MRC Epidemiology Unit

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author => Wareham NJ
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Proteomic scores and dietary patterns.

Wareham NJ

Nature food Nov 2024

(DOI : 10.1038/s43016-024-01078-8)

Prediction of total and regional body composition from 3D body shape.

Qiao C, Rolfe EL, Mak E, Sengupta A, Powell R, Watson LPE, Heymsfield SB, Shepherd JA, Wareham N, Brage S, Cipolla R

NPJ digital medicine Oct 2024

(DOI : 10.1038/s41746-024-01289-0)

Combined associations of physical activity, diet quality and their changes over time with mortality: findings from the EPIC-Norfolk study, United Kingdom.

Aryannezhad S, Mok A, Imamura F, Wareham NJ, Brage S, Forouhi NG

BMC medicine Oct 2024

(DOI : 10.1186/s12916-024-03668-6)

Mapping biological influences on the human plasma proteome beyond the genome.

Carrasco-Zanini J, Wheeler E, Uluvar B, Kerrison N, Koprulu M, Wareham NJ, Pietzner M, Langenberg C

Nature metabolism Sep 2024

(DOI : 10.1038/s42255-024-01133-5)

Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.

Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S

Nature metabolism Sep 2024

(DOI : 10.1038/s42255-024-01126-4)

Systems Approach to Investigate the Role of Fruit and Vegetable Types on Vascular Function in Pre-Hypertensive Participants: Protocol and Baseline Characteristics of a Randomised Crossover Dietary Intervention.

Oude Griep LM, Frost G, Holmes E, Wareham NJ, Elliott P

Nutrients Sep 2024

(DOI : 10.3390/nu16172923)

Childhood-onset type 1 diabetes and subsequent adult psychiatric disorders: a nationwide cohort and genome-wide Mendelian randomization study.

Formánek T, Chen D, Šumník Z, Mladá K, Hughes J, Burgess S, Wareham NJ, Murray GK, Jones PB, Perry BI

Nature. Mental health Sep 2024

(DOI : PMC11383797)

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.

Willis TW, Gkrania-Klotsas E, Wareham NJ, McKinney EF, Lyons PA, Smith KGC, Wallace C

Clinical immunology (Orlando, Fla.) Sep 2024

(DOI : 10.1016/j.clim.2024.110356)

Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization.

Alwan H, Luan J, Williamson A, Carrasco-Zanini J, Stewart ID, Wareham NJ, Langenberg C, Pietzner M

EBioMedicine Aug 2024

(DOI : 10.1016/j.ebiom.2024.105306)

Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 1·97 million adults with 100 000 incident cases from 31 cohorts in 20 countries.

Li C, Bishop TRP, Imamura F, Sharp SJ, Pearce M, Brage S, Ong KK, Ahsan H, Bes-Rastrollo M, Beulens JWJ, den Braver N, Byberg L, Canhada S, Chen Z, Chung HF, Cortes-Valencia A, Djoussé L, Drouin-Chartier JP, Du H, Du S, Duncan BB, Gaziano JM, Gordon-Larsen P, Goto A, Haghighatdoost F, Härkänen T, Hashemian M, Hu FB, Ittermann T, Järvinen R, Kakkoura MG, Neelakantan N, Knekt P, Lajous M, Li Y, Magliano DJ, Malekzadeh R, Le Marchand L, Marques-Vidal P, Martínez-González MÁ, Maskarinec G, Mishra GD, Mohammadifard N, O'Donoghue G, O'Gorman D, Popkin B, Poustchi H, Sarrafzadegan N, Sawada N, Schmidt MI, Shaw JE, Soedamah-Muthu S, Stern D, Tong L, van Dam RM, Völzke H, Willett WC, Wolk A, Yu C, EPIC-InterAct Consortium EPIC-InterAct Consortium, Forouhi NG, Wareham NJ

The lancet. Diabetes & endocrinology Aug 2024

(DOI : 10.1016/S2213-8587(24)00179-7)

Trends in hospitalization for cardio-renal disease and mortality in people with type 1 diabetes in England, 2009-2019.

Holman N, Young B, Gregg EW, Wareham N, Sharp S, Khunti K, Sattar N, Valabhji J

Diabetes, obesity & metabolism Aug 2024

(DOI : 10.1111/dom.15783)

Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death.

Wang Y, Su B, Alcalde-Herraiz M, Barclay NL, Tian Y, Li C, Wareham NJ, Paredes R, Xie J, Prieto-Alhambra D

Nature communications Jul 2024

(DOI : 10.1038/s41467-024-50495-7)

Proteomic signatures improve risk prediction for common and rare diseases.

Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C, Grünschläger F, Fitzpatrick N, Ytsma C, Kanno T, Gade S, Freitag D, Ziebell F, Haas S, Denaxas S, Betts JC, Wareham NJ, Hemingway H, Scott RA, Langenberg C

Nature medicine Jul 2024

(DOI : 10.1038/s41591-024-03142-z)

Understanding the genetic complexity of puberty timing across the allele frequency spectrum.

Kentistou KA, Kaisinger LR, Stankovic S, Vaudel M, Mendes de Oliveira E, Messina A, Walters RG, Liu X, Busch AS, Helgason H, Thompson DJ, Santoni F, Petricek KM, Zouaghi Y, Huang-Doran I, Gudbjartsson DF, Bratland E, Lin K, Gardner EJ, Zhao Y, Jia RY, Terao C, Riggan MJ, Bolla MK, Yazdanpanah M, Yazdanpanah N, Bradfield JP, Broer L, Campbell A, Chasman DI, Cousminer DL, Franceschini N, Franke LH, Girotto G, He C, Järvelin MR, Joshi PK, Kamatani Y, Karlsson R, Luan J, Lunetta KL, Mägi R, Mangino M, Medland SE, Meisinger C, Noordam R, Nutile T, Concas MP, Polasek O, Porcu E, Ring SM, Sala C, Smith AV, Tanaka T, van der Most PJ, Vitart V, Wang CA, Willemsen G, Zygmunt M, Ahearn TU, Andrulis IL, Anton-Culver H, Antoniou AC, Auer PL, Barnes CLK, Beckmann MW, Berrington de González A, Bogdanova NV, Bojesen SE, Brenner H, Buring JE, Canzian F, Chang-Claude J, Couch FJ, Cox A, Crisponi L, Czene K, Daly MB, Demerath EW, Dennis J, Devilee P, De Vivo I, Dörk T, Dunning AM, Dwek M, Eriksson JG, Fasching PA, Fernández-Rhodes L, Ferreli L, Fletcher O, Gago-Dominguez M, García-Closas M, García-Sáenz JA, González-Neira A, Grallert H, Guénel P, Haiman CA, Hall P, Hamann U, Hakonarson H, Hart RJ, Hickey M, Hooning MJ, Hoppe R, Hopper JL, Hottenga JJ, Hu FB, Huebner H, Hunter DJ, ABCTB Investigators ABCTB Investigators, Jernström H, John EM, Karasik D, Khusnutdinova EK, Kristensen VN, Lacey JV, Lambrechts D, Launer LJ, Lind PA, Lindblom A, Magnusson PKE, Mannermaa A, McCarthy MI, Meitinger T, Menni C, Michailidou K, Millwood IY, Milne RL, Montgomery GW, Nevanlinna H, Nolte IM, Nyholt DR, Obi N, O'Brien KM, Offit K, Oldehinkel AJ, Ostrowski SR, Palotie A, Pedersen OB, Peters A, Pianigiani G, Plaseska-Karanfilska D, Pouta A, Pozarickij A, Radice P, Rennert G, Rosendaal FR, Ruggiero D, Saloustros E, Sandler DP, Schipf S, Schmidt CO, Schmidt MK, Small K, Spedicati B, Stampfer M, Stone J, Tamimi RM, Teras LR, Tikkanen E, Turman C, Vachon CM, Wang Q, Winqvist R, Wolk A, Zemel BS, Zheng W, van Dijk KW, Alizadeh BZ, Bandinelli S, Boerwinkle E, Boomsma DI, Ciullo M, Chenevix-Trench G, Cucca F, Esko T, Gieger C, Grant SFA, Gudnason V, Hayward C, Kolcic I, Kraft P, Lawlor DA, Martin NG, Nøhr EA, Pedersen NL, Pennell CE, Ridker PM, Robino A, Snieder H, Sovio U, Spector TD, Stöckl D, Sudlow C, Timpson NJ, Toniolo D, Uitterlinden A, Ulivi S, Völzke H, Wareham NJ, Widén E, Wilson JF, Lifelines Cohort Study Lifelines Cohort Study, Danish Blood Donor Study Danish Blood Donor Study, Ovarian Cancer Association Consortium Ovarian Cancer Association Consortium, Breast Cancer Association Consortium Breast Cancer Association Consortium, Biobank Japan Project Biobank Japan Project, China Kadoorie Biobank Collaborative Group China Kadoorie Biobank Collaborative Group, Pharoah PDP, Li L, Easton DF, Njølstad PR, Sulem P, Murabito JM, Murray A, Manousaki D, Juul A, Erikstrup C, Stefansson K, Horikoshi M, Chen Z, Farooqi IS, Pitteloud N, Johansson S, Day FR, Perry JRB, Ong KK

Nature genetics Jul 2024

(DOI : 10.1038/s41588-024-01798-4)

Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study.

