MRC Epidemiology Unit

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study => EPIC-Norfolk: The European Prospective Investigation into Cancer Norfolk Cohort

Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study.

Teunis CJ, Stroes ESG, Boekholdt SM, Wareham NJ, Murphy AJ, Nieuwdorp M, Hazen SL, Hanssen NMJ

Atherosclerosis Nov 2023

(DOI : 10.1016/j.atherosclerosis.2023.117344)

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017-2018 and EPIC-Norfolk Cohorts.

Carr AC, Lunt H, Wareham NJ, Myint PK

Antioxidants (Basel, Switzerland) Oct 2023

(DOI : 10.3390/antiox12101863)

Glycated Haemoglobin (HbA1c) and Future Physical and Mental Functional Health in the European Prospective Investigation into Cancer (EPIC)-Norfolk Population-Based Study.

McLachlan F, Johnstone AM, Myint PK

Journal of personalized medicine Sep 2023

(DOI : 10.3390/jpm13091336)

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG, Chen S, Todorov PV, Sharapov S, David A, Marullo L, Mägi R, Rujan RM, Ahlqvist E, Thorleifsson G, Gao Η, Εvangelou Ε, Benyamin B, Scott RA, Isaacs A, Zhao JH, Willems SM, Johnson T, Gieger C, Grallert H, Meisinger C, Müller-Nurasyid M, Strawbridge RJ, Goel A, Rybin D, Albrecht E, Jackson AU, Stringham HM, Corrêa IR, Farber-Eger E, Steinthorsdottir V, Uitterlinden AG, Munroe PB, Brown MJ, Schmidberger J, Holmen O, Thorand B, Hveem K, Wilsgaard T, Mohlke KL, Wang Z, GWA-PA Consortium GWA-PA Consortium, Shmeliov A, den Hoed M, Loos RJF, Kratzer W, Haenle M, Koenig W, Boehm BO, Tan TM, Tomas A, Salem V, Barroso I, Tuomilehto J, Boehnke M, Florez JC, Hamsten A, Watkins H, Njølstad I, Wichmann HE, Caulfield MJ, Khaw KT, van Duijn CM, Hofman A, Wareham NJ, Langenberg C, Whitfield JB, Martin NG, Montgomery G, Scapoli C, Tzoulaki I, Elliott P, Thorsteinsdottir U, Stefansson K, Brittain EL, McCarthy MI, Froguel P, Sexton PM, Wootten D, Groop L, Dupuis J, Meigs JB, Deganutti G, Demirkan A, Pers TH, Reynolds CA, Aulchenko YS, Kaakinen MA, Jones B, Prokopenko I, Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC) Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)

Nature genetics Sep 2023

(DOI : 10.1038/s41588-023-01462-3)

The mediating role of obesity on the prospective association between urinary sucrose and diabetes incidence in a sub-cohort of the EPIC-Norfolk.

Lang A, Kuss O, Filla T, Kuhnle G, Schlesinger S

Nutrition & diabetes Sep 2023

(DOI : 10.1038/s41387-023-00243-5)

Association Between Retinal Nerve Fiber Layer Thickness and Incident Dementia in the European Prospective Investigation into Cancer in Norfolk Cohort.

Yin GS, van der Heide F, Littlejohns TJ, Kuźma E, Hayat S, Brayne C, Foster PJ, Luben R, Khawaja AP

Journal of Alzheimer's disease : JAD Aug 2023

(DOI : 10.3233/JAD-230073)

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Kanis JA, Johansson H, McCloskey EV, Liu E, Åkesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyère O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Glüer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kröger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, Mellström D, Merlijn T, Nordström A, Nordström P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens MC, Zwart M, Vandenput L, Harvey NC, Lorentzon M, Leslie WD

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Aug 2023

(DOI : 10.1007/s00198-023-06870-z)

Circulating metabolites modulated by diet are associated with depression.

van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S, Heinken A, Luik AI, Ladwig KH, Kastenmüller G, Menni C, Hertel J, Ikram MA, de Mutsert R, Suhre K, Gieger C, Strauch K, Völzke H, Meitinger T, Mangino M, Flaquer A, Waldenberger M, Peters A, Thiele I, Kaddurah-Daouk R, Dunlop BW, Rosendaal FR, Wareham NJ, Spector TD, Kunze S, Grabe HJ, Mook-Kanamori DO, Langenberg C, van Duijn CM, Amin N

Molecular psychiatry Jul 2023

(DOI : 10.1038/s41380-023-02180-2)

Lipopolysaccharide-binding protein and future Parkinson's disease risk: a European prospective cohort.

