MRC Epidemiology Unit - Publications Database

Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health.

Zhao Y, Lockhart S, Liu J, Li X, Cortes A, Hua X, Gardner EJ, Kentistou KA, Cañadas-Garre M, Fabian L, Ho K, Timpson N, Lo Y, Davitte J, Savage DB, Buser-Doepner C, Ong KK, Zhang H, Scott R, O'Rahilly S, Perry JRB

Nature genetics. Oct 2025

(DOI : 10.1038/s41588-025-02364-2)

Effects of rare coding variants in severe early-onset obesity genes in the population-based UK Biobank study.

Jia RY, Lockhart S, Lam BYH, Zhao Y, Kentistou KA, Gardner EJ, Farooqi IS, O'Rahilly S, Day FR, Ong KK, Perry JRB, Ong K, Perry JR, Kentistou K

The Journal of clinical endocrinology and metabolism. Oct 2024

(DOI : 10.1210/clinem/dgaf132)

Proteogenomic links to human metabolic diseases.

Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C

Nature metabolism. Feb 2023

(DOI : 10.1038/s42255-023-00753-7)

Damaging missense variants in implicate a role for IGF-1 resistance in the etiology of type 2 diabetes.

Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ, Langenberg C, O'Rahilly S, Ong KK, Perry JRB

Cell genomics. Dec 2022

(DOI : 10.1016/j.xgen.2022.100208)