Carrasco-Zanini J, Pietzner M, Koprulu M, Wheeler E, Kerrison ND, Wareham NJ, Langenberg C

The Lancet. Digital health Jun 2024

(DOI : 10.1016/S2589-7500(24)00087-6)

Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes.

Xie J, Mothe B, Alcalde Herraiz M, Li C, Xu Y, Jödicke AM, Gao Y, Wang Y, Feng S, Wei J, Chen Z, Hong S, Wu Y, Su B, Zheng X, Cohet C, Ali R, Wareham N, Alhambra DP

Nature communications May 2024

(DOI : 10.1038/s41467-024-48339-5)

Prediabetes, participation in the English National Health Service Diabetes Prevention Programme, and associations with COVID-19-related mortality: A whole population study.

Barron E, Sharp SJ, Khunti K, Bakhai C, Wareham NJ, Valabhji J

Diabetes Research and Clinical Practice May 2024

(DOI : 10.1016/j.diabres.2024.111692)

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.

Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E, Hellwege JN, Yengo L, Young WJ, Traylor M, Giri A, Zheng Z, Zeng J, Chasman DI, Morris AP, Caulfield MJ, Hwang SJ, Kooner JS, Conen D, Attia JR, Morrison AC, Loos RJF, Kristiansson K, Schmidt R, Hicks AA, Pramstaller PP, Nelson CP, Samani NJ, Risch L, Gyllensten U, Melander O, Riese H, Wilson JF, Campbell H, Rich SS, Psaty BM, Lu Y, Rotter JI, Guo X, Rice KM, Vollenweider P, Sundström J, Langenberg C, Tobin MD, Giedraitis V, Luan J, Tuomilehto J, Kutalik Z, Ripatti S, Salomaa V, Girotto G, Trompet S, Jukema JW, van der Harst P, Ridker PM, Giulianini F, Vitart V, Goel A, Watkins H, Harris SE, Deary IJ, van der Most PJ, Oldehinkel AJ, Keavney BD, Hayward C, Campbell A, Boehnke M, Scott LJ, Boutin T, Mamasoula C, Järvelin MR, Peters A, Gieger C, Lakatta EG, Cucca F, Hui J, Knekt P, Enroth S, de Borst MH, Polasek O, Concas MP, Catamo E, Cocca M, Li-Gao R, Hofer E, Schmidt H, Spedicati B, Waldenberger M, Strachan DP, Laan M, Teumer A, Dörr M, Gudnason V, Cook JP, Ruggiero D, Kolcic I, Boerwinkle E, Traglia M, Lehtimäki T, Raitakari OT, Johnson AD, Newton-Cheh C, Brown MJ, Dominiczak AF, Sever PJ, Poulter N, Chambers JC, Elosua R, Siscovick D, Esko T, Metspalu A, Strawbridge RJ, Laakso M, Hamsten A, Hottenga JJ, de Geus E, Morris AD, Palmer CNA, Nolte IM, Milaneschi Y, Marten J, Wright A, Zeggini E, Howson JMM, O'Donnell CJ, Spector T, Nalls MA, Simonsick EM, Liu Y, van Duijn CM, Butterworth AS, Danesh JN, Menni C, Wareham NJ, Khaw KT, Sun YV, Wilson PWF, Cho K, Visscher PM, Denny JC, Million Veteran Program Million Veteran Program, Lifelines Cohort Study Lifelines Cohort Study, CHARGE consortium CHARGE consortium, ICBP Consortium ICBP Consortium, Levy D, Edwards TL, Munroe PB, Snieder H, Warren HR

Nature genetics Apr 2024

(DOI : 10.1038/s41588-024-01714-w)

Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease.

