Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men.
Endocrine Connections 2019
Janus C, Vistisen D, Amadid H, Witte DR, Lauritzen T, Brage S, Bjerregaard AL, Hansen T, Holst JJ, Jørgensen ME, Pedersen O, Færch K, and Torekov S
DOI : 10.1530/EC-19-0408
PubMed ID : 31804964
The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.
Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis.
In 703 men, fasting GLP-1 concentrations were 20% lower (95%CI: -33;-3%, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2% lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1;33%, PrAUC0-30=0.04) and 20% greater at full response (3;40%, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men.
Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.