MRC Epidemiology Unit
Ekoru K, Murphy GAV, Young EH, Delisle H, Jerome CS, Assah F, Longo-Mbenza B, Nzambi JPD, On'Kin JBK, Buntix F, Muyer MC, Christensen DL, Wesseh CS, Sabir A, Okafor C, Gezawa ID, Puepet F, Enang O, Raimi T, Ohwovoriole E, Oladapo OO, Bovet P, Mollentze W, Unwin N, Gray WK, Walker R, Agoudavi K, Siziya S, Chifamba J, Njelekela M, Fourie CM, Kruger S, Schutte AE, Walsh C, Gareta D, Kamali A, Seeley J, Norris SA, Crowther NJ, Pillay D, Kaleebu P, Motala AA, Sandhu MS
International Journal of Obesity. Mar 2017
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Lipoprotein(a) Improves Cardiovascular Risk Prediction Based on Established Risk Algorithms.
Verbeek R, Sandhu MS, Hovingh GK, Sjouke B, Wareham NJ, Zwinderman AH, Kastelein JJP, Khaw KT, Tsimikas S, Boekholdt SM
Journal of the American College of Cardiology. Jun 2016
(DOI : 10.1016/j.jacc.2017.01.017)
The need for an integrated approach for chronic disease research and care in Africa.
Smeeth L, Wareham NJ, Rotimi CN, Mbanya JC, Sandhu MS
Global health, epidemiology and genomics. Feb 2016
(DOI : 10.1017/gheg.2016.16)
Verbeek R, Boekholdt SM, Stoekenbroek RM, Hovingh GK, Witztum JL, Wareham NJ, Sandhu MS, Khaw KT, Tsimikas S
Journal of lipid research. Jan 2016
(DOI : S0022-2275(20)35424-9)
Arsenault BJ, Boekholdt SM, Dubé MP, Rhéaume E, Wareham NJ, Khaw KT, Sandhu MS, Tardif JC
Circulation. Cardiovascular genetics. Apr 2014
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The association between circulating lipoprotein(a) and type 2 diabetes: is it causal?
Ye Zheng, Haycock PC, Gurdasani D, Pomilla C, Boekholdt SM, Tsimikas S, Khaw KT, Wareham NJ, Sandhu MS, Forouhi NG
Diabetes. Oct 2013
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Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.
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Journal of the American College of Cardiology. Apr 2013
(DOI : 10.1016/j.jacc.2013.06.044)
Common variants associated with plasma triglycerides and risk for coronary artery disease.
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Nature genetics. Feb 2013
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Common variants associated with plasma triglycerides and risk for coronary artery disease.
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Nature genetics. Feb 2013
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Gurdasani D, Sjouke B, Tsimikas S, Hovingh GK, Luben RN, Wainwright NW, Pomilla C, Wareham NJ, Khaw KT, Boekholdt SM, Sandhu MS
Arteriosclerosis, thrombosis, and vascular biology. Oct 2012
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Discovery and refinement of loci associated with lipid levels.
