MRC Epidemiology Unit

 

Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.

Thériault S, Li Z, Abner E, Luan J, Manikpurage HD, Houessou U, Zamani P, Briend M, Estonian Biobank Research Team Estonian Biobank Research Team, Boudreau DK, Gaudreault N, Frenette L, Argaud D, Dahmene M, Dagenais F, Clavel MA, Pibarot P, Arsenault BJ, Boekholdt SM, Wareham NJ, Esko T, Mathieu P, Bossé Y

Nature communications. Mar 2024

(DOI : 10.1038/s41467-024-46639-4)

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Impact of C-reactive protein levels on lipoprotein(a)-associated aortic stenosis incidence and progression.

Girard A, Gaillard E, Puri R, Capoulade R, Chan KL, Paulin A, Manikpurage HD, Dumesnil J, Tam JW, Teo KK, Couture C, Wareham NJ, Clavel MA, Stroes ESG, Mathieu P, Thériault S, Tsimikas S, Pibarot P, Boekholdt SM, Arsenault BJ

European heart journal open. Mar 2023

(DOI : 10.1093/ehjopen/oead032)

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Sex-Specific Associations of Genetically Predicted Circulating Lp(a) (Lipoprotein(a)) and Hepatic Gene Expression Levels With Cardiovascular Outcomes: Mendelian Randomization and Observational Analyses.

Guertin J, Kaiser Y, Manikpurage H, Perrot N, Bourgeois R, Couture C, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Clavel MA, Thériault S, Boekholdt SM, Arsenault BJ

Circulation. Genomic and precision medicine. Jul 2021

(DOI : 10.1161/CIRCGEN.120.003271)

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Genetic Variation in LPA, Calcific Aortic Valve Stenosis in Patients Undergoing Cardiac Surgery, and Familial Risk of Aortic Valve Microcalcification.

Perrot N, Thériault S, Dina C, Chen HY, Boekholdt SM, Rigade S, Després AA, Poulin A, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Khaw KT, Wareham NJ, Dweck MR, Mathieu P, Pibarot P, Schott JJ, Thanassoulis G, Clavel MA, Bossé Y, Arsenault BJ

JAMA cardiology. May 2020

(DOI : 10.1001/jamacardio.2019.1581)

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Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis.

Chen HY, Cairns BJ, Small AM, Burr HA, Ambikkumar A, Martinsson A, Thériault S, Munter HM, Steffen B, Zhang R, Levinson RT, Shaffer CM, Rong J, Sonestedt E, Dufresne L, Ljungberg J, Näslund U, Johansson B, Ranatunga DK, Whitmer RA, Budoff MJ, Nguyen A, Vasan RS, Larson MG, Harris WS, Damrauer SM, Stark KD, Boekholdt SM, Wareham NJ, Pibarot P, Arsenault BJ, Mathieu P, Gudnason V, O'Donnell CJ, Rotter JI, Tsai MY, Post WS, Clarke R, Söderberg S, Bossé Y, Wells QS, Smith JG, Rader DJ, Lathrop M, Engert JC, Thanassoulis G

JAMA cardiology. Mar 2020

(DOI : 10.1001/jamacardio.2020.0246)

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Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis.

Arsenault BJ, Pelletier W, Kaiser Y, Perrot N, Couture C, Khaw KT, Wareham NJ, Bossé Y, Pibarot P, Stroes ESG, Mathieu P, Thériault S, Boekholdt SM

JAMA network open. Feb 2020

(DOI : 10.1001/jamanetworkopen.2020.0129)

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Lipoprotein-associated phospholipase A2 activity, genetics and calcific aortic valve stenosis in humans.

Perrot N, Thériault S, Rigade S, Chen HY, Dina C, Martinsson A, Boekholdt SM, Capoulade R, Le Tourneau T, Messika-Zeitoun D, Engert JC, Wareham NJ, Clavel MA, Pibarot P, Smith JG, Schott JJ, Mathieu P, Bossé Y, Thanassoulis G, Arsenault BJ

Heart (British Cardiac Society). Feb 2020

(DOI : 10.1136/heartjnl-2020-316722)

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apoB/apoA-I Ratio and Lp(a) Associations With Aortic Valve Stenosis Incidence: Insights From the EPIC-Norfolk Prospective Population Study.

Zheng KH, Arsenault BJ, Kaiser Y, Khaw KT, Wareham NJ, Stroes ESG, Boekholdt SM

Journal of the American Heart Association. Aug 2019

(DOI : 10.1161/JAHA.119.013020)

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Life's simple 7 and calcific aortic valve stenosis incidence in apparently healthy men and women.

Perrot N, Boekholdt SM, Mathieu P, Wareham NJ, Khaw KT, Arsenault BJ

International journal of cardiology. Jan 2018

(DOI : 10.1016/j.ijcard.2018.07.107)

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Ideal cardiovascular health influences cardiovascular disease risk associated with high lipoprotein(a) levels and genotype: The EPIC-Norfolk prospective population study.

Perrot N, Verbeek R, Sandhu M, Boekholdt SM, Hovingh GK, Wareham NJ, Khaw KT, Arsenault BJ

Atherosclerosis. Jul 2016

(DOI : 10.1016/j.atherosclerosis.2016.11.010)

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Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.