Zhao Y, Walker DI, Lill CM, Bloem BR, Darweesh SKL, Pinto-Pacheco B, McNeil B, Miller GW, Heath AK, Frissen M, Petrova D, Sánchez MJ, Chirlaque MD, Guevara M, Zibetti M, Panico S, Middleton L, Katzke V, Kaaks R, Riboli E, Masala G, Sieri S, Zamora-Ros R, Amiano P, Jenab M, Peters S, Vermeulen R

Journal of neuroinflammation Jul 2023

(DOI : 10.1186/s12974-023-02846-2)

Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation.

Qian F, Tintle N, Jensen PN, Lemaitre RN, Imamura F, Feldreich TR, Nomura SO, Guan W, Laguzzi F, Kim E, Virtanen JK, Steur M, Bork CS, Hirakawa Y, O'Donoghue ML, Sala-Vila A, Ardisson Korat AV, Sun Q, Rimm EB, Psaty BM, Heckbert SR, Forouhi NG, Wareham NJ, Marklund M, Riserus U, Lind L, Ärnlöv J, Garg P, Tsai MY, Pankow J, Misialek JR, Gigante B, Leander K, Pester JA, Albert CM, Kavousi M, Ikram A, Voortman T, Schmidt EB, Ninomiya T, Morrow DA, Bayés-Genís A, O'Keefe JH, Ong KL, Wu JHY, Mozaffarian D, Harris WS, Siscovick DS, Fatty Acids and Outcomes Research Consortium (FORCE) Fatty Acids and Outcomes Research Consortium (FORCE)

Journal of the American College of Cardiology Jul 2023

(DOI : 10.1016/j.jacc.2023.05.024)

Associations between change in physical activity and sedentary time and health-related quality of life in older english adults: the EPIC-Norfolk cohort study.

Yerrakalva D, Hajna S, Suhrcke M, Wijndaele K, Westgate K, Khaw KT, Wareham N, Brage S, Griffin S

Health and quality of life outcomes Jun 2023

(DOI : 10.1186/s12955-023-02137-7)

Taurine deficiency as a driver of aging.

Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK

Science (New York, N.Y.) Jun 2023

(DOI : 10.1126/science.abn9257)

Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes: the EPIC-InterAct case-cohort study.

Lampousi AM, Carlsson S, Löfvenborg JE, Cabrera-Castro N, Chirlaque MD, Fagherazzi G, Franks PW, Hampe CS, Jakszyn P, Koulman A, Kyrø C, Moreno-Iribas C, Nilsson PM, Panico S, Papier K, van der Schouw YT, Schulze MB, Weiderpass E, Zamora-Ros R, Forouhi NG, Sharp SJ, Rolandsson O, Wareham NJ

Diabetologia Jun 2023

(DOI : 10.1007/s00125-023-05948-x)

High Immunoglobulin-M Levels to Oxidation-Specific Epitopes Are Associated with Lower Risk of Acute Myocardial Infarction.

Taleb A, Willeit P, Amir S, Perkmann T, Kozma MO, Watzenböck ML, Binder CJ, Witztum JL, Tsimikas S

Journal of lipid research May 2023

(DOI : 10.1016/j.jlr.2023.100391)

Association of systemic medication use with glaucoma and intraocular pressure: the E3 Consortium.

Vergroesen JE, Schuster AK, Stuart KV, Asefa NG, Cougnard-Gregoire A, Delcourt C, Schweitzer C, Barreto P, Coimbra R, Foster PJ, Luben RN, Pfeiffer N, Stingl JV, Kirsten T, Rauscher FG, Wirkner K, Jansonius NM, Arnould L, Creuzot-Garcher CP, Stricker BH, Keskini C, Topouzis F, Bertelsen G, Eggen AE, Bikbov MM, Jonas JB, Klaver CCW, Ramdas WD, Khawaja AP, European Eye Epidemiology (E3) Consortium European Eye Epidemiology (E3) Consortium

Ophthalmology May 2023

(DOI : 10.1016/j.ophtha.2023.05.001)

Calcaneal broadband ultrasound attenuation predicts physical capability: EPIC-Norfolk prospective population-based study.

