MRC Epidemiology Unit

 

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.

Watts EL, Gonzales TI, Strain T, Saint-Maurice PF, Bishop DT, Chanock SJ, Johansson M, Keku TO, Le Marchand L, Moreno V, Newcomb PA, Newton CC, Pai RK, Purdue MP, Ulrich CM, Smith-Byrne K, Van Guelpen B, PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS, Day FR, Wijndaele K, Wareham NJ, Matthews CE, Moore SC, Brage S

British journal of cancer. Dec 2023

(DOI : 10.1038/s41416-023-02489-3)

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Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.

Kim Y, Jang H, Wang M, Shi Q, Strain T, Sharp SJ, Yeung SLA, Luo S, Griffin S, Wareham NJ, Wijndaele K, Brage S

Journal of internal medicine. Aug 2023

(DOI : 10.1111/joim.13715)

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Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies.

Garcia L, Pearce M, Abbas A, Mok A, Strain T, Ali S, Crippa A, Dempsey PC, Golubic R, Kelly P, Laird Y, McNamara E, Moore S, de Sá TH, Smith AD, Wijndaele K, Woodcock J, Brage S

British Journal of Sports Medicine. Feb 2023

(DOI : 10.1136/bjsports-2022-105669)

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Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults.

Strain T, Dempsey PC, Wijndaele K, Sharp SJ, Kerrison N, Gonzales TI, Li C, Wheeler E, Langenberg C, Brage S, Wareham N

Diabetes care. Jan 2023

(DOI : 10.2337/dc22-1467)

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Physical Activity Volume, Intensity and Incident Cardiovascular Disease.

Dempsey PC, Rowlands AV, Strain T, Zaccardi F, Dawkins N, Razieh C, Davies MJ, Khunti KK, Edwardson CL, Wijndaele K, Brage S, Yates T

European heart journal. Oct 2022

(DOI : 10.1093/eurheartj/ehac613)

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Association of Accelerometer-Measured Sedentary Accumulation Patterns With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality.

Dempsey PC, Strain T, Winkler EAH, Westgate K, Rennie KL, Wareham NJ, Brage S, Wijndaele K

Journal of the American Heart Association. Apr 2022

(DOI : 10.1161/JAHA.121.023845)

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Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis.

Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R, Kelly P, Khan S, Utukuri M, Laird Y, Mok A, Smith A, Tainio M, Brage S, Woodcock J

JAMA psychiatry. Apr 2022

(DOI : 10.1001/jamapsychiatry.2022.0609)

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Population level physical activity before and during the first national COVID-19 lockdown: A nationally representative repeat cross-sectional study of 5 years of Active Lives data in England.

Strain T, Sharp SJ, Spiers A, Price H, Williams C, Fraser C, Brage S, Wijndaele K, Kelly P

The Lancet regional health. Europe. Dec 2021

(DOI : 10.1016/j.lanepe.2021.100265)

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Physical activity intensity profiles associated with cardiometabolic risk in middle-aged to older men and women.

Dempsey PC, Aadland E, Strain T, Kvalheim OM, Westgate K, Lindsay T, Khaw KT, Wareham NJ, Brage S, Wijndaele K

Preventive medicine. May 2021

(DOI : 10.1016/j.ypmed.2022.106977)

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Joint associations between objectively measured physical activity volume and intensity with body fatness: the Fenland study.

Lindsay T, Wijndaele K, Westgate K, Dempsey P, Strain T, De Lucia Rolfe E, Forouhi NG, Griffin S, Wareham NJ, Brage S

International Journal of Obesity. Mar 2021

(DOI : 10.1038/s41366-021-00970-8)

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Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose-response relationships with disease outcomes.

Gonzales TI, Westgate K, Strain T, Hollidge S, Jeon J, Christensen DL, Jensen J, Wareham NJ, Brage S

Scientific reports. Feb 2021

(DOI : 10.1038/s41598-021-94768-3)

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Is occupational physical activity associated with mortality in UK Biobank?

Pearce M, Strain T, Wijndaele K, Sharp SJ, Mok A, Brage S

The international journal of behavioral nutrition and physical activity. Jan 2021

(DOI : 10.1186/s12966-021-01154-3)

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Levels of domain-specific physical activity at work, in the household, for travel and for leisure among 327 789 adults from 104 countries.

Strain T, Wijndaele K, Garcia L, Cowan M, Guthold R, Brage S, Bull FC

British Journal of Sports Medicine. Sep 2020

(DOI : 10.1136/bjsports-2020-102601)

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Health, environmental and distributional impacts of cycling uptake: The model underlying the Propensity to Cycle tool for England and Wales.

Woodcock J, Aldred R, Lovelace R, Strain T, Goodman A

Journal of transport & health. Aug 2020

(DOI : 10.1016/j.jth.2021.101066)

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Wearable-device-measured physical activity and future health risk.

Strain T, Wijndaele K, Dempsey PC, Sharp SJ, Pearce M, Jeon J, Lindsay T, Wareham N, Brage S

Nature medicine. Dec 2019

(DOI : 10.1038/s41591-020-1012-3)

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Estimating physical activity from self-reported behaviours in large-scale population studies using network harmonisation: findings from UK Biobank and associations with disease outcomes.

Pearce M, Strain T, Kim Y, Sharp SJ, Westgate K, Wijndaele K, Gonzales T, Wareham NJ, Brage S

The international journal of behavioral nutrition and physical activity. Nov 2019

(DOI : 10.1186/s12966-020-00937-4)

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Impact of follow-up time and analytical approaches to account for reverse causality on the association between physical activity and health outcomes in UK Biobank.

Strain T, Wijndaele K, Sharp SJ, Dempsey PC, Wareham N, Brage S

International Journal of Epidemiology. Sep 2019

(DOI : 10.1093/ije/dyz212)

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Use of the prevented fraction for the population to determine deaths averted by existing prevalence of physical activity: a descriptive study.

Strain T, Brage S, Sharp SJ, Richards J, Tainio M, Ding D, Benichou J, Kelly P

The Lancet. Global health. Sep 2019

(DOI : 10.1016/S2214-109X(20)30211-4)

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Specific physical activities, sedentary behaviours and sleep as long-term predictors of accelerometer-measured physical activity in 91,648 adults: a prospective cohort study.

Kim Y, Wijndaele K, Sharp SJ, Strain T, Pearce M, White T, Wareham N, Brage S

The international journal of behavioral nutrition and physical activity. Oct 2018

(DOI : 10.1186/s12966-019-0802-9)

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Physical Activity Surveillance Through Smartphone Apps and Wearable Trackers: Examining the UK Potential for Nationally Representative Sampling.

Strain T, Wijndaele K, Brage S

JMIR mHealth and uHealth. Aug 2018

(DOI : 10.2196/11898)

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A review of global surveillance on the muscle strengthening and balance elements of physical activity recommendations.

Milton K, Varela AR, Strain T, Cavill N, Foster C, Mutrie N

Journal of frailty, sarcopenia and falls. Feb 2018

(DOI : 10.22540/JFSF-03-114)

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Self-rated walking pace and all-cause, cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts.

Stamatakis E, Kelly P, Strain T, Murtagh EM, Ding D, Murphy MH

British Journal of Sports Medicine. Oct 2017

(DOI : 10.1136/bjsports-2017-098677)

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