Zhao Y, Chukanova M, Kentistou KA, Fairhurst-Hunter Z, Siegert AM, Jia RY, Dowsett GKC, Gardner EJ, Lawler K, Day FR, Kaisinger LR, Tung YL, Lam BYH, Chen HC, Wang Q, Berumen-Campos J, Kuri-Morales P, Tapia-Conyer R, Alegre-Diaz J, Barroso I, Emberson J, Torres JM, Collins R, Saleheen D, Smith KR, Paul DS, Merkle F, Farooqi IS, Wareham NJ, Petrovski S, O'Rahilly S, Ong KK, Yeo GSH, Perry JRB

Nature genetics Apr 2024

(DOI : 10.1038/s41588-024-01694-x)

A Self-Paced Walk Test for Individual Calibration of Heart Rate to Energy Expenditure

Westgate K, Gonzales TI, Hollidge S, Lindsay T, Wareham N, Brage S

Journal for the Measurement of Physical Behaviour Mar 2024

(DOI : 10.1123/jmpb.2023-0042)

Dementias Platform UK: Bringing genetics into life.

Leonenko G, Bauermeister S, Ghanti D, Stevenson-Hoare J, Simmonds E, Brookes K, Morgan K, Chaturvedi N, Elliott P, Thomas A, Wareham N, Gallacher J, Escott-Price V

Alzheimer's & dementia : the journal of the Alzheimer's Association Mar 2024

(DOI : 10.1002/alz.13782)

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.

Thériault S, Li Z, Abner E, Luan J, Manikpurage HD, Houessou U, Zamani P, Briend M, Estonian Biobank Research Team Estonian Biobank Research Team, Boudreau DK, Gaudreault N, Frenette L, Argaud D, Dahmene M, Dagenais F, Clavel MA, Pibarot P, Arsenault BJ, Boekholdt SM, Wareham NJ, Esko T, Mathieu P, Bossé Y

Nature communications Mar 2024

(DOI : 10.1038/s41467-024-46639-4)

Dietary intake of plant- and animal-derived protein and incident cardiovascular diseases: the pan-European EPIC-CVD case-cohort study.

Zheng JS, Steur M, Imamura F, Freisling H, Johnson L, van der Schouw YT, Tong TY, Weiderpass E, Bajracharya R, Crous-Bou M, Dahm CC, Heath AK, Ibsen DB, Jannasch F, Katzke V, Masala G, Moreno-Iribas C, Sacerdote C, Schulze MB, Sieri S, Wareham NJ, Danesh J, Butterworth AS, Forouhi NG

The American Journal of Clinical Nutrition Mar 2024

(DOI : 10.1016/j.ajcnut.2024.03.006)

Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.

Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Hakaste L, Han S, Hattersley AT, Herder C, Horikoshi M, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen T, Kamanu FK, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee KM, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Melander O, Metspalu A, Mo H, Morris AD, Moura FA, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schönherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stančáková A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yoon K, Yu C, Yuan JM, Yusuf S, Zawistowski M, Zhang L, Zheng W, VA Million Veteran Program VA Million Veteran Program, Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Fornage M, Hanis CL, Ingelsson E, Zonderman AB, Psaty BM, Wang YX, Rotimi CN, Becker DM, Matsuda F, Liu Y, Yokota M, Kardia SLR, Peyser PA, Pankow JS, Engert JC, Bonnefond A, Froguel P, Wilson JG, Sheu WHH, Wu JY, Hayes MG, Ma RCW, Wong TY, Mook-Kanamori DO, Tuomi T, Chandak GR, Collins FS, Bharadwaj D, Pare G, Sale MM, Ahsan H, Motala AA, Shu XO, Park KS, Jukema JW, Cruz M, Chen YI, Rich SS, McKean-Cowdin R, Grallert H, Cheng CY, Ghanbari M, Tai ES, Dupuis J, Kato N, Laakso M, Köttgen A, Koh WP, Bowden DW, Palmer CNA, Kooner JS, Kooperberg C, Liu S, North KE, Saleheen D, Hansen T, Pedersen O, Wareham NJ, Lee J, Kim BJ, Millwood IY, Walters RG, Stefansson K, Ahlqvist E, Goodarzi MO, Mohlke KL, Langenberg C, Haiman CA, Loos RJF, Florez JC, Rader DJ, Ritchie MD, Zöllner S, Mägi R, Marston NA, Ruff CT, van Heel DA, Finer S, Denny JC, Yamauchi T, Kadowaki T, Chambers JC, Ng MCY, Sim X, Below JE, Tsao PS, Chang KM, McCarthy MI, Meigs JB, Mahajan A, Spracklen CN, Mercader JM, Boehnke M, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E

Nature Feb 2024

(DOI : 10.1038/s41586-024-07019-6)

Relationship of fat mass ratio - a biomarker for lipodystrophy - with cardiometabolic traits.

Agrawal S, Luan J, Cummings BB, Weiss E, Wareham NJ, Khera AV

Diabetes Feb 2024

(DOI : 10.2337/db23-0575)

A meta-analysis of previous falls and subsequent fracture risk in cohort studies.