Perrott SL, Martin K, Keevil VL, Wareham NJ, Khaw KT, Myint PK

Maturitas May 2023

(DOI : 10.1016/j.maturitas.2023.04.008)

Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.

Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ

European heart journal open Mar 2023

(DOI : 10.1093/ehjopen/oead032)

Proteogenomic links to human metabolic diseases.

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C

Nature metabolism Feb 2023

(DOI : 10.1038/s42255-023-00753-7)

Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.

Yammine SG, Huybrechts I, Biessy C, Dossus L, Panico S, Sánchez MJ, Benetou V, Turzanski-Fortner R, Katzke V, Idahl A, Skeie G, Olsen KS, Tjønneland A, Halkjaer J, Colorado-Yohar S, Heath AK, Sonestedt E, Sartor H, Schulze MB, Palli D, Crous-Bou M, Dorronsoro A, Overvad K, Gurrea AB, Severi G, Vermeulen RCH, Sandanger TM, Travis RC, Key T, Amiano P, Van Guelpen B, Johansson M, Sund M, Tumino R, Wareham N, Sacerdote C, Krogh V, Brennan P, Riboli E, Weiderpass E, Gunter MJ, Chajès V

BMC cancer Feb 2023

(DOI : 10.1186/s12885-023-10611-0)

Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study.

Castañeda J, Gil-Lespinard M, Almanza-Aguilera E, Llaha F, Gómez JH, Bondonno N, Tjønneland A, Overvad K, Katzke V, Schulze MB, Masala G, Agnoli C, Santucci De Magistris M, Tumino R, Sacerdote C, Skeie G, Brustad M, Lasheras C, Molina-Montes E, Chirlaque MD, Barricarte A, Sonestedt E, da Silva M, Johansson I, Hultdin J, May AM, Forouhi NG, Heath AK, Freisling H, Weiderpass E, Scalbert A, Zamora-Ros R

Obesity (Silver Spring, Md.) Jan 2023

(DOI : 10.1002/oby.23689)

Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.

Kentistou KA, Luan J, Wittemans LBL, Hambly C, Klaric L, Kutalik Z, Speakman JR, Wareham NJ, Kendall TJ, Langenberg C, Wilson JF, Joshi PK, Morton NM

Nature communications Jan 2023

(DOI : 10.1038/s41467-022-35563-0)

Bidirectional associations of accelerometer-assessed physical activity and sedentary time with physical function among older English adults: the EPIC-Norfolk cohort study.

Yerrakalva D, Hajna S, Wijndaele K, Dempsey PC, Westgate K, Wareham N, Griffin SJ, Brage S

European journal of ageing Dec 2022

(DOI : 10.1007/s10433-022-00733-y)

Body Fat Percentage and the Long-term Risk of Fractures. The EPIC-Norfolk Prospective Population Cohort Study.

Pana TA, Kioh SH, Neal SR, Tan MP, Mat S, Moayyeri A, Luben RN, Wareham NJ, Khaw KT, Myint PK

Maturitas Dec 2022

(DOI : 10.1016/j.maturitas.2022.11.005)

Proteomic signatures for identification of impaired glucose tolerance.

Carrasco-Zanini J, Pietzner M, Lindbohm JV, Wheeler E, Oerton E, Kerrison N, Simpson M, Westacott M, Drolet D, Kivimaki M, Ostroff R, Williams SA, Wareham NJ, Langenberg C

Nature medicine Nov 2022

(DOI : 10.1038/s41591-022-02055-z)

Rare and common genetic determinants of metabolic individuality and their effects on human health.

Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J, Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C

Nature medicine Nov 2022

(DOI : 10.1038/s41591-022-02046-0)

Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: the EPIC prospective cohort.

Allione A, Viberti C, Cotellessa I, Catalano C, Casalone E, Cugliari G, Russo A, Guarrera S, Mirabelli D, Sacerdote C, Gentile M, Eichelmann F, Schulze MB, Harlid S, Eriksen AK, Tjønneland A, Andersson M, Dollé MET, Van Puyvelde H, Weiderpass E, Rodriguez-Barranco M, Agudo A, Heath AK, Chirlaque MD, Truong T, Dragic D, Severi G, Sieri S, Sandanger TM, Ardanaz E, Vineis P, Matullo G

International journal of cancer Sep 2022

(DOI : 10.1002/ijc.34339)

Association between Legume Consumption and Risk of Hypertension in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Cohort.

