MRC Epidemiology Unit

 

Bidirectional Mendelian Randomization Indicates Causal Relationships Between Circulating Branched-Chain Amino Acids and Metabolic Health.

Jia RY, Kentistou KA, Zhao Y, Gardner EJ, Perry JRB, O'Rahilly S, Day FR, Ong KK, Ong K, Day F, Perry JR, Jia R, Kentistou K, Gardner E

Diabetes. Jan 2025

(DOI : 10.2337/db24-1162)

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Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health.

Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J, Collins A, Romartínez-Alonso B, Tadross JA, Jia R, Gardner EJ, Kentistou K, Zhao Y, Day F, Mörseburg A, Rainbow K, Rimmington D, Mastantuoni M, Harrison J, Nus M, Guma'a K, Sherratt-Mayhew S, Jiang X, Smith KR, Paul DS, Jenkins B, Koulman A, Pietzner M, Langenberg C, Wareham N, Yeo GS, Chatterjee K, Schwabe J, Oakley F, Mann DA, Tontonoz P, Coll AP, Ong K, Perry JRB, O'Rahilly S

Nature metabolism. Sep 2024

(DOI : 10.1038/s42255-024-01126-4)

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