Vandenput L, Johansson H, McCloskey EV, Liu E, Schini M, Åkesson KE, Anderson FA, Azagra R, Bager CL, Beaudart C, Bischoff-Ferrari HA, Biver E, Bruyère O, Cauley JA, Center JR, Chapurlat R, Christiansen C, Cooper C, Crandall CJ, Cummings SR, da Silva JAP, Dawson-Hughes B, Diez-Perez A, Dufour AB, Eisman JA, Elders PJM, Ferrari S, Fujita Y, Fujiwara S, Glüer CC, Goldshtein I, Goltzman D, Gudnason V, Hall J, Hans D, Hoff M, Hollick RJ, Huisman M, Iki M, Ish-Shalom S, Jones G, Karlsson MK, Khosla S, Kiel DP, Koh WP, Koromani F, Kotowicz MA, Kröger H, Kwok T, Lamy O, Langhammer A, Larijani B, Lippuner K, McGuigan FEA, Mellström D, Merlijn T, Nguyen TV, Nordström A, Nordström P, O'Neill TW, Obermayer-Pietsch B, Ohlsson C, Orwoll ES, Pasco JA, Rivadeneira F, Schott AM, Shiroma EJ, Siggeirsdottir K, Simonsick EM, Sornay-Rendu E, Sund R, Swart KMA, Szulc P, Tamaki J, Torgerson DJ, van Schoor NM, van Staa TP, Vila J, Wareham NJ, Wright NC, Yoshimura N, Zillikens M, Zwart M, Harvey NC, Lorentzon M, Leslie WD, Kanis JA

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Jan 2024

(DOI : 10.1007/s00198-023-07012-1)

The relationship of within-individual and between-individual variation in mental health with bodyweight: An exploratory longitudinal study.

Mueller J, Ahern AL, Jones RA, Sharp SJ, Davies A, Zuckerman A, Perry BI, Khandaker GM, Rolfe EL, Wareham NJ, Rennie KL

PLoS ONE Jan 2024

(DOI : 10.1371/journal.pone.0295117)

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.

Watts EL, Gonzales TI, Strain T, Saint-Maurice PF, Bishop DT, Chanock SJ, Johansson M, Keku TO, Le Marchand L, Moreno V, Newcomb PA, Newton CC, Pai RK, Purdue MP, Ulrich CM, Smith-Byrne K, Van Guelpen B, PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS, Day FR, Wijndaele K, Wareham NJ, Matthews CE, Moore SC, Brage S

British journal of cancer Dec 2023

(DOI : 10.1038/s41416-023-02489-3)

Plasma Metabolites Related to the Consumption of Different Types of Dairy Products and Their Association with New-Onset Type 2 Diabetes: Analyses in the Fenland and EPIC-Norfolk Studies, United Kingdom.

Trichia E, Koulman A, Stewart ID, Brage S, Griffin SJ, Griffin JL, Khaw KT, Langenberg C, Wareham NJ, Imamura F, Forouhi NG

Molecular nutrition & food research Dec 2023

(DOI : 10.1002/mnfr.202300154)

Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study.

Pana TA, Mamas MA, Wareham NJ, Khaw KT, Dawson DK, Myint PK

European Journal of Preventive Cardiology Nov 2023

(DOI : 10.1093/eurjpc/zwad283)

Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study.

Teunis CJ, Stroes ESG, Boekholdt SM, Wareham NJ, Murphy AJ, Nieuwdorp M, Hazen SL, Hanssen NMJ

Atherosclerosis Nov 2023

(DOI : 10.1016/j.atherosclerosis.2023.117344)

Adherence to a healthy lifestyle, genetic susceptibility to abdominal obesity, cardiometabolic risk markers, and risk of coronary heart disease.

Wang M, Au Yeung SL, Luo S, Jang H, Ho HS, Sharp SJ, Wijndaele K, Brage S, Wareham NJ, Kim Y

The American Journal of Clinical Nutrition Nov 2023

(DOI : 10.1016/j.ajcnut.2023.08.002)

Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017-2018 and EPIC-Norfolk Cohorts.

Carr AC, Lunt H, Wareham NJ, Myint PK

Antioxidants (Basel, Switzerland) Oct 2023

(DOI : 10.3390/antiox12101863)

ANGPTL3 (Angiopoietin-Like 3) Preferentially Resides on High-Density Lipoprotein in the Human Circulation, Affecting Its Activity.