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Nature genetics. Oct 2012
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International journal of molecular epidemiology and genetics. Jun 2011
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Diabetes. Feb 2011
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Heart (British Cardiac Society). Oct 2010
(DOI : 10.1136/hrt.2010.210740)
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
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Arteriosclerosis, thrombosis, and vascular biology. Sep 2010
(DOI : 10.1161/ATVBAHA.109.201020)
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Diabetes. Sep 2010
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
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Nature genetics. Aug 2010
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Vergeer M, Boekholdt SM, Sandhu MS, Ricketts SL, Wareham NJ, Brown MJ, de Faire U, Leander K, Gigante B, Kavousi M, Hofman A, Uitterlinden AG, van Duijn CM, Witteman JC, Jukema JW, Schadt EE, van der Schoot E, Kastelein JJ, Khaw KT, Dullaart RP, van Tol A, Trip MD, Dallinga-Thie GM
Circulation. Jul 2010
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Casas JP, Ninio E, Panayiotou A, Palmen J, Cooper JA, Ricketts SL, Sofat R, Nicolaides AN, Corsetti JP, Fowkes FG, Tzoulaki I, Kumari M, Brunner EJ, Kivimaki M, Marmot MG, Hoffmann MM, Winkler K, März W, Ye S, Stirnadel HA, Boekholdt SM, Khaw KT, Humphries SE, Sandhu MS, Hingorani AD, Talmud PJ
Circulation. May 2010
(DOI : 10.1161/CIRCULATIONAHA.109.923383)
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
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Nature genetics. May 2010
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Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
Triglyceride Coronary Disease Genetics Consortium and Emerging Risk Factors Collaboration, Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Saleheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J
Lancet (London, England). May 2010
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van Wijk DF, van Leuven SI, Sandhu MS, Tanck MW, Hutten BA, Wareham NJ, Kastelein JJ, Stroes ES, Khaw KT, Boekholdt SM
Arteriosclerosis, thrombosis, and vascular biology. May 2010
(DOI : 10.1161/ATVBAHA.110.205526)
Telomere length in prospective and retrospective cancer case-control studies.
Pooley KA, Sandhu MS, Tyrer J, Shah M, Driver KE, Luben RN, Bingham SA, Ponder BA, Pharoah PD, Khaw KT, Easton DF, Dunning AM
Cancer research. Apr 2010
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Biological, clinical and population relevance of 95 loci for blood lipids.
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Nature. Feb 2010
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Diabetes. Dec 2009
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Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu MS, Ricketts SL, Boekholdt SM, Wareham NJ, Khaw KT, Kumari M, Kivimaki M, Marmot M, Asselbergs FW, van der Harst P, Dullaart RP, Navis G, van Veldhuisen DJ, van Gilst WH, Thompson JF, McCaskie P, Palmer LJ, Arca M, Quagliarini F, Gaudio C, Cambien F, Nicaud V, Poirer O, Gudnason V, Isaacs A, Witteman JC, van Duijn CM, Pencina M, Vasan RS, D'Agostino RB, Ordovas J, Li TY, Kakko S, Kauma H, Savolainen MJ, Kesaniemi YA, Sandhofer A, Paulweber B, Sorli JV, Goto A, Yokoyama S, Okumura K, Horne BD, Packard C, Freeman D, Ford I, Sattar N, McCormack V, Lawlor DA, Ebrahim S, Smith GD, Kastelein JJ, Deanfield J, Casas JP
Circulation. Dec 2009
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Journal of the American College of Cardiology. Nov 2009
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Vergeer M, Cohn DM, Boekholdt SM, Sandhu MS, Prins HM, Ricketts SL, Wareham NJ, Kastelein JJ, Khaw KT, Kamphuisen PW, Dallinga-Thie GM
Atherosclerosis. Sep 2009
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Rana JS, Cote M, Després JP, Sandhu MS, Talmud PJ, Ninio E, Wareham NJ, Kastelein JJ, Zwinderman AH, Khaw KT, Boekholdt SM
Heart (British Cardiac Society). Jul 2009
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PLoS ONE. May 2009
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PLoS genetics. Feb 2009
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Diabetologia. Nov 2008
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PLoS genetics. Sep 2008
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Nature genetics. Aug 2008
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The Journal of clinical endocrinology and metabolism. Jul 2008
(DOI : 10.1210/jc.2008-0366)
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O'Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N, Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Järvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN
Nature genetics. Jul 2008
(DOI : 10.1038/ng.287)
The ADRB3 Trp64Arg variant and BMI: a meta-analysis of 44 833 individuals.
Kurokawa N, Young EH, Oka Y, Satoh H, Wareham NJ, Sandhu MS, Loos RJ
International Journal of Obesity. Jun 2008
(DOI : 10.1038/ijo.2008.90)
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer.
