, Amiano P, Chirlaque MD, Castilla J, Werner M, Bodén S, Heath AK, Tsilidis K, Aune D, Weiderpass E, Freisling H, Gunter MJ, Jenab M

BMC medicine Jun 2024

(DOI : 10.1186/s12916-024-03366-3)

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause.

Yazdanpanah M, Yazdanpanah N, Gamache I, Ong K, Perry JRB, Manousaki D

Genome medicine May 2024

(DOI : 10.1186/s13073-024-01322-7)

Sugar-Sweetened Beverage Consumption and Height Loss in Adults: A Longitudinal Analysis in the EPIC-Norfolk Study.

Lee JY, Imamura F

The Journal of nutrition May 2024

(DOI : 10.1016/j.tjnut.2024.05.007)

Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study.

Lu T, Chen Y, Yoshiji S, Ilboudo Y, Forgetta V, Zhou S, Greenwood CMT

Biological psychiatry May 2024

(DOI : 10.1016/j.biopsych.2024.04.016)

Replacement of saturated fatty acids from meat by dairy sources in relation to incident cardiovascular disease: The European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk study.

Vogtschmidt YD, Soedamah-Muthu SS, Imamura F, Givens DI, Lovegrove JA

The American Journal of Clinical Nutrition Apr 2024

(DOI : 10.1016/j.ajcnut.2024.04.007)

A pleiotropy scan to discover new susceptibility loci for pancreatic ductal adenocarcinoma.

Giaccherini M, Rende M, Gentiluomo M, Corradi C, Archibugi L, Ermini S, Maiello E, Morelli L, van Eijck CHJ, Cavestro GM, Schneider M, Mickevicius A, Adamonis K, Basso D, Hlavac V, Gioffreda D, Talar-Wojnarowska R, Schöttker B, Lovecek M, Vanella G, Gazouli M, Uno M, Malecka-Wojciesko E, Vodicka P, Goetz M, Bijlsma MF, Petrone MC, Bazzocchi F, Kiudelis M, Szentesi A, Carrara S, Nappo G, Brenner H, Milanetto AC, Souček P, Katzke V, Peduzzi G, Rizzato C, Pasquali C, Chen X, Capurso G, Hackert T, Bueno-de-Mesquita B, Uzunoglu FGG, Hegyi P, Greenhalf W, Theodoropoulos GEE, Sperti C, Perri F, Oliverius M, Mambrini A, Tavano F, Farinella R, Arcidiacono PG, Lucchesi M, Bunduc S, Kupcinskas J, Di Franco G, Stocker S, Neoptolemos JP, Bambi F, Jamroziak K, Testoni SGG, Aoki MN, Mohelnikova-Duchonova B, Izbicki JR, Pezzilli R, Lawlor RT, Kauffmann EF, López de Maturana E, Malats N, Canzian F, Campa D

Mutagenesis Apr 2024

(DOI : 10.1093/mutage/geae012)

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.

Thériault S, Li Z, Abner E, Luan J, Manikpurage HD, Houessou U, Zamani P, Briend M, Estonian Biobank Research Team Estonian Biobank Research Team, Boudreau DK, Gaudreault N, Frenette L, Argaud D, Dahmene M, Dagenais F, Clavel MA, Pibarot P, Arsenault BJ, Boekholdt SM, Wareham NJ, Esko T, Mathieu P, Bossé Y

Nature communications Mar 2024

(DOI : 10.1038/s41467-024-46639-4)

Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case-cohort study.

Zheng JS, Steur M, Imamura F, Freisling H, Johnson L, van der Schouw YT, Tong TY, Weiderpass E, Bajracharya R, Crous-Bou M, Dahm CC, Heath AK, Ibsen DB, Jannasch F, Katzke V, Masala G, Moreno-Iribas C, Sacerdote C, Schulze MB, Sieri S, Wareham NJ, Danesh J, Butterworth AS, Forouhi NG

The American Journal of Clinical Nutrition Mar 2024

(DOI : 10.1016/j.ajcnut.2024.03.006)

Cross-cultural adaptation and reproducibility of the EPIC-Norfolk food frequency questionnaire in young people living in Croatia.

Davidović Cvetko E, Drenjančević I, Jukić I, Stupin A, Šušnjara P, Vulin M, Kos M, Lukic M, Stanojević L

Croatian medical journal Mar 2024

(DOI : 10.3325/cmj.2024.65.20)

Systemic proteome adaptions to 7-day complete caloric restriction in humans.

Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS, Wojtaszewski JFP, Kolnes AJ, Yeo GSH, O'Rahilly S, Jensen J, Langenberg C

Nature metabolism Mar 2024

(DOI : 10.1038/s42255-024-01008-9)

Visual processing speed and its association with future dementia development in a population-based prospective cohort: EPIC-Norfolk.

Begde A, Wilcockson T, Brayne C, Hogervorst E

Scientific reports Feb 2024

(DOI : 10.1038/s41598-024-55637-x)

Dietary intake of dicarbonyl compounds and changes in body weight over time in a large cohort of European adults.

Debras C, Cordova R, Mayén AL, Maasen K, Knaze V, Eussen SJPM, Schalkwijk CG, Huybrechts I, Tjønneland A, Halkjær J, Katzke V, Bajracharya R, Schulze MB, Masala G, Pala V, Pasanisi F, Macciotta A, Petrova D, Castañeda J, Santiuste C, Amiano P, Moreno-Iribas C, Borné Y, Sonestedt E, Johansson I, Esberg A, Aglago EK, Jenab M, Freisling H

The British journal of nutrition Feb 2024

(DOI : 10.1017/S0007114524000503)

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.

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Nature Feb 2024

(DOI : 10.1038/s41586-024-07019-6)

The Relationship between Mushroom Intake and Cognitive Performance: An Epidemiological Study in the European Investigation of Cancer-Norfolk Cohort (EPIC-Norfolk).

Cha S, Bell L, Williams CM

Nutrients Feb 2024

(DOI : 10.3390/nu16030353)

Prospective associations between changes in physical activity and sedentary time and subsequent lean muscle mass in older English adults: the EPIC-Norfolk cohort study.

Yerrakalva D, Hajna S, Khaw KT, Griffin SJ, Brage S

The international journal of behavioral nutrition and physical activity Jan 2024

(DOI : 10.1186/s12966-023-01547-6)

A meta-analysis of previous falls and subsequent fracture risk in cohort studies.

Vandenput L, Johansson H, McCloskey EV, Liu E, Schini M, Åkesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyère O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Glüer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kröger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, McGuigan FEA, Mellström D, Merlijn T, Nguyen TV, Nordström A, Nordström P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens M, Zwart M, Harvey NC, Lorentzon M, Leslie WD, Kanis JA

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Jan 2024

(DOI : 10.1007/s00198-023-07012-1)

Plasma Metabolites Related to the Consumption of Different Types of Dairy Products and Their Association with New-Onset Type 2 Diabetes: Analyses in the Fenland and EPIC-Norfolk Studies, United Kingdom.

Trichia E, Koulman A, Stewart ID, Brage S, Griffin SJ, Griffin JL, Khaw KT, Langenberg C, Wareham NJ, Imamura F, Forouhi NG

Molecular nutrition & food research Dec 2023

(DOI : 10.1002/mnfr.202300154)

Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study.

Pana TA, Mamas MA, Wareham NJ, Khaw KT, Dawson DK, Myint PK

European Journal of Preventive Cardiology Nov 2023

(DOI : 10.1093/eurjpc/zwad283)

Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study.

Teunis CJ, Stroes ESG, Boekholdt SM, Wareham NJ, Murphy AJ, Nieuwdorp M, Hazen SL, Hanssen NMJ

Atherosclerosis Nov 2023

(DOI : 10.1016/j.atherosclerosis.2023.117344)

Lower mental health related quality of life precedes dementia diagnosis: findings from the EPIC-Norfolk prospective population-based study.

Chintapalli R, Myint PK, Brayne C, Hayat S, Keevil VL

European Journal of Epidemiology Oct 2023

(DOI : 10.1007/s10654-023-01064-7)

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017-2018 and EPIC-Norfolk Cohorts.

Carr AC, Lunt H, Wareham NJ, Myint PK

Antioxidants (Basel, Switzerland) Oct 2023

(DOI : 10.3390/antiox12101863)

Multi-omic prediction of incident type 2 diabetes.

Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ

Diabetologia Oct 2023

(DOI : 10.1007/s00125-023-06027-x)

Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer.