Hartley M, Fyfe CL, Wareham NJ, Khaw KT, Johnstone AM, Myint PK

Nutrients Aug 2022

(DOI : 10.3390/nu14163363)

Immunodeficiency, autoimmunity, and increased risk of B cell malignancy in humans with mutations.

Rae W, Sowerby JM, Verhoeven D, Youssef M, Kotagiri P, Savinykh N, Coomber EL, Boneparth A, Chan A, Gong C, Jansen MH, du Long R, Santilli G, Simeoni I, Stephens J, Wu K, Zinicola M, Allen HL, Baxendale H, Kumararatne D, Gkrania-Klotsas E, Scheffler Mendoza SC, Yamazaki-Nakashimada MA, Ruiz LB, Rojas-Maruri CM, Lugo Reyes SO, Lyons PA, Williams AP, Hodson DJ, Bishop GA, Thrasher AJ, Thomas DC, Murphy MP, Vyse TJ, Milner JD, Kuijpers TW, Smith KGC

Science immunology Aug 2022

(DOI : 10.1126/sciimmunol.abn3800)

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution.

Kuo FC, Neville MJ, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans LBL, van Dam AD, Loh NY, Todorčević M, Denton N, Kentistou KA, Joshi PK, Christodoulides C, Langenberg C, Collas P, Karpe F, Pinnick KE

Cell reports Jul 2022

(DOI : 10.1016/j.celrep.2022.111136)

The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses

Taylor K, McBride N, Zhao J, Oddie S, Azad R, Wright J, Andreassen OA, Stewart ID, Langenberg C, Magnus MC, Borges MC, Caputo M, Lawlor DA

Journal of Cardiovascular Development and Disease Jul 2022

(DOI : 10.3390/jcdd9080237)

Sex-specific associations between potassium intake, blood pressure, and cardiovascular outcomes: the EPIC-Norfolk study.

Wouda RD, Boekholdt SM, Khaw KT, Wareham NJ, de Borst MH, Hoorn EJ, Rotmans JI, Vogt L

European heart journal Jul 2022

(DOI : 10.1093/eurheartj/ehac313)

Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.

Peduzzi G, Archibugi L, Katzke V, Gentiluomo M, Capurso G, Milanetto AC, Gazouli M, Goetz M, Brenner H, Vermeulen RCH, Talar-Wojnarowska R, Vanella G, Tavano F, Lucchesi M, Mohelnikova-Duchonova B, Chen X, Kiudelis V, Hegyi P, Oliverius M, Stocker H, Stornello C, Vodickova L, Souček P, Neoptolemos JP, Testoni SGG, Morelli L, Lawlor RT, Basso D, Izbicki JR, Ermini S, Kupcinskas J, Pezzilli R, Boggi U, van Laarhoven HWM, Szentesi A, Erőss B, Capretti G, Schöttker B, Skieceviciene J, Aoki MN, van Eijck CHJ, Cavestro GM, Canzian F, Campa D

Scientific reports Jul 2022

(DOI : 10.1038/s41598-022-22973-9)

Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study.

Ried-Larsen M, Rasmussen MG, Blond K, Overvad TF, Overvad K, Steindorf K, Katzke V, Andersen JLM, Petersen KEN, Aune D, Tsilidis KK, Heath AK, Papier K, Panico S, Masala G, Pala V, Weiderpass E, Freisling H, Bergmann MM, Verschuren WMM, Zamora-Ros R, Colorado-Yohar SM, Spijkerman AMW, Schulze MB, Ardanaz EMA, Andersen LB, Wareham N, Brage S, Grøntved A

JAMA internal medicine Jul 2022

(DOI : 10.1001/jamainternmed.2021.3836)

Food Processing and Risk of Crohn's Disease and Ulcerative Colitis: A European Prospective Cohort Study.

Meyer A, Dong C, Casagrande C, Chan SSM, Huybrechts I, Nicolas G, Rauber F, Levy RB, Millett C, Oldenburg B, Weiderpass E, Heath AK, Tong TYN, Tjønneland A, Kyrø C, Kaaks R, Katzke VA, Bergman MM, Palli D, Masala G, Tumino R, Sacerdote C, Colorado-Yohar SM, Sánchez MJ, Grip O, Lindgren S, Luben R, Gunter MJ, Mahamat-Saleh Y, Boutron-Ruault MC, Carbonnel F

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association Jun 2022

(DOI : 10.1016/j.cgh.2022.09.031)

GWAS on retinal vasculometry phenotypes.

