MRC Epidemiology Unit

 

Tryptophan metabolites and incident cardiovascular disease: The EPIC-Norfolk prospective population study.

Teunis CJ, Stroes ESG, Boekholdt SM, Wareham NJ, Murphy AJ, Nieuwdorp M, Hazen SL, Hanssen NMJ

Atherosclerosis. Nov 2023

(DOI : 10.1016/j.atherosclerosis.2023.117344)

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ANGPTL3 (Angiopoietin-Like 3) Preferentially Resides on High-Density Lipoprotein in the Human Circulation, Affecting Its Activity.

Kraaijenhof JM, Tromp TR, Nurmohamed NS, Reeskamp LF, Langenkamp M, Levels JHM, Boekholdt SM, Wareham NJ, Hoekstra M, Stroes ESG, Hovingh GK, Grefhorst A

Journal of the American Heart Association. Oct 2023

(DOI : 10.1161/JAHA.123.030476)

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Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.

Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ

European heart journal open. Mar 2023

(DOI : 10.1093/ehjopen/oead032)

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Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.

Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ

Circulation. Genomic and precision medicine. Jul 2021

(DOI : 10.1161/CIRCGEN.120.003271)

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Impact of cholesterol on proinflammatory monocyte production by the bone marrow.

Stiekema LCA, Willemsen L, Kaiser Y, Prange KHM, Wareham NJ, Boekholdt SM, Kuijk C, de Winther MPJ, Voermans C, Nahrendorf M, Stroes ESG, Kroon J

European heart journal. Oct 2020

(DOI : 10.1093/eurheartj/ehab465)

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Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.

Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM

JAMA network open. Feb 2020

(DOI : 10.1001/jamanetworkopen.2020.0129)

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Improved cardiovascular risk prediction using targeted plasma proteomics in primary prevention.

Hoogeveen RM, Pereira JPB, Nurmohamed NS, Zampoleri V, Bom MJ, Baragetti A, Boekholdt SM, Knaapen P, Khaw KT, Wareham NJ, Groen AK, Catapano AL, Koenig W, Levin E, Stroes ESG

European heart journal. Nov 2019

(DOI : 10.1093/eurheartj/ehaa648)

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apoB/apoA-I Ratio and Lp(a) Associations With Aortic Valve Stenosis Incidence: Insights From the EPIC-Norfolk Prospective Population Study.

Zheng KH, Arsenault BJ, Kaiser Y, Khaw KT, Wareham NJ, Stroes ESG, Boekholdt SM

Journal of the American Heart Association. Aug 2019

(DOI : 10.1161/JAHA.119.013020)

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Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study.

van Capelleveen JC, Lee SR, Verbeek R, Kastelein JJP, Wareham NJ, Stroes ESG, Hovingh GK, Khaw KT, Boekholdt SM, Witztum JL, Tsimikas S

Journal of clinical lipidology. Mar 2018

(DOI : 10.1016/j.jacl.2018.08.010)

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A 3-SNP gene risk score and a metabolic risk score both predict hypertriglyceridemia and cardiovascular disease risk.

Verbeek R, Oldoni F, Surendran RP, Zwinderman AH, Khaw KT, Stroes ESG, Wareham NJ, Boekholdt SM, Dallinga-Thie GM

Journal of clinical lipidology. Jan 2018

(DOI : 10.1016/j.jacl.2019.02.005)

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Effect of Long-Term Low Lipoproteins on Neurocognitive Function.

Verbeek R, Boekholdt SM, Luben R, Stroes ESG, Khaw KT, Hovingh GK

Journal of the American College of Cardiology. Nov 2017

(DOI : 10.1016/j.jacc.2018.06.043)

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Cardiovascular disease risk associated with elevated lipoprotein(a) attenuates at low low-density lipoprotein cholesterol levels in a primary prevention setting.

Verbeek R, Hoogeveen RM, Langsted A, Stiekema LCA, Verweij SL, Hovingh GK, Wareham NJ, Khaw KT, Boekholdt SM, Nordestgaard BG, Stroes ESG

European heart journal. Oct 2017

(DOI : 10.1093/eurheartj/ehy334)

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Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study.

van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum JL, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S

Arteriosclerosis, thrombosis, and vascular biology. Jan 2017

(DOI : 10.1161/ATVBAHA.117.309007)

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