Ito Y, Koessler T, Ibrahim AE, Rai S, Vowler SL, Abu-Amero S, Silva AL, Maia AT, Huddleston JE, Uribe-Lewis S, Woodfine K, Jagodic M, Nativio R, Dunning A, Moore G, Klenova E, Bingham S, Pharoah PD, Brenton JD, Beck S, Sandhu MS, Murrell A
Human Molecular Genetics. Jun 2008
(DOI : 10.1093/hmg/ddn163)
LDL-cholesterol concentrations: a genome-wide association study.
Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X, Johnson T, Ashford S, Inouye M, Luben R, Sims M, Hadley D, McArdle W, Barter P, Kesaniemi YA, Mahley RW, McPherson R, Grundy SM, Bingham SA, Khaw KT, Loos RJ, Waeber G, Barroso I, Strachan DP, Deloukas P, Vollenweider P, Wareham NJ, Mooser V
Lancet (London, England). Feb 2008
(DOI : 10.1016/S0140-6736(08)60208-1)
Mendelian randomisation studies of type 2 diabetes: future prospects.
Sandhu MS, Debenham SL, Barroso I, Loos RJ
Diabetologia. Dec 2007
(DOI : 10.1007/s00125-007-0903-x)
Energy intake at breakfast and weight change: prospective study of 6,764 middle-aged men and women.
Purslow LR, Sandhu MS, Forouhi N, Young EH, Luben RN, Welch AA, Khaw KT, Bingham SA, Wareham NJ
American Journal of Epidemiology. Dec 2007
(DOI : 10.1093/aje/kwm309)
Genome-wide association analysis identifies 20 loci that influence adult height.
Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JR, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CN, Morris AD, Ouwehand WH, Zhao JH, Li S, Loos RJ, Barroso I, Deloukas P, Sandhu MS, Wheeler E, Soranzo N, Inouye M, Wareham NJ, Caulfield M, Munroe PB, Hattersley AT, McCarthy MI, Frayling TM
Nature genetics. Nov 2007
(DOI : 10.1038/ng.121)
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Järvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M, Vogel CI, Wallace C, Waterworth DM, Weedon MN, Willer CJ, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstråle M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL
Nature genetics. Nov 2007
(DOI : 10.1038/ng.140)
Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL, Willer C, Olsson T, Wareham NJ, Hallmans G, Barroso I, Sandhu MS
Diabetologia. Aug 2007
(DOI : 10.1007/s00125-007-0887-6)
Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.
Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D, Knowler WC
Diabetologia. Aug 2007
(DOI : 10.1007/s00125-007-0891-x)
Purslow LR, Young EH, Wareham NJ, Forouhi N, Brunner EJ, Luben RN, Welch AA, Khaw KT, Bingham SA, Sandhu MS
BMC Public Health. Jul 2007
(DOI : 10.1186/1471-2458-8-112)
Heude B, Ong KK, Luben R, Wareham NJ, Sandhu MS
The Journal of clinical endocrinology and metabolism. May 2007
(DOI : 10.1210/jc.2006-1948)
van der Steeg WA, Boekholdt SM, Stein EA, El-Harchaoui K, Stroes ES, Sandhu MS, Wareham NJ, Jukema JW, Luben R, Zwinderman AH, Kastelein JJ, Khaw KT
Annals of internal medicine. May 2007
(DOI : 10.7326/0003-4819-146-9-200705010-00007)
Meirhaeghe A, Sandhu MS, McCarthy MI, de Groote P, Cottel D, Arveiler D, Ferrières J, Groves CJ, Hattersley AT, Hitman GA, Walker M, Wareham NJ, Amouyel P
Human Molecular Genetics. Apr 2007
(DOI : 10.1093/hmg/ddm084)
Young EH, Wareham NJ, Farooqi S, Hinney A, Hebebrand J, Scherag A, O'Rahilly S, Barroso I, Sandhu MS
International Journal of Obesity. Mar 2007
(DOI : 10.1038/sj.ijo.0803609)
Common variants in WFS1 confer risk of type 2 diabetes.
Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, Blech I, Pharoah PD, Palmer CN, Kimber C, Tavendale R, Morris AD, McCarthy MI, Walker M, Hitman G, Glaser B, Permutt MA, Hattersley AT, Wareham NJ, Barroso I
Nature genetics. Feb 2007
(DOI : 10.1038/ng2067)
Wareham NJ, Bingham SA, Boekholdt SM, Day NE, Khaw KT, Luben RN, Peters RJ, Sandhu MS
European Journal of Preventive Cardiology. Dec 2006
(DOI : 10.1097/01.hjr.0000209811.97948.07)
Forouhi NG, Harding AH, Allison M, Sandhu MS, Welch A, Luben R, Bingham S, Khaw KT, Wareham NJ
Diabetologia. Nov 2006
(DOI : 10.1007/s00125-007-0604-5)
PARL Leu262Val is not associated with fasting insulin levels in UK populations
Wareham NJ, Barroso I, Cooper C, Day NE, Luan J, O'Rahilly S, Sandhu MS, Fawcett KA, Syddall H
Diabetologia. Sep 2006
(DOI : 10.1007/s00125-006-0443-9)
Boekholdt SM, Sandhu MS, Wareham NJ, Luben R, Reitsma PH, Khaw KT
Journal of thrombosis and haemostasis : JTH. Aug 2006
(DOI : 10.1111/j.1538-7836.2006.02154.x)
Vaessen SF, Schaap FG, Kuivenhoven JA, Groen AK, Hutten BA, Boekholdt SM, Hattori H, Sandhu MS, Bingham SA, Luben R, Palmen JA, Wareham NJ, Humphries SE, Kastelein JJ, Talmud PJ, Khaw KT
Journal of lipid research. Jun 2006
(DOI : 10.1194/jlr.M600233-JLR200)
Surtees PG, Wainwright NW, Willis-Owen SA, Sandhu MS, Luben R, Day NE, Flint J
Journal of psychiatric research. Apr 2006
(DOI : 10.1016/j.jpsychires.2006.05.015)
Al-Zahrani A, Sandhu MS, Luben RN, Thompson D, Baynes C, Pooley KA, Luccarini C, Munday H, Perkins B, Smith P, Pharoah PD, Wareham NJ, Easton DF, Ponder BA, Dunning AM
Human Molecular Genetics. Nov 2005
(DOI : 10.1093/hmg/ddi398)
Surtees PG, Wainwright NW, Willis-Owen SA, Sandhu MS, Luben R, Day NE, Flint J
Journal of psychiatric research. Oct 2005
(DOI : 10.1016/j.jpsychires.2006.01.004)
Sandhu MS, Heude B, Young EH, Luben R, Luan J, Khaw KT, Todd J, Wareham NJ
Diabetes. Aug 2005
(DOI : 10.2337/diabetes.54.9.2812)
Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.
Barroso I, Luan J, Sandhu MS, Franks PW, Crowley V, Schafer AJ, O'Rahilly S, Wareham NJ
Diabetologia. Aug 2005
(DOI : 10.1007/s00125-005-0130-2)
Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, Peters RJ, Jukema JW, Day NE, Kastelein JJ, Khaw KT
Atherosclerosis. Apr 2005
(DOI : 10.1016/j.atherosclerosis.2005.09.023)
Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW, Kastelein JJ, Hack CE, Khaw KT
Arteriosclerosis, thrombosis, and vascular biology. Feb 2005
(DOI : 10.1161/01.ATV.0000157933.19424.b7)
Self-reported birth weight and subsequent risk of colorectal cancer.
Sandhu MS, Luben R, Day NE, Khaw KT
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. Sep 2002
Journal of Epidemiology and Community Health. Oct 2001
(DOI : 10.1136/jech.55.11.804)
Prevalence and family history of colorectal cancer: implications for screening.
Journal of medical screening. Aug 2001
(DOI : 10.1136/jms.8.2.69)