Jiang X, Hysi PG, Khawaja AP, Mahroo OA, Xu Z, Hammond CJ, Foster PJ, Welikala RA, Barman SA, Whincup PH, Rudnicka AR, Owen CG, Strachan DP, UK Biobank Eye and Vision Consortium UK Biobank Eye and Vision Consortium

PLoS genetics Jun 2022

(DOI : 10.1371/journal.pgen.1010583)

Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans.

Mauschitz MM, Verzijden T, Schuster AK, Elbaz H, Pfeiffer N, Khawaja A, Luben RN, Foster PJ, Rauscher FG, Wirkner K, Kirsten T, Jonas JB, Bikbov MM, Hogg R, Peto T, Cougnard-Gregoire A, Bertelsen G, Erke MG, Topouzis F, Giannoulis DA, Brandl C, Heid IM, Creuzot-Garcher CP, Gabrielle PH, Hense HW, Pauleikhoff D, Barreto P, Coimbra R, Piermarocchi S, Daien V, Holz FG, Delcourt C, Finger RP, European Eye Epidemiology (E3) Consortium European Eye Epidemiology (E3) Consortium

The British journal of ophthalmology Jun 2022

(DOI : 10.1136/bjo-2022-321985)

Relationship of Sodium Intake With Granulocytes, Renal and Cardiovascular Outcomes in the Prospective EPIC-Norfolk Cohort.

Wenstedt EFE, Peters Sengers H, Boekholdt SM, Khaw KT, Wareham NJ, van den Born BH, Vogt L

Journal of the American Heart Association Jun 2022

(DOI : 10.1161/JAHA.121.023727)

Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).

Mahamat-Saleh Y, Al-Rahmoun M, Severi G, Ghiasvand R, Veierod MB, Caini S, Palli D, Botteri E, Sacerdote C, Ricceri F, Lukic M, Sánchez MJ, Pala V, Tumino R, Chiodini P, Amiano P, Colorado-Yohar S, Chirlaque MD, Ardanaz E, Bonet C, Katzke V, Kaaks R, Schulze MB, Overvad K, Dahm CC, Antoniussen CS, Tjønneland A, Kyrø C, Bueno-de-Mesquita B, Manjer J, Jansson M, Esberg A, Mori N, Ferrari P, Weiderpass E, Boutron-Ruault MC, Kvaskoff M

International journal of cancer Jun 2022

(DOI : 10.1002/ijc.34253)

Evaluation of routinely collected records for dementia outcomes in UK: a prospective cohort study.

Hayat S, Luben R, Khaw KT, Wareham N, Brayne C

BMJ Open Jun 2022

(DOI : 10.1136/bmjopen-2022-060931)

Using genetic variation to disentangle the complex relationship between food intake and health outcomes.

Pirastu N, McDonnell C, Grzeszkowiak EJ, Mounier N, Imamura F, Merino J, Day FR, Zheng J, Taba N, Concas MP, Repetto L, Kentistou KA, Robino A, Esko T, Joshi PK, Fischer K, Ong KK, Gaunt TR, Kutalik Z, Perry JRB, Wilson JF

PLoS genetics Jun 2022

(DOI : 10.1371/journal.pgen.1010162)

Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study.

Heath AK, Muller DC, van den Brandt PA, Critselis E, Gunter M, Vineis P, Weiderpass E, Boeing H, Ferrari P, Merritt MA, Rostgaard-Hansen AL, Tjønneland A, Overvad K, Katzke V, Srour B, Masala G, Sacerdote C, Ricceri F, Pasanisi F, Bueno-de-Mesquita B, Downward GS, Skeie G, Sandanger TM, Crous-Bou M, Rodriguez-Barranco M, Amiano P, Huerta JM, Ardanaz E, Drake I, Johansson M, Johansson I, Key T, Papadimitriou N, Riboli E, Tzoulaki I, Tsilidis KK

International journal of cancer Jun 2022

(DOI : 10.1002/ijc.34211)

Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.