Nimptsch K, Aleksandrova K, Pham TT, Papadimitriou N, Janke J, Christakoudi S, Heath A, Olsen A, Tjønneland A, Schulze MB, Katzke V, Kaaks R, Van Guelpen B, Harbs J, Palli D, Macciotta A, Pasanisi F, Yohar SMC, Guevara M, Amiano P, Grioni S, Jakszyn PG, Figueiredo JC, Samadder NJ, Li CI, Moreno V, Potter JD, Schoen RE, Um CY, Weiderpass E, Jenab M, Gunter MJ, Pischon T

BMC medicine Oct 2023

(DOI : 10.1186/s12916-023-03104-1)

Validation of Systematic Coronary Risk Evaluation 2 (SCORE2) and SCORE2-Older Persons in the EPIC-Norfolk prospective population cohort.

van Trier TJ, Snaterse M, Boekholdt SM, Scholte Op Reimer WJM, Hageman SHJ, Visseren FLJ, Dorresteijn JAN, Peters RJG, Jørstad HT

European Journal of Preventive Cardiology Oct 2023

(DOI : 10.1093/eurjpc/zwad318)

Glycated Haemoglobin (HbA1c) and Future Physical and Mental Functional Health in the European Prospective Investigation into Cancer (EPIC)-Norfolk Population-Based Study.

McLachlan F, Johnstone AM, Myint PK

Journal of personalized medicine Sep 2023

(DOI : 10.3390/jpm13091336)

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A, Marullo L, Mägi R, Rujan RM, Ahlqvist E, Thorleifsson G, Gao Η, Εvangelou Ε, Benyamin B, Scott RA, Isaacs A, Zhao JH, Willems SM, Johnson T, Gieger C, Grallert H, Meisinger C, Müller-Nurasyid M, Strawbridge RJ, Goel A, Rybin D, Albrecht E, Jackson AU, Stringham HM, Corrêa IR, Farber-Eger E, Steinthorsdottir V, Uitterlinden AG, Munroe PB, Brown MJ, Schmidberger J, Holmen O, Thorand B, Hveem K, Wilsgaard T, Mohlke KL, Wang Z, GWA-PA Consortium GWA-PA Consortium, Shmeliov A, den Hoed M, Loos RJF, Kratzer W, Haenle M, Koenig W, Boehm BO, Tan TM, Tomas A, Salem V, Barroso I, Tuomilehto J, Boehnke M, Florez JC, Hamsten A, Watkins H, Njølstad I, Wichmann HE, Caulfield MJ, Khaw KT, van Duijn CM, Hofman A, Wareham NJ, Langenberg C, Whitfield JB, Martin NG, Montgomery G, Scapoli C, Tzoulaki I, Elliott P, Thorsteinsdottir U, Stefansson K, Brittain EL, McCarthy MI, Froguel P, Sexton PM, Wootten D, Groop L, Dupuis J, Meigs JB, Deganutti G, Demirkan A, Pers TH, Reynolds CA, Aulchenko YS, Kaakinen MA, Jones B, Prokopenko I, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC) Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)

Nature genetics Sep 2023

(DOI : 10.1038/s41588-023-01462-3)

The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk.

Lang A, Kuss O, Filla T, Kuhnle G, Schlesinger S

Nutrition & diabetes Sep 2023

(DOI : 10.1038/s41387-023-00243-5)

Association Between Retinal Nerve Fiber Layer Thickness and Incident Dementia in the European Prospective Investigation into Cancer in Norfolk Cohort.

Yin GS, van der Heide F, Littlejohns TJ, Kuźma E, Hayat S, Brayne C, Foster PJ, Luben R, Khawaja AP

Journal of Alzheimer's disease : JAD Aug 2023

(DOI : 10.3233/JAD-230073)

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Kanis JA, Johansson H, McCloskey EV, Liu E, Åkesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyère O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Glüer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kröger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, Mellström D, Merlijn T, Nordström A, Nordström P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens MC, Zwart M, Vandenput L, Harvey NC, Lorentzon M, Leslie WD

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Aug 2023

(DOI : 10.1007/s00198-023-06870-z)

Haemoglobin levels as a predictor for the occurrence of future cardiovascular events in adults-Sex-dependent results from the EPIC trial.

Jung C, Erkens R, Wischmann P, Piayda K, Kelm M, Kuhnle G

European journal of internal medicine Aug 2023

(DOI : 10.1016/j.ejim.2023.08.004)

Circulating metabolites modulated by diet are associated with depression.

van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S, Heinken A, Luik AI, Ladwig KH, Kastenmüller G, Menni C, Hertel J, Ikram MA, de Mutsert R, Suhre K, Gieger C, Strauch K, Völzke H, Meitinger T, Mangino M, Flaquer A, Waldenberger M, Peters A, Thiele I, Kaddurah-Daouk R, Dunlop BW, Rosendaal FR, Wareham NJ, Spector TD, Kunze S, Grabe HJ, Mook-Kanamori DO, Langenberg C, van Duijn CM, Amin N