Kraaijenhof JM, Tromp TR, Nurmohamed NS, Reeskamp LF, Langenkamp M, Levels JHM, Boekholdt SM, Wareham NJ, Hoekstra M, Stroes ESG, Hovingh GK, Grefhorst A

Journal of the American Heart Association Oct 2023

(DOI : 10.1161/JAHA.123.030476)

Multi-omic prediction of incident type 2 diabetes.

Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ

Diabetologia Oct 2023

(DOI : 10.1007/s00125-023-06027-x)

The optimal healthy ranges of thyroid function defined by the risk of cardiovascular disease and mortality: systematic review and individual participant data meta-analysis.

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The lancet. Diabetes & endocrinology Sep 2023

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Nature genetics Sep 2023

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Journal of internal medicine Aug 2023

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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Aug 2023

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Genetic risk, adherence to healthy lifestyle and acute cardiovascular and thromboembolic complications following SARS-COV-2 infection.

Xie J, Feng Y, Newby D, Zheng B, Feng Q, Prats-Uribe A, Li C, Wareham NJ, Paredes R, Prieto-Alhambra D

Nature communications Aug 2023

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Nature communications Aug 2023

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Comment on Baranova et al. Causal Associations Between Basal Metabolic Rate and COVID-19. Diabetes 2023;72:149-154.

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Diabetes Jul 2023

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Molecular psychiatry Jul 2023

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Journal of the American College of Cardiology Jul 2023

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Causal associations between cardiorespiratory fitness and type 2 diabetes.

Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S, Wareham NJ

Nature communications Jul 2023

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Feasibility of using intermittent active monitoring of vital signs by smartphone users to predict SARS-CoV-2 PCR positivity.

Dolezalova N, Gkrania-Klotsas E, Morelli D, Moore A, Cunningham AC, Booth A, Plans D, Reed AB, Aral M, Rennie KL, Wareham NJ

Scientific reports Jun 2023

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Associations between change in physical activity and sedentary time and health-related quality of life in older english adults: the EPIC-Norfolk cohort study.

Yerrakalva D, Hajna S, Suhrcke M, Wijndaele K, Westgate K, Khaw KT, Wareham N, Brage S, Griffin S

Health and quality of life outcomes Jun 2023

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Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes: the EPIC-InterAct case-cohort study.

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Diabetologia Jun 2023

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Nature genetics Jun 2023

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Resting heart rate is a population-level biomarker of cardiorespiratory fitness: The Fenland Study.

Gonzales TI, Jeon JY, Lindsay T, Westgate K, Perez-Pozuelo I, Hollidge S, Wijndaele K, Rennie K, Forouhi N, Griffin S, Wareham N, Brage S

PLoS ONE May 2023

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Calcaneal broadband ultrasound attenuation predicts physical capability: EPIC-Norfolk prospective population-based study.

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Maturitas May 2023

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A nutritional biomarker score of the Mediterranean diet and incident type 2 diabetes: Integrated analysis of data from the MedLey randomised controlled trial and the EPIC-InterAct case-cohort study.

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PLoS Medicine Apr 2023

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Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization.

Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H, Kemp JP, Frysz M, Robinson J, Reppe S, Prijatelj V, Gautvik KM, Falk L, Maerz W, Gergei I, Peyser PA, Kavousi M, de Vries PS, Miller CL, Bos M, Van Der Laan SW, Malhotra R, Herrmann M, Scharnagl H, Kleber M, Dedoussis G, Zeggini E, Nethander M, Ohlsson C, Lorentzon M, Wareham N, Langenberg C, Holmes MV, Smith GD, Tobias JH

Arthritis & rheumatology (Hoboken, N.J.) Apr 2023

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Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.

Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ

European heart journal open Mar 2023

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The moderating role of eating behaviour traits in the association between exposure to hot food takeaway outlets and body fatness.

Hoenink JC, Burgoine T, Brage S, Forouhi N, Griffin SJ, Monsivais P, Wareham NJ, Ahern A, Adams J

International journal of obesity (2005) Mar 2023

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Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

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Nature Human Behaviour Mar 2023

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Proteogenomic links to human metabolic diseases.

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C

Nature metabolism Feb 2023

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Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.

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BMC cancer Feb 2023

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Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults.

Strain T, Dempsey PC, Wijndaele K, Sharp SJ, Kerrison N, Gonzales TI, Li C, Wheeler E, Langenberg C, Brage S, Wareham N

Diabetes care Jan 2023

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The association between plasma zinc concentrations and markers of glucose metabolism in adults in Cameroon.

Mba CM, Jones KS, Forouhi NG, Imamura F, Assah F, Mbanya JC, Wareham NJ

The British journal of nutrition Jan 2023

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Loci for insulin processing and secretion provide insight into type 2 diabetes risk.

