MRC Epidemiology Unit

 

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, Bretherick AD, Richardson TG, Klughammer J, Iotchkova V, Sharp G, Al Khleifat A, Shatunov A, Iacoangeli A, McArdle WL, Ho KM, Kumar A, Söderhäll C, Soriano-Tárraga C, Giralt-Steinhauer E, Kazmi N, Mason D, McRae AF, Corcoran DL, Sugden K, Kasela S, Cardona A, Day FR, Cugliari G, Viberti C, Guarrera S, Lerro M, Gupta R, Bollepalli S, Mandaviya P, Zeng Y, Clarke TK, Walker RM, Schmoll V, Czamara D, Ruiz-Arenas C, Rezwan FI, Marioni RE, Lin T, Awaloff Y, Germain M, Aïssi D, Zwamborn R, van Eijk K, Dekker A, van Dongen J, Hottenga JJ, Willemsen G, Xu CJ, Barturen G, Català-Moll F, Kerick M, Wang C, Melton P, Elliott HR, Shin J, Bernard M, Yet I, Smart M, Gorrie-Stone T, BIOS Consortium, Shaw C, Al Chalabi A, Ring SM, Pershagen G, Melén E, Jiménez-Conde J, Roquer J, Lawlor DA, Wright J, Martin NG, Montgomery GW, Moffitt TE, Poulton R, Esko T, Milani L, Metspalu A, Perry JRB, Ong KK, Wareham NJ, Matullo G, Sacerdote C, Panico S, Caspi A, Arseneault L, Gagnon F, Ollikainen M, Kaprio J, Felix JF, Rivadeneira F, Tiemeier H, van IJzendoorn MH, Uitterlinden AG, Jaddoe VWV, Haley C, McIntosh AM, Evans KL, Murray A, Räikkönen K, Lahti J, Nohr EA, Sørensen TIA, Hansen T, Morgen CS, Binder EB, Lucae S, González JR, Bustamante M, Sunyer J, Holloway JW, Karmaus W, Zhang H, Deary IJ, Wray NR, Starr JM, Beekman M, van Heemst D, Slagboom PE, Morange PE, Trégouët DA, Veldink JH, Davies GE, de Geus EJC, Boomsma DI, Vonk JM, Brunekreef B, Koppelman GH, Alarcón-Riquelme ME, Huang RC, Pennell CE, van Meurs J, Ikram MA, Hughes AD, Tillin T, Chaturvedi N, Pausova Z, Paus T, Spector TD, Kumari M, Schalkwyk LC, Visscher PM, Davey Smith G, Bock C, Gaunt TR, Bell JT, Heijmans BT, Mill J, Relton CL

Nature genetics. Oct 2020

(DOI : 10.1038/s41588-021-00923-x)

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The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies.

Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CB, Ben-Shlomo Y, Boerwinkle E, Casas JP, Clish C, Dale C, Dehghan A, Derkach A, Eliassen AH, Elliott P, Fahy E, Gieger C, Gunter MJ, Harada S, Harris T, Herr DR, Herrington D, Hirschhorn JN, Hoover E, Hsing AW, Johansson M, Kelly RS, Khoo CM, Kivimaki M, Kristal BS, Langenberg C, Lasky-Su J, Lawlor DA, Lotta LA, Mangino M, Le Marchand L, Mathé E, Matthews CE, Menni C, Mucci LA, Murphy R, Oresic M, Orwoll E, Ose J, Pereira AC, Playdon MC, Poston L, Price J, Qi Q, Rexrode K, Risch A, Sampson J, Seow WJ, Sesso HD, Shah SH, Shu XO, Smith GCS, Sovio U, Stevens VL, Stolzenberg-Solomon R, Takebayashi T, Tillin T, Travis R, Tzoulaki I, Ulrich CM, Vasan RS, Verma M, Wang Y, Wareham NJ, Wong A, Younes N, Zhao H, Zheng W, Moore SC

American Journal of Epidemiology. Sep 2018

(DOI : 10.1093/aje/kwz028)

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Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F, Stewart ID, Perry JR, Marney L, Koulman A, Karoly ED, Forouhi NG, Sjögren RJ, Näslund E, Zierath JR, Krook A, Savage DB, Griffin JL, Chaturvedi N, Hingorani AD, Khaw KT, Barroso I, McCarthy MI, O'Rahilly S, Wareham NJ, Langenberg C

PLoS Medicine. Aug 2016

(DOI : 10.1371/journal.pmed.1002179)

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Ethnic differences in cross-sectional associations between impaired glucose regulation, identified by oral glucose tolerance test or HbA1c values, and cardiovascular disease in a cohort of European and South Asian origin.

Eastwood SV, Tillin T, Mayet J, Shibata DK, Wright A, Heasman J, Beauchamp N, Forouhi NG, Hughes AD, Chaturvedi N

Diabetic medicine : a journal of the British Diabetic Association. Aug 2015

(DOI : 10.1111/dme.12895)

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Associations Between Prediabetes, by Three Different Diagnostic Criteria, and Incident CVD Differ in South Asians and Europeans.