Jannasch F, Dietrich S, Bishop TRP, Pearce M, Fanidi A, O'Donoghue G, O'Gorman D, Marques-Vidal P, Vollenweider P, Bes-Rastrollo M, Byberg L, Wolk A, Hashemian M, Malekzadeh R, Poustchi H, Luft VC, de Matos SMA, Kim J, Kim MK, Kim Y, Stern D, Lajous M, Magliano DJ, Shaw JE, Akbaraly T, Kivimaki M, Maskarinec G, Le Marchand L, Martínez-González MÁ, Soedamah-Muthu SS, EPIC-InterAct Consortium EPIC-InterAct Consortium, Wareham NJ, Forouhi NG, Schulze MB

European journal of nutrition Jun 2022

(DOI : 10.1007/s00394-022-02909-9)

Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts.

Karavasiloglou N, Hughes DJ, Murphy N, Schomburg L, Sun Q, Seher V, Rohrmann S, Weiderpass E, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Mancini FR, Mahamat-Saleh Y, Kaaks R, Kühn T, Schulze MB, Tumino R, Panico S, Masala G, Pala V, Sacerdote C, Derksen JWG, Skeie G, Hjartåker A, Lasheras C, Agudo A, Sánchez MJ, Chirlaque MD, Ardanaz E, Amiano P, Van Guelpen B, Gylling B, Bradbury KE, Papier K, Freisling H, Aglago EK, Cross AJ, Riboli E, Aune D, Gunter MJ, Jenab M

The American Journal of Clinical Nutrition May 2022

(DOI : 10.1016/j.ajcnut.2022.10.004)

Artificial intelligence-enabled retinal vasculometry for prediction of circulatory mortality, myocardial infarction and stroke.

Rudnicka AR, Welikala R, Barman S, Foster PJ, Luben R, Hayat S, Khaw KT, Whincup P, Strachan D, Owen CG

The British journal of ophthalmology May 2022

(DOI : 10.1136/bjo-2022-321842)

The association between serum lipids and intraocular pressure in two large UK cohorts.

Madjedi KM, Stuart KV, Chua SYL, Luben RN, Warwick A, Pasquale LR, Kang JH, Wiggs JL, Lentjes MAH, Aschard H, Sattar N, Foster PJ, Khawaja AP, Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium Modifiable Risk Factors for Glaucoma Collaboration and the UK Biobank Eye and Vision Consortium

Ophthalmology Apr 2022

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Association of Accelerometer-Measured Sedentary Accumulation Patterns With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality.

Dempsey PC, Strain T, Winkler EAH, Westgate K, Rennie KL, Wareham NJ, Brage S, Wijndaele K

Journal of the American Heart Association Apr 2022

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The relationship between blood pressure and risk of renal cell carcinoma.

Alcala K, Mariosa D, Smith-Byrne K, Nasrollahzadeh Nesheli D, Carreras-Torres R, Ardanaz Aicua E, Bondonno NP, Bonet C, Brunström M, Bueno-de-Mesquita B, Chirlaque MD, Christakoudi S, Heath AK, Kaaks R, Katzke V, Krogh V, Ljungberg B, Martin RM, May A, Melander O, Palli D, Rodriguez-Barranco M, Sacerdote C, Stocks T, Tjønneland A, Travis RC, Vermeulen R, Chanock S, Purdue M, Weiderpass E, Muller D, Brennan P, Johansson M

International Journal of Epidemiology Mar 2022

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Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach.

Zamora-Ros R, Cayssials V, Clèries R, Torrents M, Byrnes G, Weiderpass E, Sandström M, Almquist M, Boutron-Ruault MC, Tjønneland A, Kyrø C, Katzke VA, Le Cornet C, Masala G, Krogh V, Iannuzzo G, Tumino R, Milani L, Skeie G, Ubago-Guisado E, Amiano P, Chirlaque MD, Ardanaz E, Janzi S, Eriksson L, Freisling H, Heath AK, Rinaldi S, Agudo A

European journal of nutrition Feb 2022

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Higher anticholinergic burden from medications is associated with significant increase in markers of inflammation in the EPIC-Norfolk prospective population-based cohort study.