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American journal of human genetics Jan 2023

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Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.

Kentistou KA, Luan J, Wittemans LBL, Hambly C, Klaric L, Kutalik Z, Speakman JR, Wareham NJ, Kendall TJ, Langenberg C, Wilson JF, Joshi PK, Morton NM

Nature communications Jan 2023

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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.

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Genome biology Dec 2022

(DOI : 10.1186/s13059-022-02837-1)

Damaging missense variants in implicate a role for IGF-1 resistance in the etiology of type 2 diabetes.

Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ, Langenberg C, O'Rahilly S, Ong KK, Perry JRB

Cell genomics Dec 2022

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Bidirectional associations of accelerometer-assessed physical activity and sedentary time with physical function among older English adults: the EPIC-Norfolk cohort study.

Yerrakalva D, Hajna S, Wijndaele K, Dempsey PC, Westgate K, Wareham N, Griffin SJ, Brage S

European journal of ageing Dec 2022

(DOI : 10.1007/s10433-022-00733-y)

Body Fat Percentage and the Long-term Risk of Fractures. The EPIC-Norfolk Prospective Population Cohort Study.

Pana TA, Kioh SH, Neal SR, Tan MP, Mat S, Moayyeri A, Luben RN, Wareham NJ, Khaw KT, Myint PK

Maturitas Dec 2022

(DOI : 10.1016/j.maturitas.2022.11.005)

Effectiveness of digital and remote provision of the Healthier You: NHS Diabetes Prevention Programme during the COVID-19 pandemic.

Barron E, Bradley D, Safazadeh S, McGough B, Bakhai C, Young B, Khunti K, Murray E, Wareham N, Jebb S, Valabhji J

Diabetic medicine : a journal of the British Diabetic Association Dec 2022

(DOI : 10.1111/dme.15028)

Longitudinal cardio-respiratory fitness prediction through wearables in free-living environments.

Spathis D, Perez-Pozuelo I, Gonzales TI, Wu Y, Brage S, Wareham N, Mascolo C

NPJ digital medicine Dec 2022

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Proteomic signatures for identification of impaired glucose tolerance.

Carrasco-Zanini J, Pietzner M, Lindbohm JV, Wheeler E, Oerton E, Kerrison N, Simpson M, Westacott M, Drolet D, Kivimaki M, Ostroff R, Williams SA, Wareham NJ, Langenberg C

Nature medicine Nov 2022

(DOI : 10.1038/s41591-022-02055-z)

Rare and common genetic determinants of metabolic individuality and their effects on human health.

Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF, Wittemans LBL, Bomba L, Menni C, Zierer J, Rossi N, Sheridan PA, Watkins NA, Mangino M, Hysi PG, Di Angelantonio E, Falchi M, Spector TD, Soranzo N, Michelotti GA, Arlt W, Lotta LA, Denaxas S, Hemingway H, Gamazon ER, Howson JMM, Wood AM, Danesh J, Wareham NJ, Kastenmüller G, Fauman EB, Suhre K, Butterworth AS, Langenberg C

Nature medicine Nov 2022

(DOI : 10.1038/s41591-022-02046-0)

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.

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Circulation Oct 2022

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Descriptive Epidemiology of Cardiorespiratory Fitness in UK Adults: The Fenland Study.

Gonzales TI, Westgate K, Hollidge S, Lindsay T, Wijndaele K, Forouhi NG, Griffin S, Wareham N, Brage S

Medicine and Science in Sports and Exercise Oct 2022

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A saturated map of common genetic variants associated with human height.

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Nature Oct 2022

(DOI : 10.1038/s41586-022-05275-y)

Engagement with mHealth COVID-19 digital biomarker measurements in a longitudinal cohort study: a mixed methods evaluation.

Rennie KL, Lawlor ER, Yassaee A, Booth A, Westgate K, Sharp SJ, Tyrrell CS, Aral M, Wareham NJ

Journal of medical Internet research Oct 2022

(DOI : 10.2196/40602)

An investigation of factors affecting changes in health behaviours during the COVID-19 pandemic in a UK population-based cohort study

Braithwaite VS, Sharp SJ, Koulman A, Wareham N, Rennie KL

Public Health Sep 2022

(DOI : 10.1016/j.puhe.2022.08.005)

Subclinical thyroid dysfunction and incident diabetes: a systematic review and an individual participant data analysis of prospective cohort studies.

