MRC Epidemiology Unit

 

Association of insulin resistance with the accumulation of saturated intramyocellular lipid: A comparison with other fat stores.

Azhar M, Watson LPE, De Lucia Rolfe E, Ferraro M, Carr K, Worsley J, Boesch C, Hodson L, Chatterjee KK, Kemp GJ, Savage DB, Sleigh A

NMR in biomedicine. Feb 2024

(DOI : 10.1002/nbm.5117)

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Accumulation of saturated intramyocellular lipid is associated with insulin resistance.

Savage DB, Watson L, Carr K, Adams C, Brage S, Chatterjee KK, Hodson L, Boesch C, Kemp GJ, Sleigh A

Journal of lipid research. Dec 2018

(DOI : 10.1194/jlr.M091942)

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Validity of ultrasonography to assess hepatic steatosis compared to magnetic resonance spectroscopy as a criterion method in older adults.

De Lucia Rolfe E, Brage S, Sleigh A, Finucane F, Griffin SJ, Wareham NJ, Ong KK, Forouhi NG

PLoS ONE. Apr 2018

(DOI : 10.1371/journal.pone.0207923)

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Validity of visceral adiposity estimates from DXA against MRI in Kuwaiti men and women.

Mohammad A, De Lucia Rolfe E, Sleigh A, Kivisild T, Behbehani K, Wareham NJ, Brage S, Mohammad T

Nutrition & diabetes. Jan 2016

(DOI : 10.1038/nutd.2016.38)

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Abdominal fat depots associated with insulin resistance and metabolic syndrome risk factors in black African young adults.

De Lucia Rolfe E, Ong KK, Sleigh A, Dunger DB, Norris SA

BMC Public Health. Jun 2015

(DOI : 10.1186/s12889-015-2147-x)

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Defective mitochondrial function in vivo in skeletal muscle in adults with Down's syndrome: a 31P-MRS study.

Phillips AC, Sleigh A, McAllister CJ, Brage S, Carpenter TA, Kemp GJ, Holland AJ

PLoS ONE. Jul 2013

(DOI : 10.1371/journal.pone.0084031)

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Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals.

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Aihie Sayer A, Cooper C, Griffin SJ, Wareham NJ

Diabetology & metabolic syndrome. Jul 2013

(DOI : 10.1186/1758-5996-6-43)

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Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Older Individuals.

Finucane FM, Sharp SJ, Hatunic M, Sleigh A, De Lucia Rolfe E, Sayer AA, Cooper C, Griffin SJ, Savage DB, Wareham NJ

International journal of endocrinology. Jan 2013

(DOI : 10.1155/2013/870487)

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Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.

Sleigh A, Stears A, Thackray K, Watson L, Gambineri A, Nag S, Campi VI, Schoenmakers N, Brage S, Carpenter TA, Murgatroyd PR, O'Rahilly S, Kemp GJ, Savage DB

The Journal of clinical endocrinology and metabolism. Jan 2012

(DOI : 10.1210/jc.2011-2587)

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Validation of ultrasound estimates of visceral fat in black South African adolescents.

De Lucia Rolfe E, Norris SA, Sleigh A, Brage S, Dunger DB, Stolk RP, Ong KK

Obesity (Silver Spring, Md.). Jul 2011

(DOI : 10.1038/oby.2011.213)

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Mitochondrial dysfunction in patients with primary congenital insulin resistance.

Sleigh A, Raymond-Barker P, Thackray K, Porter D, Hatunic M, Vottero A, Burren C, Mitchell C, McIntyre M, Brage S, Carpenter TA, Murgatroyd PR, Brindle KM, Kemp GJ, O'Rahilly S, Semple RK, Savage DB

The Journal of clinical investigation. Jan 2011

(DOI : 10.1172/JCI46405)

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Computed tomography-based validation of abdominal adiposity measurements from ultrasonography, dual-energy X-ray absorptiometry and anthropometry.

Gradmark AM, Rydh A, Renstrom F, De Lucia Rolfe E, Sleigh A, Nordström P, Brage S, Franks PW

The British journal of nutrition. Apr 2010

(DOI : 10.1017/S0007114510000796)

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Ultrasound measurements of visceral and subcutaneous abdominal thickness to predict abdominal adiposity among older men and women.

De Lucia Rolfe E, Sleigh A, Finucane FM, Brage S, Stolk RP, Cooper C, Sharp SJ, Wareham NJ, Ong KK

Obesity (Silver Spring, Md.). Sep 2009

(DOI : 10.1038/oby.2009.309)

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The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial.

Finucane FM, Sharp SJ, Purslow LR, Horton K, Horton J, Savage DB, Brage S, Besson H, De Lucia Rolfe E, Sleigh A, Martin HJ, Aihie Sayer A, Cooper C, Ekelund U, Griffin SJ, Wareham NJ

Diabetologia. Aug 2009

(DOI : 10.1007/s00125-009-1641-z)

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Randomized controlled trial of the efficacy of aerobic exercise in reducing metabolic risk in healthy older people: The Hertfordshire Physical Activity Trial.

Finucane FM, Horton J, Purslow LR, Savage DB, Brage S, Besson H, Horton K, Rolfe Ede L, Sleigh A, Sharp SJ, Martin HJ, Sayer AA, Cooper C, Ekelund U, Griffin SJ, Wareham NJ

BMC endocrine disorders. Mar 2009

(DOI : 10.1186/1472-6823-9-15)

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