Sanghavi R, Pana TA, Mamayusupova H, Maidment I, Fox C, Boekholdt SM, Mamas MA, Wareham NJ, Khaw KT, Myint PK

British journal of clinical pharmacology Jan 2022

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Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Lecuyer L, Laouali N, Dossus L, Shivappa N, Hébert JR, Agudo A, Tjonneland A, Halkjaer J, Overvad K, Katzke VA, Le Cornet C, Schulze MB, Jannasch F, Palli D, Agnoli C, Tumino R, Dragna L, Iannuzzo G, Jensen TE, Brustad M, Skeie G, Zamora-Ros R, Rodriguez-Barranco M, Amiano P, Chirlaque MD, Ardanaz E, Almquist M, Sonestedt E, Sandström M, Nilsson LM, Weiderpass E, Huybrechts I, Rinaldi S, Boutron-Ruault MC, Truong T

European journal of nutrition Jan 2022

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A longitudinal evaluation of alcohol intake throughout adulthood and colorectal cancer risk.

Mayén AL, Viallon V, Botteri E, Proust-Lima C, Bagnardi V, Batista V, Cross AJ, Laouali N, MacDonald CJ, Severi G, Katzke V, Bergmann MM, Schulze MB, Tjønneland A, Eriksen AK, Dahm CC, Antoniussen CS, Jakszyn P, Sánchez MJ, Amiano P, Colorado-Yohar SM, Ardanaz E, Travis R, Palli D, Sabina S, Tumino R, Ricceri F, Panico S, Bueno-de-Mesquita B, Derksen JWG, Sonestedt E, Winkvist A, Harlid S, Braaten T, Gram IT, Lukic M, Jenab M, Riboli E, Freisling H, Weiderpass E, Gunter MJ, Ferrari P

European Journal of Epidemiology Jan 2022

(DOI : 10.1007/s10654-022-00900-6)

Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention.

Li C, Imamura F, Wedekind R, Stewart ID, Pietzner M, Wheeler E, Forouhi NG, Langenberg C, Scalbert A, Wareham NJ

The American Journal of Clinical Nutrition Dec 2021

(DOI : 10.1093/ajcn/nqac094)

Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.

Nimptsch K, Aleksandrova K, Fedirko V, Jenab M, Gunter MJ, Siersema PD, Wu K, Katzke V, Kaaks R, Panico S, Palli D, May AM, Sieri S, Bueno-de-Mesquita B, Standahl K, Sánchez MJ, Perez-Cornago A, Olsen A, Tjønneland A, Bonet CB, Dahm CC, Chirlaque MD, Fiano V, Tumino R, Gurrea AB, Boutron-Ruault MC, Menegaux F, Severi G, Van Guelpen B, Lee YA, Pischon T

BMC cancer Dec 2021

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Face Validity of Observed Meal Patterns Reported with 7-Day Diet Diaries in a Large Population-Based Cohort Using Diurnal Variation in Concentration Biomarkers of Dietary Intake.

Lentjes MAH, Oude Griep LM, Mulligan AA, Montgomery S, Wareham NJ, Khaw KT

Nutrients Nov 2021

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Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries.

Steur M, Johnson L, Sharp SJ, Imamura F, Sluijs I, Key TJ, Wood A, Chowdhury R, Guevara M, Jakobsen MU, Johansson I, Koulman A, Overvad K, Sánchez MJ, van der Schouw YT, Trichopoulou A, Weiderpass E, Wennberg M, Zheng JS, Boeing H, Boer JMA, Boutron-Ruault MC, Ericson U, Heath AK, Huybrechts I, Imaz L, Kaaks R, Krogh V, Kühn T, Kyrø C, Masala G, Melander O, Moreno-Iribas C, Panico S, Quirós JR, Rodriguez-Barranco M, Sacerdote C, Santiuste C, Skeie G, Tjønneland A, Tumino R, Verschuren WMM, Zamora-Ros R, Dahm CC, Perez-Cornago A, Schulze MB, Tong TYN, Riboli E, Wareham NJ, Danesh J, Butterworth AS, Forouhi NG

Journal of the American Heart Association Nov 2021

(DOI : 10.1161/JAHA.120.019814)

Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study.