Alwan H, Villoz F, Feller M, Dullaart RPF, Bakker SJL, Peeters RP, Kavousi M, Bauer DC, Cappola AR, Yeap BB, Walsh JP, Brown SJ, Ceresini G, Ferrucci L, Gussekloo J, Trompet S, Iacoviello M, Moon JH, Razvi S, Benseñor IM, Azizi F, Amouzegar A, Valdés S, Colomo N, Wareham NJ, Jukema JW, Westendorp RGJ, Kim KW, Rodondi N, Del Giovane C

European journal of endocrinology Sep 2022

(DOI : 10.1530/EJE-22-0523)

Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S, Ahluwalia TS, Bartz TM, Bentley AR, Bielak LF, Chong M, Chu AY, Berry D, Dorajoo R, Dueker ND, Kasbohm E, Feenstra B, Feitosa MF, Gieger C, Graff M, Hall LM, Haller T, Hartwig FP, Hillis DA, Huikari V, Heard-Costa N, Holzapfel C, Jackson AU, Johansson Å, Jørgensen AM, Kaakinen MA, Karlsson R, Kerr KF, Kim B, Koolhaas CM, Kutalik Z, Lagou V, Lind PA, Lorentzon M, Lyytikäinen LP, Mangino M, Metzendorf C, Monroe KR, Pacolet A, Pérusse L, Pool R, Richmond RC, Rivera NV, Robiou-du-Pont S, Schraut KE, Schulz CA, Stringham HM, Tanaka T, Teumer A, Turman C, van der Most PJ, Vanmunster M, van Rooij FJA, Van Vliet-Ostaptchouk JV, Zhang X, Zhao JH, Zhao W, Balkhiyarova Z, Balslev-Harder MN, Baumeister SE, Beilby J, Blangero J, Boomsma DI, Brage S, Braund PS, Brody JA, Bruinenberg M, Ekelund U, Liu CT, Cole JW, Collins FS, Cupples LA, Esko T, Enroth S, Faul JD, Fernández-Rhodes L, Fohner AE, Franco OH, Galesloot TE, Gordon SD, Grarup N, Hartman CA, Heiss G, Hui J, Illig T, Jago R, James A, Joshi PK, Jung T, Kähönen M, Kilpeläinen TO, Koh WP, Kolcic I, Kraft PP, Kuusisto J, Launer LJ, Li A, Linneberg A, Luan J, Vidal PM, Medland SE, Milaneschi Y, Moscati A, Musk B, Nelson CP, Nolte IM, Pedersen NL, Peters A, Peyser PA, Power C, Raitakari OT, Reedik M, Reiner AP, Ridker PM, Rudan I, Ryan K, Sarzynski MA, Scott LJ, Scott RA, Sidney S, Siggeirsdottir K, Smith AV, Smith JA, Sonestedt E, Strøm M, Tai ES, Teo KK, Thorand B, Tönjes A, Tremblay A, Uitterlinden AG, Vangipurapu J, van Schoor N, Völker U, Willemsen G, Williams K, Wong Q, Xu H, Young KL, Yuan JM, Zillikens MC, Zonderman AB, Ameur A, Bandinelli S, Bis JC, Boehnke M, Bouchard C, Chasman DI, Smith GD, de Geus EJC, Deldicque L, Dörr M, Evans MK, Ferrucci L, Fornage M, Fox C, Garland T, Gudnason V, Gyllensten U, Hansen T, Hayward C, Horta BL, Hyppönen E, Järvelin MR, Johnson WC, Kardia SLR, Kiemeney LA, Laakso M, Langenberg C, Lehtimäki T, Marchand LL, Lifelines Cohort Study Lifelines Cohort Study, Magnusson PKE, Martin NG, Melbye M, Metspalu A, Meyre D, North KE, Ohlsson C, Oldehinkel AJ, Orho-Melander M, Pare G, Park T, Pedersen O, Penninx BWJH, Pers TH, Polasek O, Prokopenko I, Rotimi CN, Samani NJ, Sim X, Snieder H, Sørensen TIA, Spector TD, Timpson NJ, van Dam RM, van der Velde N, van Duijn CM, Vollenweider P, Völzke H, Voortman T, Waeber G, Wareham NJ, Weir DR, Wichmann HE, Wilson JF, Hevener AL, Krook A, Zierath JR, Thomis MAI, Loos RJF, Hoed MD

Nature genetics Sep 2022

(DOI : 10.1038/s41588-022-01165-1)

Association between Legume Consumption and Risk of Hypertension in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Cohort.

Hartley M, Fyfe CL, Wareham NJ, Khaw KT, Johnstone AM, Myint PK

Nutrients Aug 2022

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