Genetic links between ovarian ageing, cancer risk and de novo mutation rates.
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Nature. Sep 2024
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Loss of transient receptor potential channel 5 causes obesity and postpartum depression.
Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS
Cell. Jul 2024
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Understanding the genetic complexity of puberty timing across the allele frequency spectrum.
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Nature genetics. Jul 2024
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Genetic drivers and cellular selection of female mosaic X chromosome loss.
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Nature. Jun 2024
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Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation.
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Cell metabolism. Apr 2024
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Nature genetics. Apr 2024
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Saturation genome editing of DDX3X clarifies pathogenicity of germline and somatic variation.
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Nature communications. Dec 2023
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Shared and distinct genetic etiologies for different types of clonal hematopoiesis.
Brown DW, Cato LD, Zhao Y, Nandakumar SK, Bao EL, Gardner EJ, Hubbard AK, DePaulis A, Rehling T, Song L, Yu K, Chanock SJ, Perry JRB, Sankaran VG, Machiela MJ
Nature communications. Sep 2023
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Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.
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Cell genomics. Aug 2023
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Nature genetics. Aug 2023
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Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency.
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Nature medicine. Jun 2023
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Nature Human Behaviour. Mar 2023
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Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ, Langenberg C, O'Rahilly S, Ong KK, Perry JRB
Cell genomics. Dec 2022
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Detection and characterization of male sex chromosome abnormalities in the UK Biobank study.
Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Lango Allen H, Day FR, Langenberg C, Frayling TM, Weedon MN, Perry JRB, Ong KK, Murray A
Genetics in medicine : official journal of the American College of Medical Genetics. Jun 2022
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