Fortuin-de Smidt MC, Sewe MO, Lassale C, Weiderpass E, Andersson J, Huerta JM, Ekelund U, Aleksandrova K, Tong TY, Dahm CC, Tjønneland A, Kyrø C, Steindorf K, Schulze MB, Katzke V, Sacerdote C, Agnoli C, Masala G, Tumino R, Panico S, Boer JM, Onland-Moret NC, Wendel-Vos GW, van der Schouw YT, Borch KB, Agudo A, Petrova D, Chirlaque MD, Conchi MI, Amiano P, Melander O, Heath AK, Aune D, Forouhi NG, Langenberg C, Brage S, Riboli E, Wareham NJ, Danesh J, Butterworth AS, Wennberg P

European Journal of Preventive Cardiology Nov 2021

(DOI : 10.1093/eurjpc/zwac055)

Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition.

Wedekind R, Rothwell JA, Viallon V, Keski-Rahkonen P, Schmidt JA, Chajès V, Katzke V, Johnson T, Santucci De Magistris M, Krogh V, Amiano P, Sacerdote C, Redondo-Sánchez D, Huerta JM, Tjønneland A, Pokharel P, Jakszyn P, Tumino R, Ardanaz E, Sandanger TM, Winkvist A, Hultdin J, Schulze MB, Weiderpass E, Gunter MJ, Huybrechts I, Scalbert A

Clinical nutrition (Edinburgh, Scotland) Nov 2021

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Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study.

Vissers LET, Sluijs I, Burgess S, Forouhi NG, Freisling H, Imamura F, Nilsson TK, Renstrom F, Weiderpass E, Aleksandrova K, Dahm CC, Perez-Cornago A, Schulze MB, Tong TYN, Aune D, Bonet C, Boer JMA, Boeing H, Chirlaque MD, Conchi MI, Imaz L, Jäger S, Krogh V, Kyrø C, Masala G, Melander O, Overvad K, Panico S, Sánches MJ, Sonestedt E, Tjønneland A, Tzoulaki I, Verschuren WMM, Riboli E, Wareham NJ, Danesh J, Butterworth AS, van der Schouw YT

The British journal of nutrition Oct 2021

(DOI : 10.1017/S0007114521004244)

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.

Nounu A, Richmond RC, Stewart ID, Surendran P, Wareham NJ, Butterworth A, Weinstein SJ, Albanes D, Baron JA, Hopper JL, Figueiredo JC, Newcomb PA, Lindor NM, Casey G, Platz EA, Marchand LL, Ulrich CM, Li CI, van Dujinhoven FJB, Gsur A, Campbell PT, Moreno V, Vodicka P, Vodickova L, Amitay E, Alwers E, Chang-Claude J, Sakoda LC, Slattery ML, Schoen RE, Gunter MJ, Castellví-Bel S, Kim HR, Kweon SS, Chan AT, Li L, Zheng W, Bishop DT, Buchanan DD, Giles GG, Gruber SB, Rennert G, Stadler ZK, Harrison TA, Lin Y, Keku TO, Woods MO, Schafmayer C, Van Guelpen B, Gallinger S, Hampel H, Berndt SI, Pharoah PDP, Lindblom A, Wolk A, Wu AH, White E, Peters U, Drew DA, Scherer D, Bermejo JL, Brenner H, Hoffmeister M, Williams AC, Relton CL

Nutrients Oct 2021

(DOI : 10.3390/nu13114164)

Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses.

Dimou N, Omiyale W, Biessy C, Viallon V, Kaaks R, O'Mara TA, Aglago EK, Ardanaz E, Bergmann MM, Bondonno NP, Braaten T, Colorado-Yohar SM, Crous-Bou M, Dahm CC, Fortner RT, Gram IT, Harlid S, Heath AK, Idahl A, Kvaskoff M, Nøst TH, Overvad K, Palli D, Perez-Cornago A, Sacerdote C, Sánchez MJ, Schulze MB, Severi G, Simeon V, Tagliabue G, Tjønneland A, Truong T, Tumino R, Johansson M, Weiderpass E, Murphy N, Gunter MJ, Lacey B, Allen NE, Dossus L

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Oct 2021

(DOI : 10.1158/1055-9965.EPI-21-1176)

Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex-specific and lifestyle factors specific associations.

Hua X, Labadie JD, Harrison TA, Dai JY, Lindström S, Lin Y, Berndt SI, Buchanan DD, Campbell PT, Casey G, Gallinger SJ, Gunter MJ, Hoffmeister M, Jenkins MA, Sakoda LC, Schoen RE, Diergaarde B, Slattery ML, White E, Giles G, Brenner H, Chang-Claude J, Joshi A, Ma W, Pai RK, Chan AT, Peters U, Newcomb PA