Eastwood SV, Tillin T, Sattar N, Forouhi NG, Hughes AD, Chaturvedi N

Diabetes care. May 2015

(DOI : 10.2337/dc15-1078)

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Diabetes risk and amino acid profiles: cross-sectional and prospective analyses of ethnicity, amino acids and diabetes in a South Asian and European cohort from the SABRE (Southall And Brent REvisited) Study.

Tillin T, Hughes AD, Wang Q, Würtz P, Ala-Korpela M, Sattar N, Forouhi NG, Godsland IF, Eastwood SV, McKeigue PM, Chaturvedi N

Diabetologia. Nov 2014

(DOI : 10.1007/s00125-015-3517-8)

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Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.

Eastwood SV, Tillin T, Dehbi HM, Wright A, Forouhi NG, Godsland I, Whincup P, Sattar N, Hughes AD, Chaturvedi N

Obesity (Silver Spring, Md.). Sep 2014

(DOI : 10.1002/oby.20997)

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Ethnicity-specific obesity cut-points in the development of Type 2 diabetes - a prospective study including three ethnic groups in the United Kingdom.

Tillin T, Sattar N, Godsland IF, Hughes AD, Chaturvedi N, Forouhi NG

Diabetic medicine : a journal of the British Diabetic Association. Aug 2014

(DOI : 10.1111/dme.12576)

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The impact of health behaviours on incident cardiovascular disease in Europeans and South Asians--a prospective analysis in the UK SABRE study.

Eriksen A, Tillin T, O'Connor L, Brage S, Hughes A, Mayet J, McKeigue P, Whincup P, Chaturvedi N, Forouhi NG

PLoS ONE. Jun 2014

(DOI : 10.1371/journal.pone.0117364)

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Ethnicity and prediction of cardiovascular disease: performance of QRISK2 and Framingham scores in a U.K. tri-ethnic prospective cohort study (SABRE--Southall And Brent REvisited).

Tillin T, Hughes AD, Whincup P, Mayet J, Sattar N, McKeigue PM, Chaturvedi N, SABRE Study Group

Heart (British Cardiac Society). Nov 2013

(DOI : 10.1136/heartjnl-2013-304474)

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Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.

Eastwood SV, Tillin T, Wright A, Mayet J, Godsland I, Forouhi NG, Whincup P, Hughes AD, Chaturvedi N

Obesity (Silver Spring, Md.). Oct 2013

(DOI : 10.1002/oby.20796)

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Estimation of CT-derived abdominal visceral and subcutaneous adipose tissue depots from anthropometry in Europeans, South Asians and African Caribbeans.

Eastwood SV, Tillin T, Wright A, Heasman J, Willis J, Godsland IF, Forouhi N, Whincup P, Hughes AD, Chaturvedi N

PLoS ONE. May 2013

(DOI : 10.1371/journal.pone.0075085)

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Insulin resistance and truncal obesity as important determinants of the greater incidence of diabetes in Indian Asians and African Caribbeans compared with Europeans: the Southall And Brent REvisited (SABRE) cohort.

Tillin T, Hughes AD, Godsland IF, Whincup P, Forouhi NG, Welsh P, Sattar N, McKeigue PM, Chaturvedi N

Diabetes care. Sep 2012

(DOI : 10.2337/dc12-0544)

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The relationship between metabolic risk factors and incident cardiovascular disease in Europeans, South Asians, and African Caribbeans: SABRE (Southall and Brent Revisited) -- a prospective population-based study.

Tillin T, Hughes AD, Mayet J, Whincup P, Sattar N, Forouhi NG, McKeigue PM, Chaturvedi N

Journal of the American College of Cardiology. Jul 2012

(DOI : 10.1016/j.jacc.2012.12.046)

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Ethnic differences in disability prevalence and their determinants studied over a 20-year period: a cohort study.

Williams ED, Tillin T, Whincup P, Forouhi NG, Chaturvedi N

PLoS ONE. Jun 2012

(DOI : 10.1371/journal.pone.0045602)

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Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins.

Tillin T, Forouhi NG, McKeigue PM, Chaturvedi N

International Journal of Epidemiology. Nov 2010

(DOI : 10.1093/ije/dyq175)

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Cardiovascular disease mortality in relation to childhood and adulthood socioeconomic markers in British South Asian men.

Tillin T, Chaturvedi N, Forouhi NG, Smith GD, McKeigue PM

Heart (British Cardiac Society). Jul 2007

(DOI : 10.1136/hrt.2006.109165)

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Do known risk factors explain the higher coronary heart disease mortality in South Asian compared with European men? Prospective follow-up of the Southall and Brent studies, UK

Forouhi NG, Chaturvedi N, McKeigue PM, Sattar N, Tillin T

Diabetologia. Sep 2006

(DOI : 10.1007/s00125-006-0393-2)

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The role of diabetes and components of the metabolic syndrome in stroke and coronary heart disease mortality in U.K. white and African-Caribbean populations.

Tillin T, Forouhi NG, McKeigue PM, Chaturvedi N

Diabetes care. Aug 2006

(DOI : 10.2337/dc06-0779)

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