Comment on "A common genetic variant is associated with adult and childhood obesity".
Science (New York, N.Y.) 2007 ; 315: 187; author reply 187.
DOI : 10.1126/science.1130012
PubMed ID : 17218509
PMCID : PMC2719286
Herbert et al. (Reports, 14 April 2006, p. 279) found that the rs7566605 genetic variant, located upstream of the INSIG2 gene, was consistently associated with increased body mass index. However, we found no evidence of association between rs7566605 and body mass index in two large ethnically homogeneous population-based cohorts. On the contrary, an opposite tendency was observed.