Verbeek R, Boyer M, Boekholdt SM, Hovingh GK, Kastelein JJ, Wareham N, Khaw KT, Arsenault BJ

Arteriosclerosis, thrombosis, and vascular biology. Jun 2016

(DOI : 10.1161/ATVBAHA.116.307995)

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C-Reactive Protein Identifies Low-Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer-Norfolk Prospective Population Study.

van Wijk DF, Boekholdt SM, Arsenault BJ, Ahmadi-Abhari S, Wareham NJ, Stroes ES, Khaw KT

Journal of the American Heart Association. Jun 2016

(DOI : 10.1161/JAHA.115.002823)

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Impact of abdominal obesity and systemic hypertension on risk of coronary heart disease in men and women: the EPIC-Norfolk Population Study.

Rhéaume C, Arsenault BJ, Després JP, Faha, Boekholdt SM, Wareham NJ, Khaw KT, Chir M

Journal of hypertension. Aug 2014

(DOI : 10.1097/HJH.0000000000000307)

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Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective Mendelian randomization study and replication in a case-control cohort.

Arsenault BJ, Boekholdt SM, Dubé MP, Rhéaume E, Wareham NJ, Khaw KT, Sandhu MS, Tardif JC

Circulation. Cardiovascular genetics. Apr 2014

(DOI : 10.1161/CIRCGENETICS.113.000400)

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Non-HDL cholesterol vs. apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study.

Sondermeijer BM, Rana JS, Arsenault BJ, Shah PK, Kastelein JJ, Wareham NJ, Boekholdt SM, Khaw KT

European journal of clinical investigation. Aug 2012

(DOI : 10.1111/eci.12129)

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Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study.

Broekhuizen LN, Boekholdt SM, Arsenault BJ, Després JP, Stroes ES, Kastelein JJ, Khaw KT, Wareham NJ

European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. Apr 2011

(DOI : 10.1177/1741826710389397)

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Adiponectin and risk of coronary heart disease in apparently healthy men and women (from the EPIC-Norfolk Prospective Population Study).

Cote M, Cartier A, Reuwer AQ, Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Kastelein JJ, Boekholdt SM, Khaw KT

The American journal of cardiology. Jan 2011

(DOI : 10.1016/j.amjcard.2011.03.053)

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Lipid assessment, metabolic syndrome and coronary heart disease risk.

Arsenault BJ, Després JP, Stroes ES, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM

European journal of clinical investigation. Aug 2010

(DOI : 10.1111/j.1365-2362.2010.02357.x)

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The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk prospective population study.

Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. Jul 2010

(DOI : 10.1503/cmaj.091276)

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Comparison between gradient gel electrophoresis and nuclear magnetic resonance spectroscopy in estimating coronary heart disease risk associated with LDL and HDL particle size.

Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Stroes ES, Kastelein JJ, Khaw KT, Boekholdt SM

Clinical chemistry. Mar 2010

(DOI : 10.1373/clinchem.2009.140939)

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Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women.

Arsenault BJ, Rana JS, Lemieux I, Després JP, Kastelein JJ, Boekholdt SM, Wareham NJ, Khaw KT

International Journal of Obesity. Nov 2009

(DOI : 10.1038/ijo.2009.229)

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Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study.

Arsenault BJ, Rana JS, Lemieux I, Després JP, Wareham NJ, Kastelein JJ, Boekholdt SM, Khaw KT

Atherosclerosis. Jul 2009

(DOI : 10.1016/j.atherosclerosis.2009.08.048)

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Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women.

Arsenault BJ, Rana JS, Stroes ES, Després JP, Shah PK, Kastelein JJ, Wareham NJ, Boekholdt SM, Khaw KT

Journal of the American College of Cardiology. Apr 2009

(DOI : 10.1016/j.jacc.2009.07.057)

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Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women.

Rana JS, Arsenault BJ, Després JP, Cote M, Talmud PJ, Ninio E, Wouter Jukema J, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM

European heart journal. Feb 2009

(DOI : 10.1093/eurheartj/ehp010)

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High-density lipoprotein particle size and concentration and coronary risk.

El Harchaoui K, Arsenault BJ, Franssen R, Després JP, Hovingh GK, Stroes ES, Otvos JD, Wareham NJ, Kastelein JJ, Khaw KT, Boekholdt SM

Annals of internal medicine. Jan 2009

(DOI : 10.7326/0003-4819-150-2-200901200-00006)

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Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Rana JS, Visser ME, Arsenault BJ, Després JP, Stroes ES, Kastelein JJ, Wareham NJ, Boekholdt SM, Khaw KT

International journal of cardiology. Sep 2008

(DOI : 10.1016/j.ijcard.2009.03.123)

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HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study.

Arsenault BJ, Lemieux I, Després JP, Gagnon P, Wareham NJ, Stroes ES, Kastelein JJ, Khaw KT, Boekholdt SM

Atherosclerosis. Aug 2008

(DOI : 10.1016/j.atherosclerosis.2009.01.044)

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Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study.

Arsenault BJ, Lemieux I, Després JP, Wareham NJ, Luben R, Kastelein JJ, Khaw KT, Boekholdt SM

European heart journal. Oct 2007

(DOI : 10.1093/eurheartj/ehm390)

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